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Sophie Xiaohui Deng, M.D., Ph.D. [ Edit Your Profile ]

Email Address: deng@jsei.ucla.edu

Work Phone Number: (310) 206-7202

Mailing Address:
100 Stein Plaza
Los Angeles, CA 90095

Work
UCLA Associate Professor, Ophthalmology Associate Professor, Stein Eye Institute Director, Cornea Biology Laboratory

Research Interests

Bioengineering - Tissue Engineering, Medicine - Ophthalmology


Education:
Degrees:
M.D., University of Rochester, School of Medicine and Dentistry
Ph.D., University of Rochester, School of Medicine and Dentistry
Fellowship:
Stein Eye Institute, Department of Ophthalmology, David Geffen School of Medicine at UCLA

Certifications:
Certifications:
2006 American Board of Ophthalmology

About

Dr. Sophie X. Deng is an Associate Professor in the Cornea Division at the Jules Stein Eye Institute, UCLA. Dr. Deng received her doctor of medicine and doctor of philosophy degrees at the University of Rochester School of Medicine and Dentistry, New York, where she completed the rigorous Medical Scientist Training Program. She did her residency in ophthalmology at the Illinois Eye and Ear Infirmary, Chicago. Dr. Deng subsequently completed her fellowship in Cornea, External Ocular Disease and Refractive Surgery at the Jules Stein Eye Institute.

Dr. Deng is a specialist in corneal and external ocular diseases, and cataracts. Her surgical areas include endothelial keratoplasty (DSEK and DMEK), deep anterior lamellar keratoplasty (DALK), penetrating keratoplasty, limbal stem cell transplantation, artificial cornea and cataract.

Dr. Deng is the director of the Cornea Biology Laboratory at the Jules Stein Eye Institute. Her research focuses on corneal epithelial stem cells regulation, deficiency and regeneration. Dr. Deng’s research aims to improve the current treatment for patients with limbal stem cell deficiency by using stem cell therapy to restore vision. In addition, Dr. Deng conducts clinical studies to develop new imaging and molecular tests to accurately diagnose and stage limbal stem cell deficiency.

Publications
Hong Jiaxu, Xu Jianjiang, Wei Anji, Deng Sophie X, Cui Xinhan, Yu Xiaobo, Sun Xinghuai, A new tonometer--the Corvis ST tonometer: clinical comparison with noncontact and Goldmann applanation tonometers. Investigative ophthalmology & visual science. 2013; 54(1): 659-65.
Chen Yinyin, Huang Kevin, Nakatsu Martin N, Xue Zhigang, Deng Sophie X, Fan Guoping, Identification of novel molecular markers through transcriptomic analysis in human fetal and adult corneal endothelial cells. Human molecular genetics. 2013; 22(7): 1271-9.
Kaufman Stephen C, Jacobs Deborah S, Lee W Barry, Deng Sophie X, Rosenblatt Mark I, Shtein Roni M, Options and adjuvants in surgery for pterygium: a report by the American Academy of Ophthalmology. Ophthalmology. 2013; 120(1): 201-8.
Nakatsu Martin N, Vartanyan Lily, Vu Daniel M, Ng Madelena Y, Li Xinmin, Deng Sophie X, Preferential biological processes in the human limbus by differential gene profiling. PloS one. 2013; 8(4): e61833.
Sejpal Kunjal, Bakhtiari Pejman, Deng Sophie X, Presentation, diagnosis and management of limbal stem cell deficiency. Middle East African journal of ophthalmology. 2013; 20(1): 5-10.
Deng Sophie X, Sejpal Kunjal D, Tang Qiongyan, Aldave Anthony J, Lee Olivia L, Yu Fei, Characterization of limbal stem cell deficiency by in vivo laser scanning confocal microscopy: a microstructural approach. Archives of ophthalmology. 2012; 130(4): 440-5.
Hong Jiaxu, Deng Sophie X, Xu Jianjiang, Enzymatic vitreolysis with ocriplasmin for vitreomacular traction and macular holes. The New England journal of medicine. 2012; 367(21): 2053; author reply 2054.
Kurbanyan Kristina, Sejpal Kunjal D, Aldave Anthony J, Deng Sophie X, In vivo confocal microscopic findings in Lisch corneal dystrophy. Cornea. 2012; 31(4): 437-41.
Wang Ling, Deng Sophie X, Lu Luo, Role of CTCF in EGF-induced migration of immortalized human corneal epithelial cells. Investigative ophthalmology & visual science. 2012; 53(2): 946-51.
Hong Jiaxu, Zheng Tianyu, Xu Jianjiang, Deng Sophie X, Chen Ling, Sun Xinghuai, Le Qihua, Li Yimin, Assessment of limbus and central cornea in patients with keratolimbal allograft transplantation using in vivo laser scanning confocal microscopy: an observational study. Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv für klinische und experimentelle Ophthalmologie. 2011; 249(5): 701-8.
Zarei-Ghanavati Siamak, Baghdasaryan Elmira, Ramirez-Miranda Arturo, Nguyen Myhanh, Yu Fei, Lee Grace J, Deng Sophie X, Elevated intraocular pressure is a common complication during active microbial keratitis. American journal of ophthalmology. 2011; 152(4): 575-581.e1.
Ramirez-Miranda Arturo, Nakatsu Martin N, Zarei-Ghanavati Siamak, Nguyen Christine V, Deng Sophie X, Keratin 13 is a more specific marker of conjunctival epithelium than keratin 19. Molecular vision. 2011; 17(5): 1652-61.
Zarei-Ghanavati Siamak, Ramirez-Miranda Arturo, Deng Sophie X, Limbal lacuna: a novel limbal structure detected by in vivo laser scanning confocal microscopy. Ophthalmic surgery, lasers & imaging : the official journal of the International Society for Imaging in the Eye. 2011; 42 Online(2): e129-31.
Tsui Irena, Uslan Daniel Z, Hubschman Jean-Pierre, Deng Sophie X, Nocardia farcinica Infection of a Baerveldt implant and endophthalmitis in a patient with a Boston type I keratoprosthesis. Journal of glaucoma. 2011; 19(5): 339-40.
Wiaux Christophe, Baghdasaryan Elmira, Lee Olivia L, Bourges Jean-Louis, Deng Sophie X, Yu Fei, Aldave Anthony J, Outcomes after Descemet stripping endothelial keratoplasty in glaucoma patients with previous trabeculectomy and tube shunt implantation. Cornea. 2011; 30(12): 1304-11.
Truong Thuy T, Huynh Kyle, Nakatsu Martin N, Deng Sophie X, SSEA4 is a potential negative marker for the enrichment of human corneal epithelial stem/progenitor cells. Investigative ophthalmology & visual science. 2011; 52(9): 6315-20.
Nakatsu Martin N, Ding Zhenhua, Ng Madelena Y, Truong Thuy T, Yu Fei, Deng Sophie X, Wnt/β-catenin signaling regulates proliferation of human cornea epithelial stem/progenitor cells. Investigative ophthalmology & visual science. 2011; 52(7): 4734-41.
Deng Sophie X, Kamal Khairidzan M, Hollander David A, The use of voriconazole in the management of post-penetrating keratoplasty Paecilomyces keratitis. Journal of ocular pharmacology and therapeutics : the official journal of the Association for Ocular Pharmacology and Therapeutics. 2009; 25(2): 175-7.
Asbell Penny A, Colby Kathryn A, Deng Sophie, McDonnell Peter, Meisler David M, Raizman Michael B, Sheppard John D, Sahm Daniel F, Ocular TRUST: nationwide antimicrobial susceptibility patterns in ocular isolates. American journal of ophthalmology. 2008; 145(6): 951-958.
Ding Zhenhua, Dong Jun, Liu Jason, Deng Sophie X, Preferential gene expression in the limbus of the vervet monkey. Molecular vision. 2008; 14(6): 2031-41.
Deng Sophie X, Penland Susan, Gupta Sumit, Fiscella Richard, Edward Deepak P, Tessler Howard H, Goldstein Debra A, Methotrexate reduces the complications of endophthalmitis resulting from intravitreal injection compared with dexamethasone in a rabbit model. Investigative ophthalmology & visual science. 2006; 47(4): 1516-21.