Stats/Methods/Informatics - Biostatistics and/or Biometry; Medicine - Oncology
André Rogatko, PhD is Associate Director of the Samuel Oschin Comprehensive Cancer Institute for Biostatistics. Dr. Rogatko came to Cedars-Sinai with substantial experience, including serving as:
-Associate Director of Biostatistics at the Winship Cancer Institute -Professor in the Department of Biostatistics at The Rollins School of Public Health -Professor in the Department of Hematology and Oncology at School of Medicine, Emory University -Chairman of the Department of Biostatistics at the Fox Chase Cancer Center and Director of the Biostatistics Facility. He joined the Fox Chase Cancer Center as Associate Member in 1992 and was promoted to Member with tenure in 1995 and Chairman of the Department of Biostatistics on January 4, 1999 -He has had appointments at the International Agency for Research on Cancer (World Health Organization, Lyon, 1990-1992) and Memorial Sloan-Kettering Cancer Center (1985-1990)
Dr. Rogatko has more than 100 published peer-reviewed articles, book chapters and computer applications in biostatistics and genetic epidemiology and is a recognized expert in adaptive trials in oncology. He has been developing methodologies to improve the design and provide more efficient analytical tools in phase I/II clinical trials. Notably, he developed a new approach for dose escalation in phase I clinical trials, referred to as EWOC (Escalation With Overdose Control). As a consequence of his work, more patients are expected to be treated with therapeutically doses of a promising new agent and fewer patients will be overdosed and suffer from its toxic effects. Dr. Rogatko has proposed a new paradigm for the clinical evaluation of new cancer therapies. It entails adjusting the search for the optimal dose on the basis of measurable patient characteristics that may be predictive of adverse responses to treatment, and extending this search beyond phase I and into phases II and III.
Dr. Rogatko has been developing methodology with applications in the areas of segregation analysis, gene mapping, and risk prediction. He has proposed a method for risk prediction with linked markers, and also developed methods to characterize diagnostic tests with multi-valued outcomes. He also proposed methods to construct meiotic gene maps while controlling the probability of a decision-error and also proposed two diagnostics for the statistical assessment of the Hardy-Weinberg equilibrium.
Dr. Rogatko is also further developing research in Patient Characteristics as Predictors of Toxicity to Cancer Treatment. This research project is the first large scale effort to link genetic, pharmacokinetic, and clinical variables for the prediction of toxicity and response to taxane-based chemotherapy. The expected result of this project is that cancer patients will be: (i) more likely to receive therapeutic doses of promising new agents, (ii) less likely to suffer the deleterious effects of toxic doses, and (iii) promising therapies will become available more rapidly.
Dr. Rogatko earned his doctorate degree in Genetics and Statistics, summa cum laude, from Sao Paulo University in Brazil in 1983.