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Leon G. Fine, M.B. [ Edit Your Profile ]

Email Address: leon.fine@cshs.org
Work Email Address: leon.fine@cshs.org

Fax Number: 310-423-0228
Work Phone Number: 310-423-6457

Mailing Address:
8700 Beverly Bl, Rm 5072-Davis
Los Angeles, CA 90048

Work
Cedar-Sinai Medical Center Professor, Division for Biomedical Sciences and Medicine
UCLA Professor, Medicine

Education:
Degrees:
M.B., University of Cape Town, Cape Town, South Africa, 1966
Fellowship:
1972 - 1974 Albert Einstein College of Medicine, Bronx, New York
Internship:
1967 - 1968 Tel Hashomer Hospital and Tel Aviv University Medical School, Israel
Residency:
1968 - 1970 Tel Hashomer Hospital and Tel Aviv University Medical School, Israel

About

Dr. Leon Fine serves as Chair of the Department of Biomedical Sciences and Director of Graduate Research Education at Cedars-Sinai Medical Center. He is a former Dean of the University College of London, and immediate past Harveian Librarian at the Royal College of Physicians. He was Chief of the Division of Nephrology at UCLA from 1978 to 1991. He joined the staff of Cedars-Sinai in 2007, having completed his term as and Chairman of the Department of Medicine and Dean of the Faculty of Clinical Sciences at University College London (UK) from 1991 to 2002. His record of training and mentoring clinician scientists includes serving as Director of an NIH training grant encompassing four UCLA campuses and overseeing a series of NIH physician-scientist awards in his division. As Chief of Medicine and Dean, he was responsible for oversight of career development of junior faculty across multiple disciplines, wrote formal review processes for evaluating progress, and instituted plans for optimizing success in peer-reviewed funding, research networking, and scientific visibility of clinical research scientists. He also presided over a PhD program in the Department of Medicine and a number of Masters degree programs in the School of Medicine. As the Chair of the recently formed Department of Biomedical Sciences, he aims to advance the academic research enterprise, support development of translational and clinical investigators, and provide researchers in the basic biomedical sciences with physician partnerships to accelerate the translation of basic science discoveries towards clinical evaluation and, eventually, clinical practice. Towards this end, he has already achieved several key objectives. Specifically, he has: 1) established the first graduate program at Cedars-Sinai, the PhD Program in Biomedical Sciences and Translational Medicine; 2) developed and deployed a new Clinical Scholars program, which aims to foster development of promising young physician-scientists into independently-funded academic clinical and translational research careers through a program that includes a one year didactic curriculum, mentoring, and institutional financial support for research (16 physician-scientists are currently enrolled); and 3) established the first Cedars-Sinai Professorial Series. He will serve on the CTSI Grants Review Committee that oversees the grants to be funded by the CTSI, help organize Ad Hoc reviewers from Cedars and other partner institutions, oversee Cedars Faculty engagement with the CTSI and participate in collaborative interdisciplinary projects. As a leader of the CTSI Pilot/Collaborative Research Program, he will assist in identifying co-funding opportunities for CTSI grants with Cedars seed grant funding.

Publications
Fine Leon G, Dharmakumar Rohan, Limitations of BOLD-MRI for assessment of hypoxia in chronically diseased human kidneys. Kidney international. 2012; 82(8): 934-5.
Long David A, Norman Jill T, Fine Leon G, Restoring the renal microvasculature to treat chronic kidney disease. Nature reviews. Nephrology. 2012; 8(4): 244-50.
Fine Leon G, First heal thyself: rescue of dysfunctional endothelial progenitor cells restores function to the injured kidney. The American journal of pathology. 2010; 176(4): 1586-7.
Fine Leon G, Norman Jill T, Chronic hypoxia as a mechanism of progression of chronic kidney diseases: from hypothesis to novel therapeutics. Kidney international. 2008; 74(7): 867-72.
Fine Leon G, Primary aldosteronism: renal effects compared with primary hypertension. Nature clinical practice. Nephrology. 2007; 3(2): 70-1.
Fine Leon G, Samuel Johnson's illnesses. Journal of nephrology. 2007; 19 Suppl 10(2): S110-4.
Norman Jill T, Fine Leon G, Intrarenal oxygenation in chronic renal failure. Clinical and experimental pharmacology & physiology. 2006; 33(10): 989-96.
Shakib Kaveh, Norman Jill T, Fine Leon G, Brown Larry R, Godovac-Zimmermann Jasminka, Proteomics profiling of nuclear proteins for kidney fibroblasts suggests hypoxia, meiosis, and cancer may meet in the nucleus. Proteomics. 2005; 5(11): 2819-38.
Fine Leon G, The response to loss of function of one kidney: it all depends upon what is happening next door. Kidney international. 2005; 68(6): 2904-5.
Xu Qihe, Konta Tsuneo, Nakayama Kenji, Furusu Akira, Moreno-Manzano Victoria, Lucio-Cazana Javier, Ishikawa Yoshihisa, Fine Leon G, Yao Jian, Kitamura Masanori, Cellular defense against H2O2-induced apoptosis via MAP kinase-MKP-1 pathway. Free radical biology & medicine. 2004; 36(8): 985-93.
Fine Leon G, Charles Edward Isaacs (1811-1860): exploring the details of nephron structure and function in the post-Bowman period. Journal of nephrology. 2004; 16(5): 774-8.
Xu Qihe, Lucio-Cazana Javier, Kitamura Masanori, Ruan Xiongzhong, Fine Leon G, Norman Jill T, Retinoids in nephrology: promises and pitfalls. Kidney international. 2004; 66(6): 2119-31.
Fine Leon G, The clinical-skills examination. The New England journal of medicine. 2004; 351(5): 507-9; author reply 507-9.
Norman Jill T, Stidwill Ray, Singer Mervyn, Fine Leon G, Angiotensin II blockade augments renal cortical microvascular pO2 indicating a novel, potentially renoprotective action. Nephron. Physiology. 2003; 94(2): p39-46.
Fine Leon G, Keogh Bruce E, Cretin Shan, Orlando Maria, Gould Mairi M, Gould Mairi M, How to evaluate and improve the quality and credibility of an outcomes database: validation and feedback study on the UK Cardiac Surgery Experience. BMJ (Clinical research ed.). 2003; 326(7379): 25-8.
Fine Leon G, Norman Jill T, The breathing kidney. Journal of the American Society of Nephrology : JASN. 2002; 13(7): 1974-6.
Fine Leon G, Norman Jill T, The breathing kidney. Journal of the American Society of Nephrology : JASN. 2002; 13(7): 1974-6.
Xu Qihe, Konta Tsuneo, Furusu Akira, Nakayama Kenji, Lucio-Cazana Javier, Fine Leon G, Kitamura Masanori, Transcriptional induction of mitogen-activated protein kinase phosphatase 1 by retinoids. Selective roles of nuclear receptors and contribution to the antiapoptotic effect. The Journal of biological chemistry. 2002; 277(44): 41693-700.
Fine L G, Caveolar cohabitation. Kidney international. 2001; 59(2): 797-8.
Chen J, Brodsky S, Li H, Hampel D J, Miyata T, Weinstein T, Gafter U, Norman J T, Fine L G, Goligorsky M S, Delayed branching of endothelial capillary-like cords in glycated collagen I is mediated by early induction of PAI-1. American journal of physiology. Renal physiology. 2001; 281(1): F71-80.
Norman J T, Orphanides C, Garcia P, Fine L G, Hypoxia-induced changes in extracellular matrix metabolism in renal cells. Experimental nephrology. 2000; 7(5-6): 463-9.
Fine L G, Bandyopadhay D, Norman J T, Is there a common mechanism for the progression of different types of renal diseases other than proteinuria? Towards the unifying theme of chronic hypoxia. Kidney international. Supplement. 2000; 75(2): S22-6.
Fine L G, British contributions to renal physiology: Of dynasties and diuresis. American journal of nephrology. 1999; 19(2): 257-65.
Kitamura M, Fine L G, Gene transfer into the adult kidney for unravelling disease processes. Experimental nephrology. 1999; 6(5): 429-37.
Newton N M, Fine L G, Inference of the existence of high blood pressure as a cause of renal disease in the mid-19th century: observations on vascular structures in the kidney. American journal of nephrology. 1999; 19(2): 323-32.
Norman J T, Fine L G, Progressive renal disease: fibroblasts, extracellular matrix, and integrins. Experimental nephrology. 1999; 7(2): 167-77.
Kitamura M, Fine L G, The concept of glomerular self-defense. Kidney international. 1999; 55(5): 1639-71.
Fine L G, Clinical experience of UK medical students. Lancet. 1998; 351(9112): 1365.
Kitamura M, Fine L G, Evidence for TGF-beta-mediated 'defense' of the glomerulus: a blackguard molecule rehabilitated?. Experimental nephrology. 1998; 6(1): 1-6.
Fine L G, Orphanides C, Norman J T, Progressive renal disease: the chronic hypoxia hypothesis. Kidney international. Supplement. 1998; 65(9112): S74-8.
Fine L G, Gene therapy for human renal disease? Don't catch your zinc finger in your leucine zipper. American journal of kidney diseases : the official journal of the National Kidney Foundation. 1997; 30(1): xliv-xlviii.
Kitamura M, Fine L G, Gene transfer into the kidney: promises and limitations. Kidney international. Supplement. 1997; 60(3): S86-90.
Kitamura M, Fine L G, Genetic manipulation of the kidney. Pediatric nephrology (Berlin, Germany). 1997; 11(6): 773-7.
Orphanides C, Fine L G, Norman J T, Hypoxia stimulates proximal tubular cell matrix production via a TGF-beta1-independent mechanism. Kidney international. 1997; 52(3): 637-47.
Sütö T S, Fine L G, Shimizu F, Kitamura M, In vivo transfer of engineered macrophages into the glomerulus: endogenous TGF-beta-mediated defense against macrophage-induced glomerular cell activation. Journal of immunology (Baltimore, Md. : 1950). 1997; 159(5): 2476-83.
Andreae L, Fine L G, Unravelling dropsy: from Marcello Malpighi's discovery of the capillaries (1661) to Stephen Hales' production of oedema in an experimental model (1733). American journal of nephrology. 1997; 17(3-4): 359-68.
Kitamura M, Burton S, Yokoo T, Fine L G, Gene delivery into the renal glomerulus by transfer of genetically engineered, autologous mesangial cells. Experimental nephrology. 1996; 4(1): 56-9.
Fine L G, Gene transfer into the kidney: promise for unravelling disease mechanisms, limitations for human gene therapy. Kidney international. 1996; 49(3): 612-9.
Sütö T S, Fine L G, Kitamura M, Mesangial cell-derived transforming growth factor-beta 1 reduces macrophage adhesiveness with consequent deactivation. Kidney international. 1996; 50(2): 445-52.
Lewis M P, Fine L G, Norman J T, Pexicrine effects of basement membrane components on paracrine signaling by renal tubular cells. Kidney international. 1996; 49(1): 48-58.
Kitamura M, Sütö T, Yokoo T, Shimizu F, Fine L G, Transforming growth factor-beta 1 is the predominant paracrine inhibitor of macrophage cytokine synthesis produced by glomerular mesangial cells . Journal of immunology (Baltimore, Md. : 1950). 1996; 156(8): 2964-71.
Ong A C, Jowett T P, Firth J D, Burton S, Karet F E, Fine L G, An endothelin-1 mediated autocrine growth loop involved in human renal tubular regeneration. Kidney international. 1995; 48(2): 390-401.
Fine L G, Norman J T, Ong A, Cell-cell cross-talk in the pathogenesis of renal interstitial fibrosis. Kidney international. Supplement. 1995; 49(2): S48-50.
Woolf A S, Kolatsi-Joannou M, Hardman P, Andermarcher E, Moorby C, Fine L G, Jat P S, Noble M D, Gherardi E, Roles of hepatocyte growth factor/scatter factor and the met receptor in the early development of the metanephros. The Journal of cell biology. 1995; 128(1-2): 171-84.
Kitamura M, Burton S, English J, Kawachi H, Fine L G, Transfer of a mutated gene encoding active transforming growth factor-beta 1 suppresses mitogenesis and IL-1 response in the glomerulus. Kidney international. 1995; 48(6): 1747-57.
Fine L G, William Bowman's description of the microscopic anatomy of the kidney. Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association. 1995; 10(11): 2147-9.
Kitamura M, Taylor S, Unwin R, Burton S, Shimizu F, Fine L G, Gene transfer into the rat renal glomerulus via a mesangial cell vector: site-specific delivery, in situ amplification, and sustained expression of an exogenous gene in vivo. The Journal of clinical investigation. 1994; 94(2): 497-505.
Ong A C, Jowett T P, Firth J D, Burton S, Kitamura M, Fine L G, Human tubular-derived endothelin in the paracrine regulation of renal interstitial fibroblast function. Experimental nephrology. 1994; 2(2): 134.
Fine L G, English J A, John Blackall (1771-1860): failure to see the obvious in dropsical patients with coagulable urine?. American journal of nephrology. 1994; 14(4-6): 371-6.
Ong A C, Fine L G, Loss of glomerular function and tubulointerstitial fibrosis: cause or effect?. Kidney international. 1994; 45(2): 345-51.
Ong A C, Fine L G, Tubular-derived cytokines and human renal disease progression. Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association. 1994; 9(5): 471-2.
Ong A C, Fine L G, Tubular-derived growth factors and cytokines in the pathogenesis of tubulointerstitial fibrosis: implications for human renal disease progression. American journal of kidney diseases : the official journal of the National Kidney Foundation. 1994; 23(2): 205-9.
Bosch R J, Woolf A S, Fine L G, Gene transfer into the mammalian kidney: direct retrovirus-transduction of regenerating tubular epithelial cells. Experimental nephrology. 1993; 1(1): 49-54.
Woolf A S, Bosch R J, Fine L G, Gene transfer into the mammalian kidney: first steps towards renal gene therapy. Kidney international. Supplement. 1993; 39(1): S116-9.
Woolf A S, Bosch R J, Fine L G, Gene transfer into the mammalian kidney: microtransplantation of retrovirus-transduced metanephric tissue. Experimental nephrology. 1993; 1(1): 41-8.
Woolf A S, Fine L G, Genetically engineered kidneys. Pediatric nephrology (Berlin, Germany). 1993; 7(5): 605-8.
Fine L G, Ong A C, Norman J T, Mechanisms of tubulo-interstitial injury in progressive renal diseases. European journal of clinical investigation. 1993; 23(5): 259-65.
Fine L G, Hammerman M R, Abboud H E, Evolving role of growth factors in the renal response to acute and chronic disease. Journal of the American Society of Nephrology : JASN. 1992; 2(7): 1163-70.
Woolf A S, Bosch R J, Fine L G, Growth factors in the pathogenesis of renovascular complications of diabetes mellitus. Journal of hypertension. Supplement : official journal of the International Society of Hypertension. 1992; 10(1): S11-6.
Fine L G, Norman J T, Renal growth responses to acute and chronic injury: routes to therapeutic intervention. Journal of the American Society of Nephrology : JASN. 1992; 2(10 Suppl): S206-11.
Mackovic-Basic M, Fine L G, Norman J T, Cragoe E J, Kurtz I, Stimulation of Na+/H+ exchange is not required for induction of hypertrophy of renal cells in vitro. Journal of the American Society of Nephrology : JASN. 1992; 3(5): 1124-30.
Woolf A S, Fine L G, Do glomerular hemodynamic adaptations influence the progression of human renal disease?. Pediatric nephrology (Berlin, Germany). 1991; 5(1): 88-93.
Rodemann H P, Müller G A, Knecht A, Norman J T, Fine L G, Fibroblasts of rabbit kidney in culture. I. Characterization and identification of cell-specific markers. The American journal of physiology. 1991; 261(2 Pt 2): F283-91.
Knecht A, Fine L G, Kleinman K S, Rodemann H P, Müller G A, Woo D D, Norman J T, Fibroblasts of rabbit kidney in culture. II. Paracrine stimulation of papillary fibroblasts by PDGF. The American journal of physiology. 1991; 261(2 Pt 2): F292-9.
Fine L G, How little kidney tissue is enough?. The New England journal of medicine. 1991; 325(15): 1097-9.
Woolf A S, Hornbruch A, Fine L G, Integration of new embryonic nephrons into the kidney. American journal of kidney diseases : the official journal of the National Kidney Foundation. 1991; 17(6): 611-4.
Fine L G, Introduction. Aberrant cell growth in the genesis of and recovery from renal diseases. American journal of kidney diseases : the official journal of the National Kidney Foundation. 1991; 17(6): 601-2.
Fine L G, Woolf A S, Gallego C, Of rats and men: the need for more convincing clinical studies on progression of renal diseases. American journal of kidney diseases : the official journal of the National Kidney Foundation. 1991; 17(3): 258-60.
Kujubu D A, Norman J T, Herschman H R, Fine L G, Primary response gene expression in renal hypertrophy and hyperplasia: evidence for different growth initiation processes. The American journal of physiology. 1991; 260(6 Pt 2): F823-7.
Fine L G, A proposal to improve the attractiveness of nephrology as a subspecialty choice for residents in internal medicine. American journal of kidney diseases : the official journal of the National Kidney Foundation. 1990; 15(4): 302-4.
Woolf A S, Palmer S J, Snow M L, Fine L G, Creation of a functioning chimeric mammalian kidney. Kidney international. 1990; 38(5): 991-7.
Norman J, Tsau Y K, Bacay A, Fine L G, Epidermal growth factor accelerates functional recovery from ischaemic acute tubular necrosis in the rat: role of the epidermal growth factor receptor. Clinical science (London, England : 1979). 1990; 78(5): 445-50.
Fine L G, Henry Bence Jones (1813-1873): on the influence of diet on urine composition. Including a previously unpublished treatise on the subject and a bibliography of his writings. Kidney international. 1990; 37(3): 1019-25.
Fine L G, Henry Bence Jones (1813-1873): on the influence of diet on urine composition. Including a previously unpublished treatise on the subject and a bibliography of his writings. Kidney international. 1990; 37(3): 1019-25.
Hwang S, Bohman R, Navas P, Norman J T, Bradley T, Fine L G, Hypertrophy of renal mitochondria. Journal of the American Society of Nephrology : JASN. 1990; 1(5): 822-7.
Knecht A, Fine L G, Nutritional factors affecting renal growth and hypertrophy. Seminars in nephrology. 1990; 10(5): 464-71.
Schwieger J, Fine L G, Renal hypertrophy, growth factors, and nephropathy in diabetes mellitus. Seminars in nephrology. 1990; 10(3): 242-53.
Fine L G, Norman J, Cellular events in renal hypertrophy. Annual review of physiology. 1989; 51(1): 19-32.
Bacay A C, Mantyh C R, Cohen A H, Mantyh P W, Fine L G, Glomerular atrial natriuretic factor receptors in primary glomerulopathies: studies on human renal biopsies. American journal of kidney diseases : the official journal of the National Kidney Foundation. 1989; 14(5): 386-95.
Boehmer C G, Norman J, Catton M, Fine L G, Mantyh P W, High levels of mRNA coding for substance P, somatostatin and alpha-tubulin are expressed by rat and rabbit dorsal root ganglia neurons. Peptides. 1989; 10(6): 1179-94.
Bacallao R, Fine L G, Molecular events in the organization of renal tubular epithelium: from nephrogenesis to regeneration. The American journal of physiology. 1989; 257(6 Pt 2): F913-24.
Kujubu D A, Fine L G, Physiology and cell biology update: polypeptide growth factors and their relation to renal disease. American journal of kidney diseases : the official journal of the National Kidney Foundation. 1989; 14(1): 61-73.
Segal R, Fine L G, Polypeptide growth factors and the kidney. Kidney international. Supplement. 1989; 27(5): S2-10.
Norman J T, Bohman R E, Fischmann G, Bowen J W, McDonough A, Slamon D, Fine L G, Patterns of mRNA expression during early cell growth differ in kidney epithelial cells destined to undergo compensatory hypertrophy versus regenerative hyperplasia. Proceedings of the National Academy of Sciences of the United States of America. 1988; 85(18): 6768-72.
Fine L G, Preventing the progression of human renal disease: have rational therapeutic principles emerged?. Kidney international. 1988; 33(1): 116-28.
Kleinman K S, Fine L G, Prognostic implications of renal hypertrophy in diabetes mellitus. Diabetes/metabolism reviews. 1988; 4(2): 179-89.
Norman J, Badie-Dezfooly B, Nord E P, Kurtz I, Schlosser J, Chaudhari A, Fine L G, EGF-induced mitogenesis in proximal tubular cells: potentiation by angiotensin II. The American journal of physiology. 1987; 253(2 Pt 2): F299-309.
Fine L G, The role of nutrition in hypertrophy of renal tissue. Kidney international. Supplement. 1987; 22(1): S2-8.
Fine L G, The uremic syndrome: adaptive mechanisms and therapy. Hospital practice (Office ed.). 1987; 22(9): 63-73.
Nord E P, Goldfarb D, Mikhail N, Moradeshagi P, Hafezi A, Vaystub S, Cragoe E J, Fine L G, Characteristics of the Na+-H+ antiporter in the intact renal proximal tubular cell. The American journal of physiology. 1986; 250(3 Pt 2): F539-50.
Fine L G, Circle of urine glasses: art of uroscopy. American journal of nephrology. 1986; 6(4): 307-11.
Fine L G, Eustachio's discovery of the renal tubule. American journal of nephrology. 1986; 6(1): 47-50.
Fine L G, Pathological specimens of the kidney examined by Richard Bright. Kidney international. 1986; 29(3): 779-83.
Fine L G, Sakhrani L M, Proximal tubular cells in primary culture. Mineral and electrolyte metabolism. 1986; 12(1): 51-7.
Nord E P, Goldfarb D, Fine L G, Regulation of Na+/H+ antiport in the intact renal proximal tubular cell. Advances in experimental medicine and biology. 1986; 208(3): 529-32.
Fine L G, Bradley T, Adaptation of proximal tubular structure and function: insights into compensatory renal hypertrophy. Federation proceedings. 1985; 44(11): 2723-7.
Fine L G, Holley R W, Nasri H, Badie-Dezfooly B, BSC-1 growth inhibitor transforms a mitogenic stimulus into a hypertrophic stimulus for renal proximal tubular cells: relationship to Na+/H+ antiport activity. Proceedings of the National Academy of Sciences of the United States of America. 1985; 82(18): 6163-6.
Salehmoghaddam S, Bradley T, Mikhail N, Badie-Dezfooly B, Nord E P, Trizna W, Kheyfets R, Fine L G, Hypertrophy of basolateral Na-K pump activity in the proximal tubule of the remnant kidney. Laboratory investigation; a journal of technical methods and pathology. 1985; 53(4): 443-52.
Fine L G, Badie-Dezfooly B, Lowe A G, Hamzeh A, Wells J, Salehmoghaddam S, Stimulation of Na+/H+ antiport is an early event in hypertrophy of renal proximal tubular cells. Proceedings of the National Academy of Sciences of the United States of America. 1985; 82(6): 1736-40.
Fine L G, William Bowman's description of the glomerulus. American journal of nephrology. 1985; 5(6): 437-40.
Vigne P, Jean T, Barbry P, Frelin C, Fine L G, Lazdunski M, [3H]Ethylpropylamiloride, a ligand to analyze the properties of the Na+/H+ exchange system in the membranes of normal and hypertrophied kidneys. The Journal of biological chemistry. 1985; 260(26): 14120-5.
Nord E P, Hafezi A, Kaunitz J D, Trizna W, Fine L G, pH gradient-dependent increased Na+-H+ antiport capacity of the rabbit remnant kidney. The American journal of physiology. 1985; 249(1 Pt 2): F90-8.

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