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Olujimi A Ajijola, M.D., Ph.D. [ Edit Your Profile ]

Email Address: oajijola@mednet.ucla.edu

Work
UCLA Assistant Professor In-Residence, UCLA Cardiac Arrhythmia Center

Education:
Degrees:
M.D.
Ph.D.

About

From a clinical research perspective, I am interested in the application of neuro-modulatory therapies, as adjunctive therapies, for treating patients with minor and severe cardiac arrhythmias. My basic/translational research interests are focused on understanding how cardiac sympathetic innervation remodels in response to ischemic or non-ischemic cardiac injury, and the mechanistic underpinnings of myocardial arrhythmogenesis in this setting. Using state-of-the-art electrical mapping techniques, we are able to study myocardial electrical propagation under a variety of sympathetic and parasympathetic loads. In addition to cardiac electrical mapping, other expertise includes intraganglionic neural recordings, targeted inductions of myocardial infarctions in animal models.

Publications
Ajijola Olujimi A, Howard-Quijano Kimberly, Scovotti Jennifer, Vaseghi Marmar, Lee Christine, Mahajan Aman, Shivkumar Kalyanam, Augmentation of cardiac sympathetic tone by percutaneous low-level stellate ganglion stimulation in humans: a feasibility study. Physiological reports. 2015; 3(3): .
Ajijola Olujimi A, Yagishita Daigo, Reddy Naveen K, Yamakawa Kentaro, Vaseghi Marmar, Downs Anthony M, Hoover Donald B, Ardell Jeffrey L, Shivkumar Kalyanam, Remodeling of Stellate Ganglion Neurons following Spatially Targeted Myocardial Infarction: Neuropeptide And Morphologic Changes. Heart rhythm : the official journal of the Heart Rhythm Society. 2015; .
Ajijola Olujimi A, Tung Roderick, Shivkumar Kalyanam, Ventricular tachycardia in ischemic heart disease substrates. Indian heart journal. 2014; 66S1(3): S24-S34.
Irie Tadanobu, Yu Ricky, Bradfield Jason S, Vaseghi Marmar, Buch Eric F, Ajijola Olujimi, Macias Carlos, Fujimura Osamu, Mandapati Ravi, Boyle Noel G, Shivkumar Kalyanam, Tung Roderick, Relationship Between Sinus Rhythm Late Activation Zones and Critical Sites for Scar-Related Ventricular Tachycardia: A Systematic Analysis of Isochronal Late Activation Mapping. Circulation. Arrhythmia and electrophysiology. 2015; .
Vaseghi Marmar, Gima Jean, Kanaan Christopher, Ajijola Olujimi A, Marmureanu Alexander, Mahajan Aman, Shivkumar Kalyanam, Cardiac sympathetic denervation in patients with refractory ventricular arrhythmias or electrical storm: intermediate and long-term follow-up. Heart rhythm : the official journal of the Heart Rhythm Society. 2014; 11(3): 360-6.
Truong Quynh A, Januzzi James L, Szymonifka Jackie, Thai Wai-Ee, Wai Bryan, Lavender Zachary, Sharma Umesh, Sandoval Ryan M, Grunau Zachary S, Basnet Sandeep, Babatunde Adefolakemi, Ajijola Olujimi A, Min James K, Singh Jagmeet P, Coronary sinus biomarker sampling compared to peripheral venous blood for predicting outcomes in patients with severe heart failure undergoing cardiac resynchronization therapy: The BIOCRT study. Heart rhythm : the official journal of the Heart Rhythm Society. 2014; 11(12): 2167-75.
Krishnamoorthi Shankarjee, Perotti Luigi E, Borgstrom Nils P, Ajijola Olujimi A, Frid Anna, Ponnaluri Aditya V, Weiss James N, Qu Zhilin, Klug William S, Ennis Daniel B, Garfinkel Alan, Simulation Methods and Validation Criteria for Modeling Cardiac Ventricular Electrophysiology. PloS one. 2014; 9(12): e114494.
Yagishita Daigo, Chui Ray W, Yamakawa Kentaro, Rajendran Pradeep S, Ajijola Olujimi A, Nakamura Keijiro, So Eileen L, Mahajan Aman, Shivkumar Kalyanam, Vaseghi Marmar, Sympathetic Nerve Stimulation, Not Circulating Norepinephrine, Modulates T-Peak to T-End Interval by Increasing Global Dispersion of Repolarization. Circulation. Arrhythmia and electrophysiology. 2014; .
Khalsa Sahib S, Shahabi Leila, Ajijola Olujimi A, Bystritsky Alexander, Naliboff Bruce D, Shivkumar Kalyanam, Synergistic application of cardiac sympathetic decentralization and comprehensive psychiatric treatment in the management of anxiety and electrical storm. Frontiers in integrative neuroscience. 2014; 7(12): 98.
Zhou Wei, Yamakawa Kentaro, Benharash Peyman, Ajijola Olujimi, Ennis Daniel, Hadaya Joseph, Vaseghi Marmar, Shivkumar Kalyanam, Mahajan Aman, Effect of stellate ganglia stimulation on global and regional left ventricular function as assessed by speckle tracking echocardiography. American journal of physiology. Heart and circulatory physiology. 2013; 304(6): H840-7.
Yagishita Daigo, Ajijola Olujimi A, Vaseghi Marmar, Nsair Ali, Zhou Wei, Yamakawa Kentaro, Tung Roderick, Mahajan Aman, Shivkumar Kalyanam, Electrical homogenization of ventricular scar by application of collagenase: a novel strategy for arrhythmia therapy. Circulation. Arrhythmia and electrophysiology. 2013; 6(4): 776-83.
Ajijola Olujimi A, Yagishita Daigo, Patel Krishan J, Vaseghi Marmar, Zhou Wei, Yamakawa Kentaro, So Eileen, Lux Robert L, Mahajan Aman, Shivkumar Kalyanam, Focal myocardial infarction induces global remodeling of cardiac sympathetic innervation: neural remodeling in a spatial context. American journal of physiology. Heart and circulatory physiology. 2013; 305(7): H1031-40.
Ajijola Olujimi A, Vaseghi Marmar, Zhou Wei, Yamakawa Kentaro, Benharash Peyman, Hadaya Joseph, Lux Robert L, Mahajan Aman, Shivkumar Kalyanam, Functional differences between junctional and extrajunctional adrenergic receptor activation in mammalian ventricle. American journal of physiology. Heart and circulatory physiology. 2013; 304(4): H579-88.
Vaseghi Marmar, Yamakawa Kentaro, Sinha Arjun, So Eileen L, Zhou Wei, Ajijola Olujimi A, Lux Robert L, Laks Michael, Shivkumar Kalyanam, Mahajan Aman, Modulation of regional dispersion of repolarization and T-peak to T-end interval by the right and left stellate ganglia. American journal of physiology. Heart and circulatory physiology. 2013; 305(7): H1020-30.
Ajijola Olujimi A, Sun Albert Y, The genetics of the J wave patterns. Journal of electrocardiology. 2013; 46(5): 395-8.
Ramirez Rafael J, Ajijola Olujimi A, Zhou Wei, Holmström Björn, Lüning Hampus, Laks Michael M, Shivkumar Kalyanam, Mahajan Aman, A new electrocardiographic marker for sympathetic nerve stimulation: modulation of repolarization by stimulation of stellate ganglia. Journal of electrocardiology. 2012; 44(6): 694-9.
Ajijola Olujimi A, Lellouche Nicholas, Bourke Tara, Tung Roderick, Ahn Samuel, Mahajan Aman, Shivkumar Kalyanam, Bilateral cardiac sympathetic denervation for the management of electrical storm. Journal of the American College of Cardiology. 2012; 59(1): 91-2.
Ajijola Olujimi A, Vaseghi Marmar, Mahajan Aman, Shivkumar Kalyanam, Bilateral cardiac sympathetic denervation: why, who and when?. Expert review of cardiovascular therapy. 2012; 10(8): 947-9.
Zhou Wei, Ko Yoshihiro, Benharash Peyman, Yamakawa Kentaro, Patel Sunny, Ajijola Olujimi A, Mahajan Aman, Cardioprotection of electroacupuncture against myocardial ischemia-reperfusion injury by modulation of cardiac norepinephrine release. American journal of physiology. Heart and circulatory physiology. 2012; 302(9): H1818-25.
Ajijola Olujimi A, Wisco Jonathan J, Lambert H Wayne, Mahajan Aman, Stark Elena, Fishbein Michael C, Shivkumar Kalyanam, Extracardiac neural remodeling in humans with cardiomyopathy. Circulation. Arrhythmia and electrophysiology. 2012; 5(5): 1010-116.
Ajijola Olujimi A, Shivkumar Kalyanam, Neural remodeling and myocardial infarction: the stellate ganglion as a double agent. Journal of the American College of Cardiology. 2012; 59(10): 962-4.
Shaw Stanley Y, Cheng Susan, Cupples L Adrienne, Larson Martin G, McCabe Elizabeth L, Ngwa Julius S, Wang Ying A, Martin Roderick P, Klein Rachael J, Hashmi Basma, Ajijola Olujimi A, Lau Evan, O'Donnell Christopher J, Vasan Ramachandran S, Cohen Kenneth S, Wang Thomas J, Genetic and clinical correlates of early-outgrowth colony-forming units. Circulation. Cardiovascular genetics. 2011; 4(3): 296-304.
Ajijola Olujimi A, Macklin Eric A, Moore Stephanie A, McCarty David, Bischoff Kara E, Heist Edwin Kevin, Picard Michael, Ruskin Jeremy N, Dec George William, Singh Jagmeet P, Inpatient vs. elective outpatient cardiac resynchronization therapy device implantation and long-term clinical outcome. Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology. 2010; 12(12): 1745-9.
Ajijola Olujimi A, Dong Chunming, Herderick Edward E, Ma Qi, Goldschmidt-Clermont Pascal J, Yan Zhen, Voluntary running suppresses proinflammatory cytokines and bone marrow endothelial progenitor cell levels in apolipoprotein-E-deficient mice. Antioxidants & redox signaling. 2009; 11(1): 15-23.
Ajijola Olujimi A, Nandigam K Veena, Chabner Bruce A, Orencole Mary, Dec G William, Ruskin Jeremy N, Singh Jagmeet P, Usefulness of cardiac resynchronization therapy in the management of Doxorubicin-induced cardiomyopathy. The American journal of cardiology. 2008; 101(9): 1371-2.
Ajijola Olujimi A, Goldschmidt-Clermont Pascal J, Satterwhite Lisa L, CD40 ligand: not bad to the bone (marrow), after all. Arteriosclerosis, thrombosis, and vascular biology. 2005; 25(6): 1088-90.
Ajijola Olujimi A, Boyle Noel G, Shivkumar Kalyanam, Detecting and monitoring arrhythmia recurrence following catheter ablation of atrial fibrillation. Frontiers in physiology. 2015; 6: 90.
Ajijola Olujimi A, Sudden cardiac death: We are not there yet. Trends in cardiovascular medicine. 2015; .
Rajendran Pradeep S, Nakamura Keijiro, Ajijola Olujimi A, Vaseghi Marmar, Armour J Andrew, Ardell Jeffrey L, Shivkumar Kalyanam, Myocardial infarction induces structural and functional remodelling of the intrinsic cardiac nervous system. The Journal of physiology. 2016; 594(2): 321-41.
Yamakawa Kentaro, Howard-Quijano Kimberly, Zhou Wei, Rajendran Pradeep S, Yagishita Daigo, Vaseghi Marmar, Ajijola Olujimi A, Armour J Andrew, Shivkumar Kalyanam, Ardell Jeffrey Laurence, Mahajan Aman, Central vs peripheral neuraxial sympathetic control of porcine ventricular electrophysiology. American journal of physiology. Regulatory, integrative and comparative physiology. 2015; 594(2): ajpregu.00252.2015.
Shivkumar Kalyanam, Ajijola Olujimi A, Anand Inder, Armour J Andrew, Chen Peng-Sheng, Esler Murray, De Ferrari Gaetano, Fishbein Michael C, Goldberger Jeffrey J, Harper Ronald M, Joyner Michael J, Khalsa Sahib S, Kumar Rajesh, Lane Richard, Mahajan Aman, Po Sunny, Schwartz Peter J, Somers Virend K, Valderrabano Miguel, Vaseghi Marmar, Zipes Douglas P, Clinical neurocardiology-defining the value of neuroscience-based cardiovascular therapeutics. The Journal of physiology. 2016; .
Mukku Roy B, Fonarow Gregg C, Watson Karol E, Ajijola Olujimi A, Depasquale Eugene C, Nsair Ali, Baas Arnold S, Deng Mario C, Yang Eric H, Heart Failure Therapies for End Stage Chemotherapy Induced Cardiomyopathy. Journal of cardiac failure. 2016; .
Te Riele Anneline S J M, Ajijola Olujimi A, Shivkumar Kalyanam, Tandri Harikrishna, Role of Bilateral Sympathectomy in the Treatment of Refractory Ventricular Arrhythmias in Arrhythmogenic Right Ventricular Dysplasia/Cardiomyopathy. Circulation. Arrhythmia and electrophysiology. 2016; 9(4): .
Nakamura Keijiro, Ajijola Olujimi A, Aliotta Eric, Armour J Andrew, Ardell Jeffrey L, Shivkumar Kalyanam, Pathological effects of chronic myocardial infarction on peripheral neurons mediating cardiac neurotransmission. Autonomic neuroscience : basic & clinical. 2016; 197: 34-40.
Ajijola Olujimi A, Hamon David, NON-INVASIVE NEUROMODULATION VIA TRAGAL STIMULATION: TIME TO LEND AN EAR?. JACC. Clinical electrophysiology. 2016; 2(3): 340-342.
Teng Alexandra E, Massoud Louis, Ajijola Olujimi A, Physiological mechanisms of QRS narrowing in bundle branch block patients undergoing permanent His bundle pacing. Journal of electrocardiology. 2016; 49(5): 644-8.
Ajijola Olujimi A, Shivkumar Kalyanam, Habecker Beth A, Natriuretic peptides and peripheral autonomic neurotransmission: back to the A, B, and C's. Cardiovascular research. 2016; 112(3): 619-621.
Ajijola Olujimi A, Romero Jorge, Vorobiof Gabriel, Suh William M, Shivkumar Kalyanam, Tung Roderick, Hyper-response to cardiac resynchronization with permanent His bundle pacing: Is parahisian pacing sufficient?. HeartRhythm case reports. 2015; 1(6): 429-433.
Tung Roderick, Kim Steve, Yagishita Daigo, Vaseghi Marmar, Ennis Daniel B, Ouadah Sarah, Ajijola Olujimi A, Bradfield Jason S, Mahapatra Srijoy, Finn Paul, Shivkumar Kalyanam, Scar voltage threshold determination using ex vivo magnetic resonance imaging integration in a porcine infarct model: Influence of interelectrode distances and three-dimensional spatial effects of scar. Heart rhythm. 2016; 13(10): 1993-2002.
Teng Alexandra E, Lustgarten Daniel L, Vijayaraman Pugazhendhi, Tung Roderick, Shivkumar Kalyanam, Wagner Galen S, Ajijola Olujimi A, Usefulness of His Bundle Pacing to Achieve Electrical Resynchronization in Patients With Complete Left Bundle Branch Block and the Relation Between Native QRS Axis, Duration, and Normalization. The American journal of cardiology. 2016; 118(4): 527-34.
Romero Jorge, Ajijola Olujimi A, Boyle Noel, Shivkumar Kalyanam, Tung Roderick, Prolonged high-power endocardial ablation of epicardial microreentrant VT from the LV summit in a patient with nonischemic cardiomyopathy. HeartRhythm case reports. 2015; 1(6): 464-468.
Ajijola Olujimi A, Upadhyay Gaurav, Macias Carlos, Shivkumar Kalyanam, Tung Roderick, Permanent His Bundle Pacing for Cardiac Resychronization Therapy: Initial Feasibility Study in Lieu of Left Ventricular Lead. Heart rhythm. 2017; .
Hamon David, Rajendran Pradeep S, Chui Ray W, Ajijola Olujimi A, Irie Tadanobu, Talebi Ramin, Salavatian Siamak, Vaseghi Marmar, Bradfield Jason S, Armour J Andrew, Ardell Jeffrey L, Shivkumar Kalyanam, Premature Ventricular Contraction Coupling Interval Variability Destabilizes Cardiac Neuronal and Electrophysiological Control: Insights From Simultaneous Cardioneural Mapping. Circulation. Arrhythmia and electrophysiology. 2017; 10(4): .
Ajijola Olujimi A, Lux Robert L, Khahera Anadjeet, Kwon OhJin, Aliotta Eric, Ennis Daniel B, Fishbein Michael C, Ardell Jeffrey L, Shivkumar Kalyanam, Sympathetic modulation of electrical activation in normal and infarcted myocardium: implications for arrhythmogenesis. American journal of physiology. Heart and circulatory physiology. 2017; 312(3): H608-H621.