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Xiuqing Guo, Ph.D. [ Edit Your Profile ]

Work Email Address: xguo@labiomed.org

Work Phone Number: 310-974-9516

Work Address:
1124 West Carson Street
torrance, CA 90502

Work
CTSI Investigator, Biostatistics, Epidemiology and Research Design
Harbor UCLA Medical Center Director, Mathematical and Statistical Genetics Professor, Department of Pediatrics

Research Interests

Genetics, Genetics-Human Genetics


Education:
Degrees:
Ph.D., Case Western Reserve University, 1994 - 1998
M.S., Lousiana State University Medical Center, 1994
B.S., Beijing Normal University, 1981 - 1985

About

Dr. Xiuqing Guo is an Assistant Director, Mathematical Genetics at Cedars-Sinai Medical Genetics Institute and an Associate Professor of Pediatrics with expertise in genomic studies and genetic epidemiology. Her research interests have been in pure methodology development to address basic mathematical and biostatistical problems; in solving problems related to gene mapping studies, especially for complex diseases; and data analysis of genetic epidemiologic studies of common, genetically complex diseases, with an emphasis on cardiovascular and metabolic diseases. With the rapid development of molecular techniques, it has become more and more challenging and motivating to develop better statistical methods and apply the appropriate methods to the relevant problem of elucidating the underlying genes for common genetic complex diseases. As an example of Dr. Guo's theoretical work, continuing with early methodology development work in two-stage global search designs for linkage studies, she has recently been working on the methodology development for large scale association studies. She has proposed an Iterative Bayesian Variable Selection Method for analyzing binary traits when sample size is much smaller than number of variables, as is the case in genome-wide association studies. As examples of data analysis, she has led the IRAS Family statistical analyses of the Cedars-Sinai site, including serving as the lead on the linkage analysis of our adiponectin data, and she serves as the lead analyst for all MESA statistical analyses at Cedars-Sinai, including serving as the lead analyst for a number of MESA SHARe working groups such as blood pressure, diabetes and metabolic syndrome, and left ventricular structure and function. Dr. Guo's role on the Biostatistics, Study Design and Clinical Data Management Program (BSD-CDM) will be to develop novel statistical applications and methodologies to address the complexities of biological data and the challenges of community-based research, specifically in High-throughput biological data analysis research.

Publications
Wassel Christina L, Pankow James S, Rasmussen-Torvik Laura J, Li Na, Taylor Kent D, Guo Xiuqing, Goodarzi Mark O, Palmas Walter R, Post Wendy S, Associations of SNPs in ADIPOQ and Subclinical Cardiovascular Disease in the Multi-Ethnic Study of Atherosclerosis (MESA). Obesity (Silver Spring, Md.). 2010; 44(8): .
McGovern Dermot P B, Jones Michelle R, Taylor Kent D, Marciante Kristin, Yan Xiaofei, Dubinsky Marla, Ippoliti Andy, Vasiliauskas Eric, Berel Dror, Derkowski Carrie, Dutridge Deb, Fleshner Phil, Shih David Q, Melmed Gil, Mengesha Emebet, King Lily, Pressman Sheila, Haritunians Talin, Guo Xiuqing, Targan Stephan R, Rotter Jerome I, Rotter Jerome I, Fucosyltransferase 2 (FUT2) non-secretor status is associated with Crohn's disease. Human molecular genetics. 2010; 19(17): 3468-76.
Haritunians Talin, Taylor Kent D, Targan Stephan R, Dubinsky Marla, Ippoliti Andrew, Kwon Soonil, Guo Xiuqing, Melmed Gil Y, Berel Dror, Mengesha Emebet, Psaty Bruce M, Glazer Nicole L, Vasiliauskas Eric A, Rotter Jerome I, Fleshner Phillip R, McGovern Dermot P B, Genetic predictors of medically refractory ulcerative colitis. Inflammatory bowel diseases. 2010; 16(11): 1830-40.
Ishimori Mariko L, Altman Roy D, Cohen Myles J, Cui Jinrui, Guo Xiuqing, Rotter Jerome I, Weisman Michael H, Heritability patterns in hand osteoarthritis: the role of osteophytes. Arthritis research & therapy. 2010; 12(5): R180.
Goodarzi Mark O, Taylor Kent D, Guo Xiuqing, Hokanson John E, Haffner Steven M, Cui Jinrui, Chen Yii-Der I, Wagenknecht Lynne E, Bergman Richard N, Rotter Jerome I, Haplotypes in the lipoprotein lipase gene influence fasting insulin and discovery of a new risk haplotype. The Journal of clinical endocrinology and metabolism. 2007; 92(1): 293-6.
Goodarzi Mark O, Cui Jinrui, Chen Yii-Der I, Hsueh Willa A, Guo Xiuqing, Rotter Jerome I, Fasting insulin reflects heterogeneous physiological processes: role of insulin clearance. American journal of physiology. Endocrinology and metabolism. 2011; 301(2): E402-8.
Goodarzi Mark O, Shah Nissar A, Antoine Heath J, Pall Marita, Guo Xiuqing, Azziz Ricardo, Variants in the 5alpha-reductase type 1 and type 2 genes are associated with polycystic ovary syndrome and the severity of hirsutism in affected women. The Journal of clinical endocrinology and metabolism. 2006; 91(10): 4085-91.
Goodarzi Mark O, Wong Howard, Quiñones Manuel J, Taylor Kent D, Guo Xiuqing, Castellani Lawrence W, Antoine Heath J, Yang Huiying, Hsueh Willa A, Rotter Jerome I, The 3' untranslated region of the lipoprotein lipase gene: haplotype structure and association with post-heparin plasma lipase activity. The Journal of clinical endocrinology and metabolism. 2005; 90(8): 4816-23.
Guo Xiuqing, Cui Jinrui, Wagenknecht Lynne E, Norris Jill M, Haffner Steven M, Darwin Christine, Jinagouda Sujata, Rotter Jerome I, Saad Mohammed F, Cosegregation of albuminuria and blood pressure: the Insulin Resistance Atherosclerosis (IRAS) family study. American journal of hypertension. 2005; 18(6): 823-7.
Goodarzi Mark O, Taylor Kent D, Guo Xiuqing, Quiñones Manuel J, Cui Jinrui, Li Xiaohui, Hang Tieu, Yang Huiying, Holmes Edward, Hsueh Willa A, Olefsky Jerrold, Rotter Jerome I, Variation in the gene for muscle-specific AMP deaminase is associated with insulin clearance, a highly heritable trait. Diabetes. 2005; 54(4): 1222-7.
Guo Xiuqing, Cheng Suzanne, Taylor Kent D, Cui Jinrui, Hughes Randall, Quiñones Manuel J, Bulnes-Enriquez Isabel, De la Rosa Roxana, Aurea George, Yang Huiying, Hsueh Willa, Rotter Jerome I, Hypertension genes are genetic markers for insulin sensitivity and resistance. Hypertension. 2005; 45(4): 799-803.
Graham John M, Gomez Mayela, Halberg Andy, Earl Dawn L, Kreutzman Jeannie T, Cui Jinrui, Guo Xiuqing, Management of deformational plagiocephaly: repositioning versus orthotic therapy. The Journal of pediatrics. 2005; 146(2): 258-62.
Goodarzi Mark O, Louwers Yvonne V, Taylor Kent D, Jones Michelle R, Cui Jinrui, Kwon Soonil, Chen Yii-Der I, Guo Xiuqing, Stolk Lisette, Uitterlinden André G, Laven Joop S E, Azziz Ricardo, Replication of association of a novel insulin receptor gene polymorphism with polycystic ovary syndrome. Fertility and sterility. 2011; 95(5): 1736-41.e1-11.
Graham John M, Kreutzman Jeannie, Earl Dawn, Halberg Andy, Samayoa Carlos, Guo Xiuqing, Deformational brachycephaly in supine-sleeping infants. The Journal of pediatrics. 2005; 146(2): 253-7.
Goodarzi Mark O, Guo Xiuqing, Taylor Kent D, Quiñones Manuel J, Saad Mohammad F, Yang Huiying, Hsueh Willa A, Rotter Jerome I, Lipoprotein lipase is a gene for insulin resistance in Mexican Americans. Diabetes. 2004; 53(1): 214-20.
Li Xiaohui, Wang Dai, Yang Kai, Guo Xiuqing, Lin Ying-Chao, Samayoa Carlos G, Yang Huiying, Genome-wide linkage analysis using cross-sectional and longitudinal traits for body mass index in a subsample of the Framingham Heart Study. BMC genetics. 2003; 4 Suppl 1(1): S35.
Wang Dai, Li Xiaohui, Lin Ying-Chao, Yang Kai, Guo Xiuqing, Yang Huiying, Yang Huiying, Power of linkage analysis using traits generated from simulated longitudinal data of the Framingham Heart Study. BMC genetics. 2003; 4 Suppl 1(1): S28.
Wong Anna K, Fang Belle, Zhang Ling, Guo Xiuqing, Lee Stephen, Schreck Rhona, Loss of the Y chromosome: an age-related or clonal phenomenon in acute myelogenous leukemia/myelodysplastic syndrome?. Archives of pathology & laboratory medicine. 2008; 132(8): 1329-32.
Goodarzi Mark O, Guo Xiuqing, Taylor Kent D, Quiñones Manuel J, Samayoa Carlos, Yang Huiying, Saad Mohammad F, Palotie Aarno, Krauss Ronald M, Hsueh Willa A, Rotter Jerome I, Determination and use of haplotypes: ethnic comparison and association of the lipoprotein lipase gene and coronary artery disease in Mexican-Americans. Genetics in medicine : official journal of the American College of Medical Genetics. 2003; 5(4): 322-7.
Guo Xiuqing, Olson Jane M, Elston Robert C, Niu Tianhua, The linkage information content value of polymorphism genetic markers in model-free linkage analysis. Human heredity. 2002; 53(1): 45-8.
Goodarzi Mark O, Guo Xiuqing, Yildiz Bulent O, Stanczyk Frank Z, Azziz Ricardo, Correlation of adrenocorticotropin steroid levels between women with polycystic ovary syndrome and their sisters. American journal of obstetrics and gynecology. 2007; 196(4): 398.e1-5; discussion 398.e5-6.
Mei Ling, Li Xiaohui, Yang Kai, Cui Jinrui, Fang Belle, Guo Xiuqing, Rotter Jerome I, Evaluating gene x gene and gene x smoking interaction in rheumatoid arthritis using candidate genes in GAW15. BMC proceedings. 2007; 1 Suppl 1(4): S17.
Kwon Soonil, Yan Xiaofei, Cui Jinrui, Yao Jie, Yang Kai, Tsiang Donald, Li Xiaohui, Rotter Jerome I, Guo Xiuqing, Application of Bayesian regression with singular value decomposition method in association studies for sequence data. BMC proceedings. 2011; 5 Suppl 9(10): S57.
Pojoga Luminita H, Underwood Patricia C, Goodarzi Mark O, Williams Jonathan S, Adler Gail K, Jeunemaitre Xavier, Hopkins Paul N, Raby Benjamin A, Lasky-Su Jessica, Sun Bei, Cui Jinrui, Guo Xiuqing, Taylor Kent D, Chen Yii-Der Ida, Xiang Anny, Raffel Leslie J, Buchanan Thomas A, Rotter Jerome I, Williams Gordon H, Variants of the caveolin-1 gene: a translational investigation linking insulin resistance and hypertension. The Journal of clinical endocrinology and metabolism. 2011; 96(8): E1288-92.
Sheu Wayne H-H, Kuo Jane Z, Lee I-Te, Hung Yi-Jen, Lee Wen-Jane, Tsai Hin-Yeung, Wang J-S, Goodarzi Mark O, Klein Ronald, Klein Barbara E K, Ipp Eli, Lin Shin-Yi, Guo Xiuqing, Hsieh Chang-Hsun, Taylor Kent D, Fu Chia-Po, Rotter Jerome I, Chen Yii-Der I, Genome-wide association study in a Chinese population with diabetic retinopathy. Human molecular genetics. 2013; 45(6): .
Huertas-Vazquez Adriana, Nelson Christopher P, Guo Xiuqing, Reinier Kyndaron, Uy-Evanado Audrey, Teodorescu Carmen, Ayala Jo, Jerger Katherine, Chugh Harpriya, Chugh Harpriya, Braund Peter S, Deloukas Panos, Hall Alistair S, Balmforth Anthony J, Jones Michelle, Taylor Kent D, Pulit Sara L, Newton-Cheh Christopher, Gunson Karen, Jui Jonathan, Rotter Jerome I, Albert Christine M, Samani Nilesh J, Chugh Sumeet S, Novel loci associated with increased risk of sudden cardiac death in the context of coronary artery disease. PloS one. 2013; 8(4): e59905.
Smith Nicholas L, Huffman Jennifer E, Strachan David P, Huang Jie, Dehghan Abbas, Trompet Stella, Lopez Lorna M, Shin So-Youn, Baumert Jens, Vitart Veronique, Bis Joshua C, Wild Sarah H, Rumley Ann, Yang Qiong, Uitterlinden Andre G, Stott David J, Davies Gail, Carter Angela M, Thorand Barbara, Polašek Ozren, McKnight Barbara, Campbell Harry, Rudnicka Alicja R, Chen Ming-Huei, Buckley Brendan M, Harris Sarah E, Peters Annette, Pulanic Drazen, Lumley Thomas, de Craen Anton J M, Liewald David C, Gieger Christian, Campbell Susan, Ford Ian, Gow Alan J, Luciano Michelle, Porteous David J, Guo Xiuqing, Sattar Naveed, Tenesa Albert, Cushman Mary, Slagboom P Eline, Visscher Peter M, Spector Tim D, Illig Thomas, Rudan Igor, Bovill Edwin G, Wright Alan F, McArdle Wendy L, Tofler Geoffrey, Hofman Albert, Westendorp Rudi G J, Starr John M, Grant Peter J, Karakas Mahir, Hastie Nicholas D, Psaty Bruce M, Wilson James F, Lowe Gordon D O, O'Donnell Christopher J, Witteman Jacqueline C M, Jukema J Wouter, Deary Ian J, Soranzo Nicole, Koenig Wolfgang, Hayward Caroline, Genetic predictors of fibrin D-dimer levels in healthy adults. Circulation. 2011; 123(17): 1864-72.
An S Sandy, Palmer Nicholette D, Hanley Anthony J G, Ziegler Julie T, Brown W Mark, Freedman Barry I, Register Thomas C, Rotter Jerome I, Guo Xiuqing, Chen Y-D Ida, Wagenknecht Lynne E, Langefeld Carl D, Bowden Donald W, Genetic analysis of adiponectin variation and its association with type 2 diabetes in african americans. Obesity (Silver Spring, Md.). 2013; 8(4): .
Uhart Magdalena, Weerts Elise M, McCaul Mary E, Guo Xiuqing, Yan Xiaofei, Kranzler Henry R, Li Ning, Wand Gary S, GABRA2 markers moderate the subjective effects of alcohol. Addiction biology. 2013; 18(2): 357-69.
Xu Ning, Kwon Soonil, Abbott David H, Geller David H, Dumesic Daniel A, Azziz Ricardo, Guo Xiuqing, Goodarzi Mark O, Epigenetic mechanism underlying the development of polycystic ovary syndrome (PCOS)-like phenotypes in prenatally androgenized rhesus monkeys. PloS one. 2011; 6(11): e27286.
Shah Sidharth A, Herrington David M, Howard Timothy D, Divers Jasmin, Arnett Donna K, Burke Greg L, Kao Weng Hong, Guo Xiuqing, Siscovick David S, Chakravarti Aravinda, Lima Joao A, Psaty Bruce M, Tomaselli Gordon F, Rich Stephen S, Bowden Donald W, Post Wendy, Associations between NOS1AP single nucleotide polymorphisms (SNPs) and QT interval duration in four racial/ethnic groups in the Multi-Ethnic Study of Atherosclerosis (MESA). Annals of noninvasive electrocardiology : the official journal of the International Society for Holter and Noninvasive Electrocardiology, Inc. 2013; 18(1): 29-40.
An S Sandy, Palmer Nicholette D, Hanley Anthony J G, Ziegler Julie T, Brown W Mark, Haffner Steven M, Norris Jill M, Rotter Jerome I, Guo Xiuqing, Chen Y-D Ida, Wagenknecht Lynne E, Langefeld Carl D, Bowden Donald W, Estimating the contributions of rare and common genetic variations and clinical measures to a model trait: adiponectin. Genetic epidemiology. 2013; 37(1): 13-24.
An S Sandy, Hanley Anthony J G, Ziegler Julie T, Brown W Mark, Haffner Steven M, Norris Jill M, Rotter Jerome I, Guo Xiuqing, Chen Y-D Ida, Wagenknecht Lynne E, Langefeld Carl D, Bowden Donald W, Palmer Nicholette D, Association between ADIPOQ SNPs with plasma adiponectin and glucose homeostasis and adiposity phenotypes in the IRAS Family Study. Molecular genetics and metabolism. 2012; 107(4): 721-8.
Williams Jonathan S, Chamarthi Bindu, Goodarzi Mark O, Pojoga Luminita H, Sun Bei, Garza Amanda E, Raby Benjamin A, Adler Gail K, Hopkins Paul N, Brown Nancy J, Jeunemaitre Xavier, Ferri Claudio, Fang Rui, Leonor Thiago, Cui Jinrui, Guo Xiuqing, Taylor Kent D, Ida Chen Yii-Der, Xiang Anny, Raffel Leslie J, Buchanan Thomas A, Rotter Jerome I, Williams Gordon H, Shi Yujiang, Lysine-specific demethylase 1: an epigenetic regulator of salt-sensitive hypertension. American journal of hypertension. 2012; 25(7): 812-7.
Rasmussen-Torvik Laura J, Guo Xiuqing, Bowden Donald W, Bertoni Alain G, Sale Michele M, Yao Jie, Bluemke David A, Goodarzi Mark O, Chen Y Ida, Vaidya Dhananjay, Raffel Leslie J, Papanicolaou George J, Meigs James B, Pankow James S, Fasting glucose GWAS candidate region analysis across ethnic groups in the Multiethnic Study of Atherosclerosis (MESA). Genetic epidemiology. 2012; 36(4): 384-91.
Kuo Jane Z, Guo Xiuqing, Klein Ronald, Klein Barbara E, Cui Jinrui, Rotter Jerome I, Ipp Eli, Chen Yii-Der Ida, Systemic soluble tumor necrosis factor receptors 1 and 2 are associated with severity of diabetic retinopathy in Hispanics. Ophthalmology. 2012; 119(5): 1041-6.
Kwon Soonil, Goodarzi Mark O, Taylor Kent D, Cui Jinrui, Chen Y-D Ida, Rotter Jerome I, Hsueh Willa, Guo Xiuqing, A Multinomial Ordinal Probit Model with Singular Value Decomposition Method for a Multinomial Trait. Journal of probability and statistics. 2012; 2012(5): .
Manichaikul Ani, Palmas Walter, Rodriguez Carlos J, Peralta Carmen A, Divers Jasmin, Guo Xiuqing, Chen Wei-Min, Wong Quenna, Williams Kayleen, Kerr Kathleen F, Taylor Kent D, Tsai Michael Y, Goodarzi Mark O, Sale Michèle M, Diez-Roux Ana V, Rich Stephen S, Rotter Jerome I, Mychaleckyj Josyf C, Population structure of Hispanics in the United States: the multi-ethnic study of atherosclerosis. PLoS genetics. 2012; 8(4): e1002640.
Aslibekyan Stella, Goodarzi Mark O, Frazier-Wood Alexis C, Yan Xiaofei, Irvin Marguerite R, Kim Eric, Tiwari Hemant K, Guo Xiuqing, Straka Robert J, Taylor Kent D, Tsai Michael Y, Hopkins Paul N, Korenman Stanley G, Borecki Ingrid B, Chen Yii-Der I, Ordovas Jose M, Rotter Jerome I, Arnett Donna K, Variants identified in a GWAS meta-analysis for blood lipids are associated with the lipid response to fenofibrate. PloS one. 2012; 7(10): e48663.