We do not support your browser. Please take a moment and upgrade to the most recent version of Internet Explorer.
CTSI Directory
PROFILE SEARCH:
ADVANCED SEARCH

Mourad Tighiouart, Ph.D. [ Edit Your Profile ]

Work
Cedar-Sinai Medical Center Assistant Director, Biostatistics and Bioinformatics Associate Professor, Department of Medicine

Education:
Degrees:
Ph.D., Florida State University, Tallahassee, FL
M.S., University of Central Florida, Orlando, FL
M.S., Florida State University, Tallahassee, FL
B.S., University of Science & Technology, Algiers

About

Dr. Tighiourat contributed to the CTSI as a Co-Investigator in the Biostatistics, Study Design and Clinical Data Management Program during the past funding period in three areas: collaborative research, methodological research and education. His collaborative research consists of working closely with clinical and basic science researchers to design efficient and safe clinical trials and animal experiments. In particular, he collaborates with many scientists on a regular basis in designing and analyzing experiments and studies. He has extensive experience analyzing biomarker expression and alterations in both human cancer tissue and blood specimens and animal studies. In particular, Dr. Tighiourat participated in many data analyses exploring correlations of key biomarkers in human tissue specimens with clinical characteristics such as tumor stage, disease free survival, and overall survival and correlation of these markers using demographic variables using univariate and multivariable analyses. His current methodological research is developing safe and efficient phase I/II cancer clinical trials of dose combinations of cytotoxic and biologic agents. He is the PI of a research project funded by NCI to develop Bayesian adaptive designs exploring treatments efficacy and safety by combining several agents. Regarding education,he lectured in the Statistics in Medical Research Fall ten-lecture series that has been attended by an average of 230 faculty and students each year.

Publications
Kali Avinash, Choi Eui-Young, Sharif Behzad, Kim Young Jin, Bi Xiaoming, Spottiswoode Bruce, Cokic Ivan, Yang Hsin-Jung, Tighiouart Mourad, Conte Antonio Hernandez, Li Debiao, Berman Daniel S, Choi Byoung Wook, Chang Hyuk-Jae, Dharmakumar Rohan, Native T1 Mapping by 3-T CMR Imaging for Characterization of Chronic Myocardial Infarctions. JACC. Cardiovascular imaging. 2015; 8(9): 1019-30.
Cokic Ivan, Kali Avinash, Yang Hsin-Jung, Yee Raymond, Tang Richard, Tighiouart Mourad, Wang Xunzhang, Jackman Warren S, Chugh Sumeet S, White James A, Dharmakumar Rohan, Iron-Sensitive Cardiac Magnetic Resonance Imaging for Prediction of Ventricular Arrhythmia Risk in Patients With Chronic Myocardial Infarction: Early Evidence. Circulation. Cardiovascular imaging. 2015; 8(8): .
Owonikoko Taofeek K, Ramalingam Suresh S, Miller Daniel L, Force Seth D, Sica Gabriel L, Mendel Jennifer, Chen Zhengjia, Rogatko Andre, Tighiouart Mourad, Harvey R Donald, Kim Sungjin, Saba Nabil F, Pickens Allan, Behera Madhusmita, Fu Robert W, Rossi Michael R, Auffermann William F, Torres William E, Bechara Rabih, Deng Xingming, Sun Shi-Yong, Fu Haian, Gal Anthony A, Khuri Fadlo R, A Translational, Pharmacodynamic, and Pharmacokinetic Phase IB Clinical Study of Everolimus in Resectable Non-Small Cell Lung Cancer. Clinical cancer research : an official journal of the American Association for Cancer Research. 2015; 21(8): 1859-68.
Zhang Xiao, Li Quanlin, Rogatko Andre, Tighiouart Mourad, Hardison Regina M, Brooks Maria Mori, Kelsey Sheryl F, Kaul Sanjay, Bairey Merz C Noel, Analysis of the bypass angioplasty revascularization investigation trial using a multistate model of clinical outcomes. The American journal of cardiology. 2015; 115(8): 1073-9.
Shah Rashmee U, Henry Timothy D, Rutten-Ramos Stephanie, Garberich Ross F, Tighiouart Mourad, Bairey Merz C Noel, Increasing percutaneous coronary interventions for ST-segment elevation myocardial infarction in the United States: progress and opportunity. JACC. Cardiovascular interventions. 2015; 8(1 Pt B): 139-46.
Nelson Michael D, Szczepaniak Lidia S, LaBounty Troy M, Szczepaniak Edward, Li Debiao, Tighiouart Mourad, Li Quanlin, Dharmakumar Rohan, Sannes Gregg, Fan Zhaoyang, Yumul Roya, Hardy W David, Hernandez Conte Antonio, Cardiac steatosis and left ventricular dysfunction in HIV-infected patients treated with highly active antiretroviral therapy. JACC. Cardiovascular imaging. 2014; 7(11): 1175-7.
Tighiouart Mourad, Piantadosi Steven, Rogatko André, Dose finding with drug combinations in cancer phase I clinical trials using conditional escalation with overdose control. Statistics in medicine. 2014; 33(22): 3815-29.
Cheon Dong-Joo, Tong Yunguang, Sim Myung-Shin, Dering Judy, Berel Dror, Cui Xiaojiang, Lester Jenny, Beach Jessica A, Tighiouart Mourad, Walts Ann E, Karlan Beth Y, Orsulic Sandra, A collagen-remodeling gene signature regulated by TGF-β signaling is associated with metastasis and poor survival in serous ovarian cancer. Clinical cancer research : an official journal of the American Association for Cancer Research. 2014; 20(3): 711-23.
Shao Chen, Liao Chun-Peng, Hu Peizhen, Chu Chia-Yi, Zhang Lei, Bui Matthew H T, Ng Christopher S, Josephson David Y, Knudsen Beatrice, Tighiouart Mourad, Kim Hyung L, Zhau Haiyen E, Chung Leland W K, Wang Ruoxiang, Posadas Edwin M, Detection of live circulating tumor cells by a class of near-infrared heptamethine carbocyanine dyes in patients with localized and metastatic prostate cancer. PloS one. 2014; 9(2): e88967.
Tighiouart Mourad, Liu Yuan, Rogatko André, Escalation with overdose control using time to toxicity for cancer phase I clinical trials. PloS one. 2014; 9(3): e93070.
Fan Songqing, Müller Susan, Chen Zhuo Georgia, Pan Lin, Tighiouart Mourad, Shin Dong M, Khuri Fadlo R, Sun Shi-Yong, Prognostic impact of Fas-associated death domain, a key component in death receptor signaling, is dependent on the presence of lymph node metastasis in head and neck squamous cell carcinoma. Cancer biology & therapy. 2013; 14(4): 365-9.
Wang Haibin, Tighiouart Mourad, Huang Shao-Chi, Berel Dror, Cook-Wiens Galen, Bresee Catherine, Li Quanlin, Rogatko André, The Integrated Web Portal for Escalation with Overdose Control (EWOC). The open medical informatics journal. 2013; 7(2): 18-23.
Arellano Martha, Pakkala Suchita, Langston Amelia, Tighiouart Mourad, Pan Lin, Chen Zhengjia, Heffner Leonard T, Lonial Sagar, Winton Elliott, Khoury H Jean, Early clearance of peripheral blood blasts predicts response to induction chemotherapy in acute myeloid leukemia. Cancer. 2012; 118(21): 5278-82.
Song Shlee S, Latour Lawrence L, Ritter Carsten H, Wu Ona, Tighiouart Mourad, Hernandez Daymara A, Ku Katherine D, Luby Marie, Warach Steven, A pragmatic approach using magnetic resonance imaging to treat ischemic strokes of unknown onset time in a thrombolytic trial. Stroke; a journal of cerebral circulation. 2012; 43(9): 2331-5.
Chen Zhengjia, Tighiouart Mourad, Kowalski Jeanne, Dose escalation with overdose control using a quasi-continuous toxicity score in cancer Phase I clinical trials. Contemporary clinical trials. 2012; 33(5): 949-58.
Wang Dongsheng, Müller Susan, Amin A R M Ruhul, Huang Donghai, Su Ling, Hu Zhongliang, Rahman Mohammad Aminur, Nannapaneni Sreenivas, Koenig Lydia, Chen Zhengjia, Tighiouart Mourad, Shin Dong M, Chen Zhuo G, The pivotal role of integrin β1 in metastasis of head and neck squamous cell carcinoma. Clinical cancer research : an official journal of the American Association for Cancer Research. 2012; 18(17): 4589-99.
Zhang Hongzheng, Yun Sujin, Batuwangala Thil D, Steward Michael, Holmes Steve D, Pan Lin, Tighiouart Mourad, Shin Hyung Ju C, Koenig Lydia, Park Wungki, Rycroft Daniel, Nannapaneni Sreenivas, Wang Yuxiang, Chen Zhuo Georgia, Shin Dong M, A dual-targeting antibody against EGFR-VEGF for lung and head and neck cancer treatment. International journal of cancer. Journal international du cancer. 2012; 131(4): 956-69.
Sinha Rajni, Kaufman Jonathan L, Khoury Hanna Jean, King Nassoma, Shenoy Pareen J, Lewis Carol, Bumpers Kevin, Hutchison-Rzepka Amanda, Tighiouart Mourad, Heffner Leonard T, Lechowicz Mary Jo, Lonial Sagar, Flowers Christopher R, A phase 1 dose escalation study of bortezomib combined with rituximab, cyclophosphamide, doxorubicin, modified vincristine, and prednisone for untreated follicular lymphoma and other low-grade B-cell lymphomas. Cancer. 2012; 118(14): 3538-48.
Xu Jing, Müller Susan, Nannapaneni Sreenivas, Pan Lin, Wang Yuxiang, Peng Xianghong, Wang Dongsheng, Tighiouart Mourad, Chen Zhengjia, Saba Nabil F, Beitler Jonathan J, Shin Dong M, Chen Zhuo Georgia, Comparison of quantum dot technology with conventional immunohistochemistry in examining aldehyde dehydrogenase 1A1 as a potential biomarker for lymph node metastasis of head and neck cancer. European journal of cancer (Oxford, England : 1990). 2012; 48(11): 1682-91.
Nagalingam Arumugam, Tighiouart Mourad, Ryden Lisa, Joseph Leena, Landberg Goran, Saxena Neeraj K, Sharma Dipali, Med1 plays a critical role in the development of tamoxifen resistance. Carcinogenesis. 2012; 33(4): 918-30.
Hurwitz Selwyn J, Zhang Hongzheng, Yun Sujin, Batuwangala Thil D, Steward Michael, Holmes Steve D, Rycroft Daniel, Pan Lin, Tighiouart Mourad, Shin Hyung Ju C, Koenig Lydia, Wang Yuxiang, Chen Zhuo Georgia, Shin Dong M, Pharmacodynamics of DT-IgG, a dual-targeting antibody against VEGF-EGFR, in tumor xenografted mice. Cancer chemotherapy and pharmacology. 2012; 69(3): 577-90.
Arellano Martha, Winton Elliott, Pan Lin, Lima Lisa, Tighiouart Mourad, Bhalla Kapil, Heffner Leonard T, Neely Jessica, Hutcherson Donald, McLemore Morgan, Langston Amelia, Khoury H Jean, High-dose cytarabine induction is well tolerated and active in patients with de novo acute myeloid leukemia older than 60 years. Cancer. 2012; 118(2): 428-33.
Thaiparambil Jose T, Bender Laura, Ganesh Thota, Kline Erik, Patel Pritty, Liu Yuan, Tighiouart Mourad, Vertino Paula M, Harvey R Donald, Garcia Anapatricia, Marcus Adam I, Withaferin A inhibits breast cancer invasion and metastasis at sub-cytotoxic doses by inducing vimentin disassembly and serine 56 phosphorylation. International journal of cancer. Journal international du cancer. 2011; 129(11): 2744-55.
Kline Erik R, Muller Susan, Pan Lin, Tighiouart Mourad, Chen Zhuo Georgia, Marcus Adam I, Localization-specific LKB1 loss in head and neck squamous cell carcinoma metastasis. Head & neck. 2011; 33(10): 1501-12.
Arellano Martha, Bernal-Mizrachi Leon, Pan Lin, Tighiouart Mourad, Souza Liliana, Guo Xiangxue, McLemore Morgan, Lima Lisa, Sunay Susan, Heffner Leonard T, Chen Zhengjia, Chen Georgia Zhou, Langston Amelia, Winton Elliott, Khoury H Jean, Prognostic significance of leukopenia at the time of diagnosis in acute myeloid leukemia. Clinical lymphoma, myeloma & leukemia. 2011; 11(5): 427-32.
Wang Xu, Li Jun, Wang Yuxiang, Koenig Lydia, Gjyrezi Ada, Giannakakou Paraskevi, Shin Edwin H, Tighiouart Mourad, Chen Zhuo Georgia, Nie Shuming, Shin Dong M, A folate receptor-targeting nanoparticle minimizes drug resistance in a human cancer model. ACS nano. 2011; 5(8): 6184-94.
Liu Tongrui, Yacoub Rami, Taliaferro-Smith LaTonia D, Sun Shi-Yong, Graham Tisheeka R, Dolan Ryan, Lobo Christine, Tighiouart Mourad, Yang Lily, Adams Amy, O'Regan Ruth M, Combinatorial effects of lapatinib and rapamycin in triple-negative breast cancer cells. Molecular cancer therapeutics. 2011; 10(8): 1460-9.
Lima Lisa M, Sampat Keeran, Assouline Sarit, Saxe Debra, Nault Sharron, Tighiouart Mourad, McLemore Morgan, Arellano Martha, Winton Elliott, Bernal-Mizrachi Leon, Cortes Jorge, Khoury Hanna Jean, Does pretreatment fluorescence in situ hybridization for BCR-ABL predict imatinib-associated hematologic toxicity in chronic myeloid leukemia?. Leukemia & lymphoma. 2011; 52(6): 1010-6.
Lima Lisa, Bernal-Mizrachi Leon, Saxe Debra, Mann Karen P, Tighiouart Mourad, Arellano Martha, Heffner Leonard, McLemore Morgan, Langston Amelia, Winton Elliott, Khoury Hanna Jean, Peripheral blood monitoring of chronic myeloid leukemia during treatment with imatinib, second-line agents, and beyond. Cancer. 2011; 117(6): 1245-52.
Deyrup Andrea T, Miettinen Markku, North Paula E, Khoury Joseph D, Tighiouart Mourad, Spunt Sheri L, Parham David M, Shehata Bahig M, Weiss Sharon W, Pediatric cutaneous angiosarcomas: a clinicopathologic study of 10 cases. The American journal of surgical pathology. 2011; 35(1): 70-5.
Saxena Neeraj K, Fu Ping P, Nagalingam Arumugam, Wang Jason, Handy Jeffrey, Cohen Cynthia, Tighiouart Mourad, Sharma Dipali, Anania Frank A, Adiponectin modulates C-jun N-terminal kinase and mammalian target of rapamycin and inhibits hepatocellular carcinoma. Gastroenterology. 2010; 139(5): 1762-73, 1773.e1-5.
Amin A R M Ruhul, Wang Dongsheng, Zhang Hongzheng, Peng Shifang, Shin Hyung Ju C, Brandes Johann C, Tighiouart Mourad, Khuri Fadlo R, Chen Zhuo Georgia, Shin Dong M, Enhanced anti-tumor activity by the combination of the natural compounds (-)-epigallocatechin-3-gallate and luteolin: potential role of p53. The Journal of biological chemistry. 2010; 285(45): 34557-65.
Akhtari Mojtaba, Giver Cynthia R, Ali Zahir, Flowers Christopher R, Gleason Charise L, Hillyer Christopher D, Kaufman Jonathan, Khoury H Jean, Langston Amelia A, Lechowicz Mary Jo, Lonial Sagar, Renfroe Heather M, Roback John D, Tighiouart Mourad, Vaughn Louette, Waller Edmund K, Receiver operating characteristic curve analysis of circulating blood dendritic cell precursors and T cells predicts response to extracorporeal photopheresis in patients with chronic graft-versus-host disease. Transfusion. 2010; 50(11): 2424-31.
Lonial Sagar, Kaufman Jonathan, Tighiouart Mourad, Nooka Ajay, Langston Amelia A, Heffner Leonard T, Torre Claire, McMillan Stephanie, Renfroe Heather, Harvey R Donald, Lechowicz Mary J, Khoury H Jean, Flowers Christopher R, Waller Edmund K, A phase I/II trial combining high-dose melphalan and autologous transplant with bortezomib for multiple myeloma: a dose- and schedule-finding study. Clinical cancer research : an official journal of the American Association for Cancer Research. 2010; 16(20): 5079-86.
Chen Zhengjia, Krailo Mark D, Azen Stanley P, Tighiouart Mourad, A novel toxicity scoring system treating toxicity response as a quasi-continuous variable in Phase I clinical trials. Contemporary clinical trials. 2010; 31(5): 473-82.
Elrod Heath A, Fan Songqing, Muller Susan, Chen Georgia Z, Pan Lin, Tighiouart Mourad, Shin Dong M, Khuri Fadlo R, Sun Shi-Yong, Analysis of death receptor 5 and caspase-8 expression in primary and metastatic head and neck squamous cell carcinoma and their prognostic impact. PloS one. 2010; 5(8): e12178.
Wang Haibin, Bouzyk Erik, Kuehn Anna, Muller Susan, Chen Zhengjia, Khuri Fadlo R, Shin Dong M, Rogatko André, Tighiouart Mourad, caGrid-Enabled caBIG Silver Level Compatible Head and Neck Cancer Tissue Database System. The open medical informatics journal. 2010; 4(5): 171-8.
Ramalingam Suresh S, Harvey R Donald, Saba Nabil, Owonikoko Taofeek K, Kauh John, Shin Dong M, Sun Shi-Yong, Strychor Sandra, Tighiouart Mourad, Egorin Merrill J, Fu Haian, Khuri Fadlo R, Phase 1 and pharmacokinetic study of everolimus, a mammalian target of rapamycin inhibitor, in combination with docetaxel for recurrent/refractory nonsmall cell lung cancer. Cancer. 2010; 116(16): 3903-9.
Korah Mariam P, Esiashvili Natia, Mazewski Claire M, Hudgins Roger J, Tighiouart Mourad, Janss Anna J, Schwaibold Frederick P, Crocker Ian R, Curran Walter J, Marcus Robert B, Incidence, risks, and sequelae of posterior fossa syndrome in pediatric medulloblastoma. International journal of radiation oncology, biology, physics. 2010; 77(1): 106-12.
Saba Nabil F, Edelman Scott, Tighiouart Mourad, Gaultney Jennifer, Davis Lawrence W, Khuri Fadlo R, Chen Amy, Grist William, Shin Dong M, Concurrent chemotherapy with intensity-modulated radiation therapy for locally advanced squamous cell carcinoma of the larynx and oropharynx: a retrospective single-institution analysis. Head & neck. 2009; 31(11): 1447-55.
Wang Xu, Li Jun, Wang Yiqing, Cho Kwang Jae, Kim Gloria, Gjyrezi Ada, Koenig Lydia, Giannakakou Paraskevi, Shin Hyung Ju C, Tighiouart Mourad, Nie Shuming, Chen Zhuo Georgia, Shin Dong M, HFT-T, a targeting nanoparticle, enhances specific delivery of paclitaxel to folate receptor-positive tumors. ACS nano. 2009; 3(10): 3165-74.
Klass Carmen M, Choe Mi Sun, Hurwitz Selwyn J, Tighiouart Mourad, Zhang Xin, Chen Zhuo Georgia, Shin Dong M, Sequence dependence of cell growth inhibition by EGFR-tyrosine kinase inhibitor ZD1839, docetaxel, and cisplatin in head and neck cancer. Head & neck. 2009; 31(10): 1263-73.
Saba Nabil F, Choi Misun, Muller Susan, Shin Hyung Ju C, Tighiouart Mourad, Papadimitrakopoulou Vassiliki A, El-Naggar Adel K, Khuri Fadlo R, Chen Zhuo Georgia, Shin Dong M, Role of cyclooxygenase-2 in tumor progression and survival of head and neck squamous cell carcinoma. Cancer prevention research (Philadelphia, Pa.). 2009; 2(9): 823-9.
Gatcombe Heather G, Marcus R B, Katzenstein Howard M, Tighiouart Mourad, Esiashvili Natia, Excellent local control from radiation therapy for high-risk neuroblastoma. International journal of radiation oncology, biology, physics. 2009; 74(5): 1549-54.
Saba Nabil F, Wang Xu, Müller Susan, Tighiouart Mourad, Cho Kwangjae, Nie Shuming, Chen Zhuo, Shin Dong M, Examining expression of folate receptor in squamous cell carcinoma of the head and neck as a target for a novel nanotherapeutic drug. Head & neck. 2009; 31(4): 475-81.
Deyrup Andrea T, Miettinen Markku, North Paula E, Khoury Joseph D, Tighiouart Mourad, Spunt Sheri L, Parham David, Weiss Sharon W, Shehata Bahig M, Angiosarcomas arising in the viscera and soft tissue of children and young adults: a clinicopathologic study of 15 cases. The American journal of surgical pathology. 2009; 33(2): 264-9.
Ventii Karen H, Devi Narra S, Friedrich Kenneth L, Chernova Tatiana A, Tighiouart Mourad, Van Meir Erwin G, Wilkinson Keith D, BRCA1-associated protein-1 is a tumor suppressor that requires deubiquitinating activity and nuclear localization. Cancer research. 2008; 68(17): 6953-62.
Zhang Xin, Zhang Hongzheng, Tighiouart Mourad, Lee John E, Shin Hyung J, Khuri Fadlo R, Yang Chung S, Chen Zhuo ' Georgia ', Shin Dong M, Synergistic inhibition of head and neck tumor growth by green tea (-)-epigallocatechin-3-gallate and EGFR tyrosine kinase inhibitor. International journal of cancer. Journal international du cancer. 2008; 123(5): 1005-14.
Muller Susan, Su Ling, Tighiouart Mourad, Saba Nabil, Zhang Hongzheng, Shin Dong M, Chen Zhuo Georgia, Distinctive E-cadherin and epidermal growth factor receptor expression in metastatic and nonmetastatic head and neck squamous cell carcinoma: predictive and prognostic correlation. Cancer. 2008; 113(1): 97-107.
Deyrup Andrea T, Tighiouart Mourad, Montag Anthony G, Weiss Sharon W, Epithelioid hemangioendothelioma of soft tissue: a proposal for risk stratification based on 49 cases. The American journal of surgical pathology. 2008; 32(6): 924-7.
Graham Tisheeka R, Zhau Haiyen E, Odero-Marah Valerie A, Osunkoya Adeboye O, Kimbro K Sean, Tighiouart Mourad, Liu Tongrui, Simons Jonathan W, O'Regan Ruth M, Insulin-like growth factor-I-dependent up-regulation of ZEB1 drives epithelial-to-mesenchymal transition in human prostate cancer cells. Cancer research. 2008; 68(7): 2479-88.
Deyrup Andrea T, McKenney Jesse K, Tighiouart Mourad, Folpe Andrew L, Weiss Sharon W, Sporadic cutaneous angiosarcomas: a proposal for risk stratification based on 69 cases. The American journal of surgical pathology. 2008; 32(1): 72-7.
Rogatko André, Schoeneck David, Jonas William, Tighiouart Mourad, Khuri Fadlo R, Porter Alan, Translation of innovative designs into phase I trials. Journal of clinical oncology : official journal of the American Society of Clinical Oncology. 2007; 25(31): 4982-6.
Post Dawn E, Sandberg Eric M, Kyle Michele M, Devi Narra Sarojini, Brat Daniel J, Xu Zhiheng, Tighiouart Mourad, Van Meir Erwin G, Targeted cancer gene therapy using a hypoxia inducible factor dependent oncolytic adenovirus armed with interleukin-4. Cancer research. 2007; 67(14): 6872-81.
Schnoll Robert A, Engstrom Paul F, Subramanian Somasundaram, Demidov Lev, Wielt Dustin B, Tighiouart Mourad, Prevalence and correlates of tobacco use among Russian cancer patients: implications for the development of smoking cessation interventions at a cancer center in Russia. International journal of behavioral medicine. 2006; 13(1): 16-25.
Rogatko André, Babb James S, Tighiouart Mourad, Khuri Fadlo R, Hudes Gary, New paradigm in dose-finding trials: patient-specific dosing and beyond phase I. Clinical cancer research : an official journal of the American Association for Cancer Research. 2005; 11(15): 5342-6.
Kim Edward S, Kies Merrill S, Fossella Frank V, Glisson Bonnie S, Zaknoen Sara, Statkevich Paul, Munden Reginald F, Summey Carmen, Pisters Katherine M W, Papadimitrakopoulou Vali, Tighiouart Mourad, Rogatko Andre, Khuri Fadlo R, Phase II study of the farnesyltransferase inhibitor lonafarnib with paclitaxel in patients with taxane-refractory/resistant nonsmall cell lung carcinoma. Cancer. 2005; 104(3): 561-9.
Tighiouart Mourad, Rogatko André, Babb James S, Flexible Bayesian methods for cancer phase I clinical trials. Dose escalation with overdose control. Statistics in medicine. 2005; 24(14): 2183-96.