We do not support your browser. Please take a moment and upgrade to the most recent version of Internet Explorer.
CTSI Directory
PROFILE SEARCH:
ADVANCED SEARCH

Steven Piantadosi, M.D., Ph.D. [ Edit Your Profile ]

Email Address: steven.piantadosi@cshs.org
Work Email Address: Steven.Piantadosi@csmc.edu
Work Email Address: steven.piantadosi@cshs.org

Fax Number: 310-423-8300
Work Phone Number: 310-423-3121
310-423-8431

Office Address:
8700 Beverly Blvd.
Suite C-2002
Los Angeles, CA 90095

Work
Cedar-Sinai Medical Center Professor, Department of Medicine Director, Samuel Oschin Cancer Institute
UCLA Professor In-Residence, Biomathematics Professor In-Residence, Medicine

Research Interests

Stats/Methods/Informatics; Stats/Methods/Informatics - Biostatistics and/or Biometry; Medicine; Medicine - Oncology


Education:
Degrees:
M.D., University of North Carolina School of Medicine, 1973 - 1977
Ph.D., University of Alabama, Birmingham, 1978 - 1982
B.A., University of North Carolina, Chapel Hill, 1969 - 1973
Fellowship:
1982 - 1987 National Cancer Institute, Bethesda, MD, Staff Fellow, Biometry Branch
Internship:
1977 - 1978 University of Alabama, Birmingham

About

Steven Piantadosi, MD, PhD is the Phase One Foundation Chair and Director at the Samuel Oschin Comprehensive Cancer Institute at Cedars-Sinai Medical Center. Dr. Piantadosi's role is to lead the Medical Center's programs in cancer research, treatment and education, enhance academic activities related to cancer, and bring together Cedars-Sinai's cancer physicians and researchers for innovative collaborations.

Prior to joining Cedars-Sinai in April 2007, Dr. Piantadosi was professor of oncology at The Johns Hopkins University School of Medicine and Director of Biostatistics at the Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins. He also was professor of biostatistics and professor of epidemiology at the university's Bloomberg School of Public Health. After earning his medical degree from the University of North Carolina and doctorate in Biomathematics from the University of Alabama at Birmingham, Dr. Piantadosi became a senior staff fellow at the National Cancer Institute.

Dr. Piantadosi is one of the world's leading experts in the design and analysis of clinical trials for cancer research. In addition to advising both FDA and industry, he has served on external advisory boards for the National Institutes of Health and other prominent cancer programs and centers.

The author of more than 230 peer-reviewed scientific articles, Dr. Piantadosi currently serves as senior editor of the journal Clinical Cancer Research. He has published extensively on research results, clinical applications, and trial methodology. While his papers have contributed to many diverse areas of oncology, he has also collaborated on studies in disciplines outside cancer including lung disease, AIDS, and degenerative neurological disease.

Dr. Piantadosi is the author of Clinical Trials: A Methodologic Perspective, which is widely considered a classic textbook for clinical trials. He has taught young investigators extensively in his own course in the Hopkins Graduate Training Program in Clinical Investigation, and through international venues such as the AACR/ASCO Workshop on Methods in Clinical Cancer Research. Dr. Piantadosi has held leadership roles with national cooperative oncology groups, including the New Approaches to Brain Tumors Consortium, and as a member of numerous clinical trial monitoring committees.

Publications
Grossman Stuart A, Ye Xiaobu, Piantadosi Steven, Desideri Serena, Nabors Louis B, Rosenfeld Myrna, Fisher Joy, Fisher Joy, Survival of patients with newly diagnosed glioblastoma treated with radiation and temozolomide in research studies in the United States. Clinical cancer research : an official journal of the American Association for Cancer Research. 2010; 16(8): 2443-9.
Azzoli Christopher G, Baker Sherman, Temin Sarah, Pao William, Aliff Timothy, Brahmer Julie, Johnson David H, Laskin Janessa L, Masters Gregory, Milton Daniel, Nordquist Luke, Pfister David G, Piantadosi Steven, Schiller Joan H, Smith Reily, Smith Thomas J, Strawn John R, Trent David, Giaccone Giuseppe, [American Society of Clinical Oncology Clinical Practice Guideline update on chemotherapy for stage IV non-small-cell lung cancer]. Zhongguo fei ai za zhi = Chinese journal of lung cancer. 2010; 13(3): 171-89.
Antonarakis Emmanuel S, Heath Elisabeth I, Walczak Janet R, Nelson William G, Fedor Helen, De Marzo Angelo M, Zahurak Marianna L, Piantadosi Steven, Dannenberg Andrew J, Gurganus Robin T, Baker Sharyn D, Parnes Howard L, DeWeese Theodore L, Partin Alan W, Carducci Michael A, Phase II, randomized, placebo-controlled trial of neoadjuvant celecoxib in men with clinically localized prostate cancer: evaluation of drug-specific biomarkers. Journal of clinical oncology : official journal of the American Society of Clinical Oncology. 2009; 27(30): 4986-93.
Grossman Stuart A, Ye Xiaobu, Chamberlain Marc, Mikkelsen Tom, Batchelor Tracy, Desideri Serena, Piantadosi Steven, Fisher Joy, Fine Howard A, Talampanel with standard radiation and temozolomide in patients with newly diagnosed glioblastoma: a multicenter phase II trial. Journal of clinical oncology : official journal of the American Society of Clinical Oncology. 2009; 27(25): 4155-61.
Emens Leisha A, Asquith Justin M, Leatherman James M, Kobrin Barry J, Petrik Silvia, Laiko Marina, Levi Joy, Daphtary Maithili M, Biedrzycki Barbara, Wolff Antonio C, Stearns Vered, Disis Mary L, Ye Xiaobu, Piantadosi Steven, Fetting John H, Davidson Nancy E, Jaffee Elizabeth M, Timed sequential treatment with cyclophosphamide, doxorubicin, and an allogeneic granulocyte-macrophage colony-stimulating factor-secreting breast tumor vaccine: a chemotherapy dose-ranging factorial study of safety and immune activation. Journal of clinical oncology : official journal of the American Society of Clinical Oncology. 2009; 27(35): 5911-8.
Fine Howard A, Martin Barbara K, Szekely Christine, Brandt Jason, Piantadosi Steven, Breitner John C S, Craft Suzanne, Evans Denis, Green Robert, Mullan Michael, Cognitive function over time in the Alzheimer's Disease Anti-inflammatory Prevention Trial (ADAPT): results of a randomized, controlled trial of naproxen and celecoxib. Archives of neurology. 2008; 65(7): 896-905.
Piantadosi Steven, Rigor in monitoring clinical trials is ethical. Journal of clinical oncology : official journal of the American Society of Clinical Oncology. 2008; 26(4): 683-5.
Kasamon Yvette L, Jones Richard J, Piantadosi Steven, Ambinder Richard F, Abrams Ross A, Borowitz Michael J, Morrison Candis, Smith B Douglas, Flinn Ian W, High-dose therapy and blood or marrow transplantation for non-Hodgkin lymphoma with central nervous system involvement. Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation. 2005; 11(2): 93-100.
Trimble Cornelia L, Piantadosi Steven, Gravitt Patti, Ronnett Brigitte, Pizer Ellen, Elko Andrea, Wilgus Barbara, Yutzy William, Daniel Richard, Shah Keerti, Peng Shiwen, Hung Chienfu, Roden Richard, Wu Tzyy Choou, Pardoll Drew, Spontaneous regression of high-grade cervical dysplasia: effects of human papillomavirus type and HLA phenotype. Clinical cancer research : an official journal of the American Association for Cancer Research. 2005; 11(13): 4717-23.
Piantadosi Steven, Translational clinical trials: an entropy-based approach to sample size. Clinical trials (London, England). 2005; 2(2): 182-92.
Yegnasubramanian Srinivasan, Kowalski Jeanne, Gonzalgo Mark L, Zahurak Marianna, Piantadosi Steven, Walsh Patrick C, Bova G Steven, De Marzo Angelo M, Isaacs William B, Nelson William G, Hypermethylation of CpG islands in primary and metastatic human prostate cancer. Cancer research. 2004; 64(6): 1975-86.
Lee Shing M, Wise Robert, Sternberg Alice L, Tonascia James, Piantadosi Steven, Piantadosi Steven, Methodologic issues in terminating enrollment of a subgroup of patients in a multicenter randomized trial. Clinical trials (London, England). 2004; 1(3): 326-38.
McKenna Robert J, Benditt Joshua O, DeCamp Malcolm, Deschamps Claude, Kaiser Larry, Lee Shing M, Mohsenifar Zab, Piantadosi Steven, Ramsey Scott, Reilly John, Utz James, Utz James, Safety and efficacy of median sternotomy versus video-assisted thoracic surgery for lung volume reduction surgery. The Journal of thoracic and cardiovascular surgery. 2004; 127(5): 1350-60.
North Richard B, Calkins Sherri-Kae, Campbell David S, Sieracki Jeffrey M, Piantadosi Steven, Daly Michael John, Dey P Bobby, Barolat Giancarlo, Automated, patient-interactive, spinal cord stimulator adjustment: a randomized controlled trial. Neurosurgery. 2003; 52(3): 572-80; discussion 579-80.
Brock Malcolm V, Hooker Craig M, Ota-Machida Emi, Han Yu, Guo Mingzhou, Ames Stephen, Glöckner Sabine, Piantadosi Steven, Gabrielson Edward, Pridham Genevieve, Pelosky Kristen, Belinsky Steven A, Yang Stephen C, Baylin Stephen B, Herman James G, DNA methylation markers and early recurrence in stage I lung cancer. The New England journal of medicine. 2008; 358(11): 1118-28.
Han Misop, Partin Alan W, Zahurak Marianna, Piantadosi Steven, Epstein Johnathan I, Walsh Patrick C, Biochemical (prostate specific antigen) recurrence probability following radical prostatectomy for clinically localized prostate cancer. The Journal of urology. 2003; 169(2): 517-23.
Mignano John E, Gage Irene, Piantadosi Steven, Ye Xiaobu, Henderson Gregory, Dooley William C, Local recurrence after mastectomy in patients with T3pN0 breast carcinoma treated without postoperative radiation therapy. American journal of clinical oncology. 2007; 30(5): 466-72.
Piantadosi Steven, Larger lessons from the Women's Health Initiative. Epidemiology (Cambridge, Mass.). 2003; 14(1): 6-7.
Heath Elisabeth I, Canto Marcia Irene, Piantadosi Steven, Montgomery Elizabeth, Weinstein Wilfred M, Herman James G, Dannenberg Andrew J, Yang Vincent W, Shar Albert O, Hawk Ernest, Forastiere Arlene A, Forastiere Arlene A, Secondary chemoprevention of Barrett's esophagus with celecoxib: results of a randomized trial. Journal of the National Cancer Institute. 2007; 99(7): 545-57.
Jacobsohn David A, Chen Allen R, Zahurak Marianna, Piantadosi Steven, Anders Viki, Bolaños-Meade Javier, Higman Meghan, Margolis Jeffrey, Kaup Michele, Vogelsang Georgia B, Phase II study of pentostatin in patients with corticosteroid-refractory chronic graft-versus-host disease. Journal of clinical oncology : official journal of the American Society of Clinical Oncology. 2007; 25(27): 4255-61.
Heath Elisabeth I, DeWeese Theodore L, Partin Alan W, De Marzo Angelo M, Groopman John D, Nelson William G, Piantadosi Steven A, Lieberman Ron, Carducci Michael A, The design of a randomized, placebo-controlled trial of celecoxib in preprostatectomy men with clinically localized adenocarcinoma of the prostate. Clinical prostate cancer. 2002; 1(3): 182-7.
Piantadosi Steven, Improving the quality of clinical trials in surgery. The Journal of thoracic and cardiovascular surgery. 2006; 132(2): 247-8.
Gorin Norbert-Claude, Piantadosi Steven, Stull Margaret, Bonte Helene, Wingard John R, Civin Curt, Increased risk of lethal graft-versus-host disease-like syndrome after transplantation into NOD/SCID mice of human mobilized peripheral blood stem cells, as compared to bone marrow or cord blood. Journal of hematotherapy & stem cell research. 2002; 11(2): 277-92.
Giardiello Francis M, Yang Vincent W, Hylind Linda M, Krush Anne J, Petersen Gloria M, Trimbath Jill D, Piantadosi Steven, Garrett Elizabeth, Geiman Deborah E, Hubbard Walter, Offerhaus G Johan A, Hamilton Stanley R, Primary chemoprevention of familial adenomatous polyposis with sulindac. The New England journal of medicine. 2002; 346(14): 1054-9.
Simons Jonathan W, Carducci Michael A, Mikhak Bahar, Lim Michael, Biedrzycki Barbara, Borellini Flavia, Clift Shirley M, Hege Kristen M, Ando Dale G, Piantadosi Steven, Mulligan Richard, Nelson William G, Phase I/II trial of an allogeneic cellular immunotherapy in hormone-naïve prostate cancer. Clinical cancer research : an official journal of the American Association for Cancer Research. 2006; 12(11 Pt 1): 3394-401.
Heath Elisabeth I, Urba Susan, Marshall John, Piantadosi Steven, Forastiere Arlene A, Phase II trial of docetaxel chemotherapy in patients with incurable adenocarcinoma of the esophagus. Investigational new drugs. 2002; 20(1): 95-9.
Gore Steven D, Smith B Douglas, Gojo Ivana, Grever Michael, Kaufmann Scott H, Letendre Louis, Leonard Debra G B, Marcucci Guido, Miller Carole B, Morris Lawrence, Piantadosi Steven, Prior Thomas, Stock Wendy, Karp Judith E, Durable molecular remissions with a single cycle of timed sequential consolidation chemotherapy in acute promyelocytic leukemia. American journal of hematology. 2005; 79(2): 119-27.
Hu Rong, Mukhina Galina L, Piantadosi Steven, Barber Jamie P, Jones Richard J, Brodsky Robert A, PIG-A mutations in normal hematopoiesis. Blood. 2005; 105(10): 3848-54.
Wang Haibin, Yatawara Mahendra, Huang Shao-Chi, Dudley Kevin, Szekely Christine, Holden Stuart, Piantadosi Steven, The integrated proactive surveillance system for prostate cancer. The open medical informatics journal. 2012; 6(3): 1-8.
Hansel Donna E, Maitra Anirban, Lin John W, Goggins Michael, Argani Pedram, Yeo Charles J, Piantadosi Steven, Leach Steven D, Biankin Andrew V, Expression of the caudal-type homeodomain transcription factors CDX 1/2 and outcome in carcinomas of the ampulla of Vater. Journal of clinical oncology : official journal of the American Society of Clinical Oncology. 2005; 23(9): 1811-8.
North Richard B, Kidd David H, Farrokhi Farrokh, Piantadosi Steven A, Spinal cord stimulation versus repeated lumbosacral spine surgery for chronic pain: a randomized, controlled trial. Neurosurgery. 2005; 56(1): 98-106; discussion 106-7.
Rudek Michelle A, New Pamela, Mikkelsen Tom, Phuphanich Surasak, Alavi Jane B, Nabors Louis B, Piantadosi Steven, Fisher Joy D, Grossman Stuart A, Phase I and pharmacokinetic study of COL-3 in patients with recurrent high-grade gliomas. Journal of neuro-oncology. 2011; 105(2): 375-81.
Azzoli Christopher G, Temin Sarah, Aliff Timothy, Baker Sherman, Brahmer Julie, Johnson David H, Laskin Janessa L, Masters Gregory, Milton Daniel, Nordquist Luke, Pao William, Pfister David G, Piantadosi Steven, Schiller Joan H, Smith Reily, Smith Thomas J, Strawn John R, Trent David, Giaccone Giuseppe, Giaccone Giuseppe, 2011 Focused Update of 2009 American Society of Clinical Oncology Clinical Practice Guideline Update on Chemotherapy for Stage IV Non-Small-Cell Lung Cancer. Journal of clinical oncology : official journal of the American Society of Clinical Oncology. 2011; 29(28): 3825-31.
Orlowski Robert Z, Mills Sharon R, Hartley Eric E, Ye Xiaobu, Piantadosi Steven, Ambinder Richard F, Gore Steven D, Miller Carole B, Oral valacyclovir as prophylaxis against herpes simplex virus reactivation during high dose chemotherapy for leukemia. Leukemia & lymphoma. 2004; 45(11): 2215-9.
Grossman Stuart A, Ye Xiaobu, Lesser Glenn, Sloan Andrew, Carraway Hetty, Desideri Serena, Piantadosi Steven, Piantadosi Steven, Immunosuppression in patients with high-grade gliomas treated with radiation and temozolomide. Clinical cancer research : an official journal of the American Association for Cancer Research. 2011; 17(16): 5473-80.
North Richard B, Brigham David D, Khalessi Alexander, Calkins Sherri-Kae, Piantadosi Steven, Campbell David S, Daly Michael John, Dey P Bobby, Barolat Giancarlo, Taylor Rod, Spinal Cord Stimulator Adjustment to Maximize Implanted Battery Longevity: A Randomized, Controlled Trial Using a Computerized, Patient-Interactive Programmer. Neuromodulation : journal of the International Neuromodulation Society. 2004; 7(1): 13-25.
Canto Marcia Irene, Goggins Michael, Yeo Charles J, Griffin Constance, Axilbund Jennifer E, Brune Kieran, Ali Syed Z, Jagannath Sanjay, Petersen Gloria M, Fishman Elliot K, Piantadosi Steven, Giardiello Francis M, Hruban Ralph H, Screening for pancreatic neoplasia in high-risk individuals: an EUS-based approach. Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association. 2004; 2(7): 606-21.
Akpek Gorgun, Lee Stephanie J, Flowers Mary E, Pavletic Steven Z, Arora Mukta, Lee Shing, Piantadosi Steven, Guthrie Katherine A, Lynch James C, Takatu Alessandra, Horowitz Mary M, Antin Joseph H, Weisdorf Daniel J, Martin Paul J, Vogelsang Georgia B, Performance of a new clinical grading system for chronic graft-versus-host disease: a multicenter study. Blood. 2003; 102(3): 802-9.
Lutz Eric, Yeo Charles J, Lillemoe Keith D, Biedrzycki Barbara, Kobrin Barry, Herman Joseph, Sugar Elizabeth, Piantadosi Steven, Cameron John L, Solt Sara, Onners Beth, Tartakovsky Irena, Choi Miri, Sharma Rajni, Illei Peter B, Hruban Ralph H, Abrams Ross A, Le Dung, Jaffee Elizabeth, Laheru Dan, A lethally irradiated allogeneic granulocyte-macrophage colony stimulating factor-secreting tumor vaccine for pancreatic adenocarcinoma. A Phase II trial of safety, efficacy, and immune activation. Annals of surgery. 2011; 253(2): 328-35.
Gilbert Mark R, Supko Jeffrey G, Batchelor Tracy, Lesser Glenn, Fisher Joy D, Piantadosi Steven, Grossman Stuart, Phase I clinical and pharmacokinetic study of irinotecan in adults with recurrent malignant glioma. Clinical cancer research : an official journal of the American Association for Cancer Research. 2003; 9(8): 2940-9.
Smith B Douglas, Jones Richard J, Cho Eunpi, Kowalski Jeanne, Karp Judith E, Gore Steven D, Vala Milada, Meade Brooke, Baker Sharyn D, Zhao Ming, Piantadosi Steven, Zhang Zhe, Blumenthal Gideon, Warlick Erica D, Brodsky Robert A, Murgo Anthony, Rudek Michelle A, Matsui William H, Differentiation therapy in poor risk myeloid malignancies: Results of a dose finding study of the combination bryostatin-1 and GM-CSF. Leukemia research. 2011; 35(1): 87-94.
Su Shu-Chih, Kanarek Norma, Fox Michael G, Guseynova Alla, Crow Shirley, Piantadosi Steven, Spatial analyses identify the geographic source of patients at a National Cancer Institute Comprehensive Cancer Center. Clinical cancer research : an official journal of the American Association for Cancer Research. 2010; 16(3): 1065-72.
Fishman Alfred, Martinez Fernando, Naunheim Keith, Piantadosi Steven, Wise Robert, Ries Andrew, Weinmann Gail, Wood Douglas E, Wood Douglas E, A randomized trial comparing lung-volume-reduction surgery with medical therapy for severe emphysema. The New England journal of medicine. 2003; 348(21): 2059-73.
Azzoli Christopher G, Baker Sherman, Temin Sarah, Pao William, Aliff Timothy, Brahmer Julie, Johnson David H, Laskin Janessa L, Masters Gregory, Milton Daniel, Nordquist Luke, Pfister David G, Piantadosi Steven, Schiller Joan H, Smith Reily, Smith Thomas J, Strawn John R, Trent David, Giaccone Giuseppe, Giaccone Giuseppe, American Society of Clinical Oncology Clinical Practice Guideline update on chemotherapy for stage IV non-small-cell lung cancer. Journal of clinical oncology : official journal of the American Society of Clinical Oncology. 2009; 27(36): 6251-66.