Research

Last updated on 09-08-2016

High Resolution Tissue Respirometry


The High-Resolution Tissue Respirometry (HRTR) Core supports investigators in mitochondrial physiology and pathophysiology studies. The core provides consultation, training, and services for assessment of oxidative phosphorylation in isolated mitochondria, permeabilized cells, or tissue preparations. The HRTR Core uses Oroboros Oxygraph-2k High Resolution Respirometry equipment. Applications of HRTR include: (1) diagnosis of acquired and genetic mitochondrial diseases, myopathies, and neuromuscular pathologies, (2) study of pathologies with reduced cellular respiration, (3) studies on cell function and cell death, (4) aging and senescence, (5) oxidative stress and antioxidant systems, (6) ischemia-reperfusion injury, (7) cancer research / pharmacological tests, (8) environmental stress, and (9) metabolic substrate balance.

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Last modified: 09-08-2016