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Christopher T. Denny, M.D. [ Edit Your Profile ]

Work Email Address: cdenny@ucla.edu

Work Phone Number: (310) 825-0704

Laboratory Address:
700 Westwood Blvd
Los Angeles, CA 90095

Office Address:
10-240
CAMPUS - 175217
CA

Work
UCLA Professor, Pediatric Hematology/Oncology Professor, Pediatrics Research Director, Pediatric Hematology/Oncology

Research Interests

Pediatrics, Pediatrics - Pediatric


Education:
Degrees:
M.D., University of Pennsylvania, Philadelphia, PA, 1976 - 1980
B.S., University of Pennsylvania, Philadelphia, PA, 1972 - 1976
Fellowship:
1983 - 1987 National Institutes of Health, The Clinical Center
Internship:
1980 - 1981 Children's Hospital National Medical Center
Residency:
1981 - 1983 Children's Hospital National Medical Center

Certifications:
Certifications:
1990 American Board of Pediatrics
1986 American Board of Pediatrics

About

Throughout Dr. Christopher Denny's 23-year research career at UCLA, his greatest creative potential has been in forging links between diverse fields. Most of his academic success has come through applying basic molecular biology tools to seek molecular mechanisms for what he witnesses when treating pediatric oncology patients. More recently in an effort to have a more immediate impact on clinical oncology, his lab has embarked on a new translational project aimed at testing tumor-targeting strategies using nanoparticles. His lab provides a translational environment where both MD postgraduates and PhD students work side by side and directly interact with each other. His experience in co-directing an active Microarray core for the Jonsson Comprehensive Cancer Center has given him first hand insight into the requirements for successfully operating such facilities. Furthermore working as co-director of the Computer Technology Research Lab has given him first hand knowledge of how to develop the web-accessable tools that will be integral to connecting translational investigators to technology cores. The sum of these experiences uniquely qualifies him for leading the Center for Translational Technology (CTT) program in the UCLA CTSI.

Publications
Federman Noah, Chan Jason, Nagy Jon O, Landaw Elliot M, McCabe Katelyn, Wu Anna M, Triche Timothy, Kang Hyunggyoo, Liu Bin, Marks James D, Denny Christopher T, Enhanced growth inhibition of osteosarcoma by cytotoxic polymerized liposomal nanoparticles targeting the alcam cell surface receptor. Sarcoma. 2012; 2012: 126906.
Anderson Jennifer L, Denny Christopher T, Tap William D, Federman Noah, Pediatric Sarcomas: Translating Molecular Pathogenesis of Disease to Novel Therapeutic Possibilities. Pediatric research. 2012; .
France Kelly A, Anderson Jennifer L, Park Ann, Denny Christopher T, Oncogenic fusion protein EWS/FLI1 down-regulates gene expression by both transcriptional and posttranscriptional mechanisms. The Journal of biological chemistry. 2011; 286(26): 22750-7.
Ikeda Alan K, Judelson Dejah R, Federman Noah, Glaser Keith B, Landaw Elliot M, Denny Christopher T, Sakamoto Kathleen M, ABT-869 inhibits the proliferation of Ewing Sarcoma cells and suppresses platelet-derived growth factor receptor beta and c-KIT signaling pathways. Molecular cancer therapeutics. 2010; 9(3): 653-60.
Federman Noah, Denny Christopher T, Targeting liposomes toward novel pediatric anticancer therapeutics. Pediatric research. 2010; 67(5): 514-9.
Hicks Christopher M, Bandiera Glen W, Denny Christopher J, Building a simulation-based crisis resource management course for emergency medicine, phase 1: Results from an interdisciplinary needs assessment survey. Academic emergency medicine : official journal of the Society for Academic Emergency Medicine. 2008; 15(11): 1136-43.
Potikyan Gary, France Kelly A, Carlson Marc R J, Dong Jun, Nelson Stanley F, Denny Christopher T, Genetically defined EWS/FLI1 model system suggests mesenchymal origin of Ewing's family tumors. Laboratory investigation; a journal of technical methods and pathology. 2008; 88(12): 1291-302.
Potikyan Gary, Savene Rupert O V, Gaulden Julie M, France Kelly A, Zhou Zhichao, Kleinerman Eugenie S, Lessnick Stephen L, Denny Christopher T, EWS/FLI1 regulates tumor angiogenesis in Ewing's sarcoma via suppression of thrombospondins. Cancer research. 2007; 67(14): 6675-84.
Ng King Pan, Potikyan Gary, Savene Rupert OV, Denny Christopher T, Uversky Vladimir N, Lee Kevin AW, Multiple aromatic side chains within a disordered structure are critical for transcription and transforming activity of EWS family oncoproteins. Proc. Natl. Acad. Sci. U.S.A. 2007; 104(2): 479-84.
Kim Sungeun, Denny Christopher T, Wisdom Ron, Cooperative DNA binding with AP-1 proteins is required for transformation by EWS-Ets fusion proteins. Molecular and cellular biology. 2006; 26(7): 2467-78.
Davis Ian J, Kim Jessica J, Ozsolak Fatih, Widlund Hans R, Rozenblatt-Rosen Orit, Granter Scott R, Du Jinyan, Fletcher Jonathan A, Denny Christopher T, Lessnick Stephen L, Linehan W Marston, Kung Andrew L, Fisher David E, Oncogenic MITF dysregulation in clear cell sarcoma: defining the MiT family of human cancers. Cancer cell. 2006; 9(6): 473-84.
Deneen Benjamin, Hamidi Habib, Denny Christopher T, Functional analysis of the EWS/ETS target gene uridine phosphorylase. Cancer research. 2003; 63(14): 4268-74.
Denny Christopher J, Steinhart Brian D, Yu Richard, Improving physician flow and efficiency in the emergency department. CJEM. 2003; 5(4): 271-4.
Deneen Benjamin, Welford Scott M, Ho Thu, Hernandez Felicia, Kurland Irwin, Denny Christopher T, PIM3 proto-oncogene kinase is a common transcriptional target of divergent EWS/ETS oncoproteins. Molecular and cellular biology. 2003; 23(11): 3897-908.
Ho, T. Deneen, B. Denny, C. , Up-regulation of PIM3 may be necessary but not sufficient in the formation of tumors with the characteristics of Ewing's sarcoma family tumors. Journal of Investigative Medicine. 2003; 51: S100-S100.
Foote Simon, Denny Christopher, Construction of YAC libraries with large inserts. Current protocols in human genetics / editorial board, Jonathan L. Haines ... [et al.]. 2002; Chapter 5(4): Unit5.2.
Maris John M, Denny Christopher T, Focus on embryonal malignancies. Cancer cell. 2002; 2(6): 447-50.
Morra, M. Lu, J. Poy, F. Calpe, S. Martin, M. Gullo, C. Howie, D. Denny, C. Engel, P. Eck, M. J. Terhorst, C., The "free SH2-domain" EAT-2 binds CD150-related receptors in hematopoietic cells. Faseb Journal. 2002; 16(4): A321-A321.
Denny, C., Defining small round cell tumors of childhood: When is a rose really a rose. Journal of Pediatric Hematology Oncology. 2001; 23(6): 338-339.
Arvand A, Welford S, Teitell MA, Denny CT, The C-terminal domain of FLI-1 is necesary for full tumorigenic potential of the EWS/FLI1. Cancer Research. 2001; 61: 5311-17.
Welford SM, Gregg J, Chen E, Garrison D, Sorensen PH, Denny CT, Nelson SF, Detection of differentially expressed genes in primary tumor tissues using representational differences analysis coupled to microarray hybridization. Nucleic acids research. 1998; 26(12): 3059-65.
May WA, Arvand A, Thompson AD, Braun BS, Wright M, Denny CT, EWS/FLI1-induced Manic Fringe renders NIH 3T3 cells tumorigenic. Nature Genetics. 1997; 17: 495-498.
Anderson Jennifer L, Park Ann, Akiyama Ryan, Tap William D, Denny Christopher T, Federman Noah, Evaluation of In Vitro Activity of the Class I PI3K Inhibitor Buparlisib (BKM120) in Pediatric Bone and Soft Tissue Sarcomas. PloS one. 2015; 10(9): e0133610.
Anderson Jennifer L, Titz Björn, Akiyama Ryan, Komisopoulou Evangelia, Park Ann, Tap William D, Graeber Thomas G, Denny Christopher T, Phosphoproteomic profiling reveals IL6-mediated paracrine signaling within the Ewing sarcoma family of tumors. Molecular cancer research : MCR. 2014; 12(12): 1740-54.
Denny Christopher T, ChIP-ping away at EWS/ETS transcription networks. Cancer cell. 2014; 26(5): 595-6.