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Steve Horvath, Ph.D., Sc.D. [ Edit Your Profile ]

Work Email Address: shorvath@mednet.ucla.edu

Work Phone Number: (310) 825-9299

Laboratory Address:
Gonda 5545

Mailing Address:
Department of Human Genetics
Gonda Research Center
David Geffen School of Medicine
695 Charles E. Young Drive South
Box 708822
Los Angeles, CA 90095

Work Address:
Gonda 4357A
Campus - 708822
CA Gonda
Los Angeles, CA 90095 Gonda
Los Angeles, CA 90095

Work
UCLA Professor, Biostatistics Professor, Human Genetics

Education:
Degrees:
Sc.D., Harvard School of Public Health, 1995 - 2000
Ph.D., University of Berlin, Germany, 1985 - 1989
B.Sc., University of Berlin, Germany, 1985 - 1989

About

Dr. Steve Horvath is a Professor of Human Genetics and Biostatistics at UCLA with expertise in gene expression, gene networks, gene clinical correlations, and evaluation of biomarkers. He collaborates closely with investigators in the Department of Pathology, Urology and Human Genetics and with CTSI investigators and statisticians in person and through the innovative Biostatistical Teleconference Facility. He collaborates regularly with Dr. Robert Elashoff, a Program Leader for the Biostatistics, Study Design and Clinical Data Management Program (BSD-CDM) and looks forward to the development of a joint genomic research program with Dr. X. Guo, as their methodologies will be jointly informative of many genomic issues. As a faculty member of the Department of Human Genetics, Dr. Horvath has access to the extensive instrumentation available in the department. His research continues to be in the development and application of weighted genes co-expression network analysis. His role on the Biostatistics, Study Design and Clinical Data Management Program (BSD-CDM) will be to develop novel statistical applications and methodologies to address the complexities of biological data and the challenges of community-based research, specifically in High-throughput biological data analysis research.

Publications
Manuyakorn Ananya, Paulus Rebecca, Farrell James, Dawson Nicole A, Tze Sheila, Cheung-Lau Gardenia, Hines Oscar Joe, Reber Howard, Seligson David B, Horvath Steve, Kurdistani Siavash K, Guha Chandhan, Dawson David W, Cellular histone modification patterns predict prognosis and treatment response in resectable pancreatic adenocarcinoma: results from RTOG 9704. Journal of clinical oncology : official journal of the American Society of Clinical Oncology. 2010; 28(8): 1358-65.
Mumford Jeanette A, Horvath Steve, Oldham Michael C, Langfelder Peter, Geschwind Daniel H, Poldrack Russell A, Detecting network modules in fMRI time series: a weighted network analysis approach. NeuroImage. 2010; 52(4): 1465-76.
Miller Jeremy A, Horvath Steve, Geschwind Daniel H, Divergence of human and mouse brain transcriptome highlights Alzheimer disease pathways. Proceedings of the National Academy of Sciences of the United States of America. 2010; 107(28): 12698-703.
Yoon Nam K, Maresh Erin L, Elshimali Yahya, Li Ai, Horvath Steve, Seligson David B, Chia David, Goodglick Lee, Elevated MED28 expression predicts poor outcome in women with breast cancer. BMC cancer. 2010; 10(28): 335.
Habeeb Omar, Goodglick Lee, Soslow Robert A, Rao Rajiv G, Gordon Lynn K, Schirripa Osvaldo, Horvath Steve, Braun Jonathan, Seligson David B, Wadehra Madhuri, Epithelial membrane protein-2 expression is an early predictor of endometrial cancer development. Cancer. 2010; 116(20): 4718-26.
de Jong Simone, Fuller Tova F, Janson Esther, Strengman Eric, Horvath Steve, Kas Martien J H, Ophoff Roel A, Gene expression profiling in C57BL/6J and A/J mouse inbred strains reveals gene networks specific for brain regions independent of genetic background. BMC genomics. 2010; 11(8): 20.
Le Brandon H, Cheng Chen, Bui Anhthu Q, Wagmaister Javier A, Henry Kelli F, Pelletier Julie, Kwong Linda, Belmonte Mark, Kirkbride Ryan, Horvath Steve, Drews Gary N, Fischer Robert L, Okamuro Jack K, Harada John J, Goldberg Robert B, Global analysis of gene activity during Arabidopsis seed development and identification of seed-specific transcription factors. Proceedings of the National Academy of Sciences of the United States of America. 2010; 107(18): 8063-70.
Yoon Nam K, Maresh Erin L, Shen Dejun, Elshimali Yahya, Apple Sophia, Horvath Steve, Mah Vei, Bose Shikha, Chia David, Chang Helena R, Goodglick Lee, Higher levels of GATA3 predict better survival in women with breast cancer. Human pathology. 2010; 41(12): 1794-801.
Cai Chaochao, Langfelder Peter, Fuller Tova F, Oldham Michael C, Luo Rui, van den Berg Leonard H, Ophoff Roel A, Horvath Steve, Is human blood a good surrogate for brain tissue in transcriptional studies?. BMC genomics. 2010; 11(12): 589.
Ooi Aik T, Mah Vei, Nickerson Derek W, Gilbert Jennifer L, Ha Vi Luan, Hegab Ahmed E, Horvath Steve, Alavi Mohammad, Maresh Erin L, Chia David, Gower Adam C, Lenburg Marc E, Spira Avrum, Solis Luisa M, Wistuba Ignacio I, Walser Tonya C, Wallace William D, Dubinett Steven M, Goodglick Lee, Gomperts Brigitte N, Presence of a putative tumor-initiating progenitor cell population predicts poor prognosis in smokers with non-small cell lung cancer. Cancer research. 2010; 70(16): 6639-48.
Plaisier Christopher L, Horvath Steve, Huertas-Vazquez Adriana, Cruz-Bautista Ivette, Herrera Miguel F, Tusie-Luna Teresa, Aguilar-Salinas Carlos, Pajukanta Päivi, A systems genetics approach implicates USF1, FADS3, and other causal candidate genes for familial combined hyperlipidemia. PLoS genetics. 2009; 5(9): e1000642.
Farber Charles R, van Nas Atila, Ghazalpour Anatole, Aten Jason E, Doss Sudheer, Sos Brandon, Schadt Eric E, Ingram-Drake Leslie, Davis Richard C, Horvath Steve, Smith Desmond J, Drake Thomas A, Lusis Aldons J, An integrative genetics approach to identify candidate genes regulating BMD: combining linkage, gene expression, and association. Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research. 2009; 24(1): 105-16.
Kurian Sunil M, Heilman Raymond, Mondala Tony S, Nakorchevsky Aleksey, Hewel Johannes A, Campbell Daniel, Robison Elizabeth H, Wang Lin, Lin Wen, Gaber Lillian, Solez Kim, Shidban Hamid, Mendez Robert, Schaffer Randolph L, Fisher Jonathan S, Flechner Stuart M, Head Steve R, Horvath Steve, Yates John R, Marsh Christopher L, Salomon Daniel R, Biomarkers for early and late stage chronic allograft nephropathy by proteogenomic profiling of peripheral blood. PloS one. 2009; 4(7): e6212.
Kleefuss-Lie Ailing, Friedl Waltraut, Cichon Sven, Haug Karsten, Warnstedt Maike, Alekov Alexi, Sander Thomas, Ramirez Alfredo, Poser Barbara, Maljevic Snezana, Hebeisen Simon, Kubisch Christian, Rebstock Johannes, Horvath Steve, Hallmann Kerstin, Dullinger Jörn S, Rau Birgit, Haverkamp Fritz, Beyenburg Stefan, Schulz Herbert, Janz Dieter, Giese Bernd, Müller-Newen Gerhard, Propping Peter, Elger Christian E, Fahlke Christoph, Lerche Holger, CLCN2 variants in idiopathic generalized epilepsy. Nature genetics. 2009; 41(9): 954-5.
Guo Deliang, Prins Robert M, Dang Julie, Kuga Daisuke, Iwanami Akio, Soto Horacio, Lin Kelly Y, Huang Tiffany T, Akhavan David, Hock M Benjamin, Zhu Shaojun, Kofman Ava A, Bensinger Steve J, Yong William H, Vinters Harry V, Horvath Steve, Watson Andrew D, Kuhn John G, Robins H Ian, Mehta Minesh P, Wen Patrick Y, DeAngelis Lisa M, Prados Michael D, Mellinghoff Ingo K, Cloughesy Timothy F, Mischel Paul S, EGFR signaling through an Akt-SREBP-1-dependent, rapamycin-resistant pathway sensitizes glioblastomas to antilipogenic therapy. Science signaling. 2009; 2(101): ra82.
van Nas Atila, Guhathakurta Debraj, Wang Susanna S, Yehya Nadir, Horvath Steve, Zhang Bin, Ingram-Drake Leslie, Chaudhuri Gautam, Schadt Eric E, Drake Thomas A, Arnold Arthur P, Lusis Aldons J, Elucidating the role of gonadal hormones in sexually dimorphic gene coexpression networks. Endocrinology. 2009; 150(3): 1235-49.
Farber Charles R, Aten Jason E, Farber Emily A, de Vera Vincent, Gularte Rodrigo, Islas-Trejo Alma, Wen Pengzi, Horvath Steve, Lucero Michael, Lusis Aldons J, Medrano Juan F, Genetic dissection of a major mouse obesity QTL (Carfhg2): integration of gene expression and causality modeling. Physiological genomics. 2009; 37(3): 294-302.
Seligson David B, Horvath Steve, McBrian Matthew A, Mah Vei, Yu Hong, Tze Sheila, Wang Qun, Chia David, Goodglick Lee, Kurdistani Siavash K, Global levels of histone modifications predict prognosis in different cancers. The American journal of pathology. 2009; 174(5): 1619-28.
Yoon Nam K, Seligson David B, Chia David, Elshimali Yahya, Sulur Giri, Li Ai, Horvath Steve, Maresh Erin, Mah Vei, Bose Shikha, Bonavida Benjamin, Goodglick Lee, Higher expression levels of 14-3-3sigma in ductal carcinoma in situ of the breast predict poorer outcome. Cancer biomarkers : section A of Disease markers. 2009; 5(4): 215-24.
Laks Dan R, Masterman-Smith Michael, Visnyei Koppany, Angenieux Brigitte, Orozco Nicholas M, Foran Ian, Yong William H, Vinters Harry V, Liau Linda M, Lazareff Jorge A, Mischel Paul S, Cloughesy Timothy F, Horvath Steve, Kornblum Harley I, Neurosphere formation is an independent predictor of clinical outcome in malignant glioma. Stem cells (Dayton, Ohio). 2009; 27(4): 980-7.
Haug Karsten, Warnstedt Maike, Alekov Alexi K, Sander Thomas, Ramírez Alfredo, Poser Barbara, Maljevic Snezana, Hebeisen Simon, Kubisch Christian, Rebstock Johannes, Horvath Steve, Hallmann Kerstin, Dullinger Joern S, Rau Birgit, Haverkamp Fritz, Beyenburg Stefan, Schulz Herbert, Janz Dieter, Giese Bernd, Müller-Newen Gerhard, Propping Peter, Elger Christian E, Fahlke Christoph, Lerche Holger, Retraction: Mutations in CLCN2 encoding a voltage-gated chloride channel are associated with idiopathic generalized epilepsies. Nature genetics. 2009; 41(9): 1043.
Sridharan Rupa, Tchieu Jason, Mason Mike J, Yachechko Robin, Kuoy Edward, Horvath Steve, Zhou Qing, Plath Kathrin, Role of the murine reprogramming factors in the induction of pluripotency. Cell. 2009; 136(2): 364-77.
Mason Mike J, Fan Guoping, Plath Kathrin, Zhou Qing, Horvath Steve, Signed weighted gene co-expression network analysis of transcriptional regulation in murine embryonic stem cells. BMC genomics. 2009; 10(9): 327.
Hu Shen, Zhou Michael, Jiang Jiang, Wang Jianghua, Elashoff David, Gorr Sven, Michie Sara A, Spijkervet Fred K L, Bootsma Hendrika, Kallenberg Cees G M, Vissink Arjan, Horvath Steve, Wong David T, Systems biology analysis of Sjögren's syndrome and mucosa-associated lymphoid tissue lymphoma in parotid glands. Arthritis and rheumatism. 2009; 60(1): 81-92.
Winden Kellen D, Oldham Michael C, Mirnics Karoly, Ebert Philip J, Swan Christo H, Levitt Pat, Rubenstein John L, Horvath Steve, Geschwind Daniel H, The organization of the transcriptional network in specific neuronal classes. Molecular systems biology. 2009; 5(1): 291.
MacLennan Nicole K, Dong Jun, Aten Jason E, Horvath Steve, Rahib Lola, Ornelas Loren, Dipple Katrina M, McCabe Edward R B, Weighted gene co-expression network analysis identifies biomarkers in glycerol kinase deficient mice. Molecular genetics and metabolism. 2009; 98(1-2): 203-14.
Saris Christiaan G J, Horvath Steve, van Vught Paul W J, van Es Michael A, Blauw Hylke M, Fuller Tova F, Langfelder Peter, DeYoung Joseph, Wokke John H J, Veldink Jan H, van den Berg Leonard H, Ophoff Roel A, Weighted gene co-expression network analysis of the peripheral blood from Amyotrophic Lateral Sclerosis patients. BMC genomics. 2009; 10(9): 405.
Cloughesy Tim F, Yoshimoto Koji, Nghiemphu Phioanh, Brown Kevin, Dang Julie, Zhu Shaojun, Hsueh Teli, Chen Yinan, Wang Wei, Youngkin David, Liau Linda, Martin Neil, Becker Don, Bergsneider Marvin, Lai Albert, Green Richard, Oglesby Tom, Koleto Michael, Trent Jeff, Horvath Steve, Mischel Paul S, Mellinghoff Ingo K, Sawyers Charles L, Antitumor activity of rapamycin in a Phase I trial for patients with recurrent PTEN-deficient glioblastoma. PLoS medicine. 2008; 5(1): e8.
Langfelder Peter, Zhang Bin, Horvath Steve, Defining clusters from a hierarchical cluster tree: the Dynamic Tree Cut package for R. Bioinformatics (Oxford, England). 2008; 24(5): 719-20.
Yoshimoto Koji, Dang Julie, Zhu Shaojun, Nathanson David, Huang Tiffany, Dumont Rebecca, Seligson David B, Yong William H, Xiong Zhenggang, Rao Nagesh, Winther Henrik, Chakravarti Arnab, Bigner Darell D, Mellinghoff Ingo K, Horvath Steve, Cavenee Webster K, Cloughesy Timothy F, Mischel Paul S, Development of a real-time RT-PCR assay for detecting EGFRvIII in glioblastoma samples. Clinical cancer research : an official journal of the American Association for Cancer Research. 2008; 14(2): 488-93.
Oldham Michael C, Konopka Genevieve, Iwamoto Kazuya, Langfelder Peter, Kato Tadafumi, Horvath Steve, Geschwind Daniel H, Functional organization of the transcriptome in human brain. Nature neuroscience. 2008; 11(11): 1271-82.
Lee Yohan, Scheck Adrienne C, Cloughesy Timothy F, Lai Albert, Dong Jun, Farooqi Haumith K, Liau Linda M, Horvath Steve, Mischel Paul S, Nelson Stanley F, Gene expression analysis of glioblastomas identifies the major molecular basis for the prognostic benefit of younger age. BMC medical genomics. 2008; 1(11): 52.
Horvath Steve, Dong Jun, Geometric interpretation of gene coexpression network analysis. PLoS computational biology. 2008; 4(8): e1000117.
Presson Angela P, Sobel Eric M, Papp Jeanette C, Suarez Charlyn J, Whistler Toni, Rajeevan Mangalathu S, Vernon Suzanne D, Horvath Steve, Integrated weighted gene co-expression network analysis with an application to chronic fatigue syndrome. BMC systems biology. 2008; 2(1): 95.
Nakano Ichiro, Masterman-Smith Michael, Saigusa Kuniyasu, Paucar Andres A, Horvath Steve, Shoemaker Lorelei, Watanabe Momoko, Negro Alejandra, Bajpai Ruchi, Howes Amy, Lelievre Vincent, Waschek James A, Lazareff Jorge A, Freije William A, Liau Linda M, Gilbertson Richard J, Cloughesy Timothy F, Geschwind Daniel H, Nelson Stanley F, Mischel Paul S, Terskikh Alexey V, Kornblum Harley I, Maternal embryonic leucine zipper kinase is a key regulator of the proliferation of malignant brain tumors, including brain tumor stem cells. Journal of neuroscience research. 2008; 86(1): 48-60.
Seligson David B, Rajasekaran Sigrid A, Yu Hong, Liu Xueli, Eeva Mervi, Tze Sheila, Ball William, Horvath Steve, deKernion Jean B, Rajasekaran Ayyappan K, Na,K-adenosine triphosphatase alpha1-subunit predicts survival of renal clear cell carcinoma. The Journal of urology. 2008; 179(1): 338-45.
Aten Jason E, Fuller Tova F, Lusis Aldons J, Horvath Steve, Using genetic markers to orient the edges in quantitative trait networks: the NEO software. BMC systems biology. 2008; 2(8): 34.
Chen Yanqing, Zhu Jun, Lum Pek Yee, Yang Xia, Pinto Shirly, MacNeil Douglas J, Zhang Chunsheng, Lamb John, Edwards Stephen, Sieberts Solveig K, Leonardson Amy, Castellini Lawrence W, Wang Susanna, Champy Marie-France, Zhang Bin, Emilsson Valur, Doss Sudheer, Ghazalpour Anatole, Horvath Steve, Drake Thomas A, Lusis Aldons J, Schadt Eric E, Variations in DNA elucidate molecular networks that cause disease. Nature. 2008; 452(7186): 429-35.
Langfelder Peter, Horvath Steve, WGCNA: an R package for weighted correlation network analysis. BMC bioinformatics. 2008; 9(1): 559.
Gong Ke Wei, Zhao Wei, Li Ning, Barajas Berenice, Kleinman Michael, Sioutas Constantinos, Horvath Steve, Lusis Aldons J, Nel Andre, Araujo Jesus A, Air-pollutant chemicals and oxidized lipids exhibit genome-wide synergistic effects on endothelial cells. Genome biology. 2007; 8(7): R149.
Abba Martín C, Sun Hongxia, Hawkins Kathleen A, Drake Jeffrey A, Hu Yuhui, Nunez Maria I, Gaddis Sally, Shi Tao, Horvath Steve, Sahin Aysegul, Aldaz C Marcelo, Breast cancer molecular signatures as determined by SAGE: correlation with lymph node status. Molecular cancer research : MCR. 2007; 5(9): 881-90.
Langfelder Peter, Horvath Steve, Eigengene networks for studying the relationships between co-expression modules. BMC systems biology. 2007; 1(1): 54.
Seligson David B, Hongo Fumiya, Huerta-Yepez Sara, Mizutani Yoichi, Miki Tsuneharu, Yu Hong, Horvath Steve, Chia David, Goodglick Lee, Bonavida Benjamin, Expression of X-linked inhibitor of apoptosis protein is a strong predictor of human prostate cancer recurrence. Clinical cancer research : an official journal of the American Association for Cancer Research. 2007; 13(20): 6056-63.
Yip Andy M, Horvath Steve, Gene network interconnectedness and the generalized topological overlap measure. BMC bioinformatics. 2007; 8(1-2): 22.
Rahib Lola, MacLennan Nicole K, Horvath Steve, Liao James C, Dipple Katrina M, Glycerol kinase deficiency alters expression of genes involved in lipid metabolism, carbohydrate metabolism, and insulin signaling. European journal of human genetics : EJHG. 2007; 15(6): 646-57.
Li Ai, Horvath Steve, Network neighborhood analysis with the multi-node topological overlap measure. Bioinformatics (Oxford, England). 2007; 23(2): 222-31.
Carlson Marc R J, Pope Whitney B, Horvath Steve, Braunstein Jerome G, Nghiemphu Phioanh, Tso Cho-Lea, Mellinghoff Ingo, Lai Albert, Liau Linda M, Mischel Paul S, Dong Jun, Nelson Stanley F, Cloughesy Timothy F, Relationship between survival and edema in malignant gliomas: role of vascular endothelial growth factor and neuronal pentraxin 2. Clinical cancer research : an official journal of the American Association for Cancer Research. 2007; 13(9): 2592-8.
Eller C Daniel, Regelson Moira, Merriman Barry, Nelson Stan, Horvath Steve, Marahrens York, Repetitive sequence environment distinguishes housekeeping genes. Gene. 2007; 390(1-2): 153-65.
Dong Jun, Horvath Steve, Understanding network concepts in modules. BMC systems biology. 2007; 1(6-7): 24.
Fuller Tova F, Ghazalpour Anatole, Aten Jason E, Drake Thomas A, Lusis Aldons J, Horvath Steve, Weighted gene coexpression network analysis strategies applied to mouse weight. Mammalian genome : official journal of the International Mammalian Genome Society. 2007; 18(6-7): 463-72.
Oldham Michael C, Horvath Steve, Geschwind Daniel H, Conservation and evolution of gene coexpression networks in human and chimpanzee brains. Proceedings of the National Academy of Sciences of the United States of America. 2006; 103(47): 17973-8.
Mitchell Scherise, Ota Asuka, Foster William, Zhang Bin, Fang Zixing, Patel Shilpa, Nelson Stanley F, Horvath Steve, Wang Yibin, Distinct gene expression profiles in adult mouse heart following targeted MAP kinase activation. Physiological genomics. 2006; 25(1): 50-9.
Bocklandt Sven, Horvath Steve, Vilain Eric, Hamer Dean H, Extreme skewing of X chromosome inactivation in mothers of homosexual men. Human genetics. 2006; 118(6): 691-4.
Lam John S, Seligson David B, Yu Hong, Li Ai, Eeva Mervi, Pantuck Allan J, Zeng Gang, Horvath Steve, Belldegrun Arie S, Flap endonuclease 1 is overexpressed in prostate cancer and is associated with a high Gleason score. BJU international. 2006; 98(2): 445-51.
Carlson Marc R J, Zhang Bin, Fang Zixing, Mischel Paul S, Horvath Steve, Nelson Stanley F, Gene connectivity, function, and sequence conservation: predictions from modular yeast co-expression networks. BMC genomics. 2006; 7(1): 40.
Gargalovic Peter S, Imura Minori, Zhang Bin, Gharavi Nima M, Clark Michael J, Pagnon Joanne, Yang Wen-Pin, He Aiqing, Truong Amy, Patel Shilpa, Nelson Stanley F, Horvath Steve, Berliner Judith A, Kirchgessner Todd G, Lusis Aldons J, Identification of inflammatory gene modules based on variations of human endothelial cell responses to oxidized lipids. Proceedings of the National Academy of Sciences of the United States of America. 2006; 103(34): 12741-6.
Ghazalpour Anatole, Doss Sudheer, Zhang Bin, Wang Susanna, Plaisier Christopher, Castellanos Ruth, Brozell Alec, Schadt Eric E, Drake Thomas A, Lusis Aldons J, Horvath Steve, Integrating genetic and network analysis to characterize genes related to mouse weight. PLoS genetics. 2006; 2(8): e130.
MacLennan Nicole K, Rahib Lola, Shin Cynthia, Fang Zixing, Horvath Steve, Dean Jason, Liao James C, McCabe Edward R B, Dipple Katrina M, Targeted disruption of glycerol kinase gene in mice: expression analysis in liver shows alterations in network partners related to glycerol kinase activity. Human molecular genetics. 2006; 15(3): 405-15.
Zhang Bin, Horvath Steve, A general framework for weighted gene co-expression network analysis. Statistical applications in genetics and molecular biology. 2005; 4(3): Article17.
Lam John S, Shvarts Oleg, Said Jonathan W, Pantuck Allan J, Seligson David B, Aldridge Michael E, Bui Matthew H T, Liu Xueli, Horvath Steve, Figlin Robert A, Belldegrun Arie S, Clinicopathologic and molecular correlations of necrosis in the primary tumor of patients with renal cell carcinoma. Cancer. 2005; 103(12): 2517-25.
Seligson David, Horvath Steve, Huerta-Yepez Sara, Hanna Stephanie, Garban Hermes, Roberts Alice, Shi Tao, Liu Xueli, Chia David, Goodglick Lee, Bonavida Benjamin, Expression of transcription factor Yin Yang 1 in prostate cancer. International journal of oncology. 2005; 27(1): 131-41.
Seligson David B, Horvath Steve, Shi Tao, Yu Hong, Tze Sheila, Grunstein Michael, Kurdistani Siavash K, Global histone modification patterns predict risk of prostate cancer recurrence. Nature. 2005; 435(7046): 1262-6.
Ouyang Yan, Salstrom Jennifer, Diaz-Perez Silvia, Nahas Shareef, Matsuno Youko, Dawson David, Teitell Michael A, Horvath Steve, Riggs Arthur D, Gatti Richard A, Marahrens York, Inhibition of Atm and/or Atr disrupts gene silencing on the inactive X chromosome. Biochemical and biophysical research communications. 2005; 337(3): 875-80.
Mellinghoff Ingo K, Wang Maria Y, Vivanco Igor, Haas-Kogan Daphne A, Zhu Shaojun, Dia Ederlyn Q, Lu Kan V, Yoshimoto Koji, Huang Julie H Y, Chute Dennis J, Riggs Bridget L, Horvath Steve, Liau Linda M, Cavenee Webster K, Rao P Nagesh, Beroukhim Rameen, Peck Timothy C, Lee Jeffrey C, Sellers William R, Stokoe David, Prados Michael, Cloughesy Timothy F, Sawyers Charles L, Mischel Paul S, Molecular determinants of the response of glioblastomas to EGFR kinase inhibitors. The New England journal of medicine. 2005; 353(19): 2012-24.
Lam John S, Yamashiro Joyce, Shintaku I Peter, Vessella Robert L, Jenkins Robert B, Horvath Steve, Said Jonathan W, Reiter Robert E, Prostate stem cell antigen is overexpressed in prostate cancer metastases. Clinical cancer research : an official journal of the American Association for Cancer Research. 2005; 11(7): 2591-6.
Zhang Bin, Horvath Steve, Ridge regression based hybrid genetic algorithms for multi-locus quantitative trait mapping. International journal of bioinformatics research and applications. 2005; 1(3): 261-72.
Shi Tao, Seligson David, Belldegrun Arie S, Palotie Aarno, Horvath Steve, Tumor classification by tissue microarray profiling: random forest clustering applied to renal cell carcinoma. Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc. 2005; 18(4): 547-57.
Kim Hyung L, Seligson David, Liu Xueli, Janzen Nicolette, Bui Matthew H T, Yu Hong, Shi Tao, Belldegrun Arie S, Horvath Steve, Figlin Robert A, Using tumor markers to predict the survival of patients with metastatic renal cell carcinoma. The Journal of urology. 2005; 173(5): 1496-501.
Shvarts Oleg, Seligson David, Lam John, Shi Tao, Horvath Steve, Figlin Robert, Belldegrun Arie, Pantuck Allan J, p53 is an independent predictor of tumor recurrence and progression after nephrectomy in patients with localized renal cell carcinoma. The Journal of urology. 2005; 173(3): 725-8.
Thomas George V, Horvath Steve, Smith Bradley L, Crosby Katherine, Lebel Lori A, Schrage Matthew, Said Jonathan, De Kernion Jean, Reiter Robert E, Sawyers Charles L, Antibody-based profiling of the phosphoinositide 3-kinase pathway in clinical prostate cancer. Clinical cancer research : an official journal of the American Association for Cancer Research. 2004; 10(24): 8351-6.
Horvath Steve, Xu Xin, Lake Stephen L, Silverman Edwin K, Weiss Scott T, Laird Nan M, Family-based tests for associating haplotypes with general phenotype data: application to asthma genetics. Genetic epidemiology. 2004; 26(1): 61-9.
Zhang Bin, Horvath Steve, Finding the best ridge regression subset by genetic algorithms: applications to multilocus quantitative trait mapping. Conference proceedings : ... Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Conference. 2004; 4(3): 2793-6.
Freije William A, Castro-Vargas F Edmundo, Fang Zixing, Horvath Steve, Cloughesy Timothy, Liau Linda M, Mischel Paul S, Nelson Stanley F, Gene expression profiling of gliomas strongly predicts survival. Cancer research. 2004; 64(18): 6503-10.
Flechner Stuart M, Kurian Sunil M, Head Steven R, Sharp Starlette M, Whisenant Thomas C, Zhang Jie, Chismar Jeffrey D, Horvath Steve, Mondala Tony, Gilmartin Timothy, Cook Daniel J, Kay Steven A, Walker John R, Salomon Daniel R, Kidney transplant rejection and tissue injury by gene profiling of biopsies and peripheral blood lymphocytes. American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons. 2004; 4(9): 1475-89.
Bui Matthew H T, Visapaa Harri, Seligson David, Kim Hyung, Han Ken-Ryu, Huang Yunda, Horvath Steve, Stanbridge Eric J, Palotie Aarno, Figlin Robert A, Belldegrun Arie S, Prognostic value of carbonic anhydrase IX and KI67 as predictors of survival for renal clear cell carcinoma. The Journal of urology. 2004; 171(6 Pt 1): 2461-6.
Han Ken-Ryu, Seligson David B, Liu Xueli, Horvath Steve, Shintaku Peter I, Thomas George V, Said Jonathan W, Reiter Robert E, Prostate stem cell antigen expression is associated with gleason score, seminal vesicle invasion and capsular invasion in prostate cancer. The Journal of urology. 2004; 171(3): 1117-21.
Liu Xueli, Minin Vladimir, Huang Yunda, Seligson David B, Horvath Steve, Statistical methods for analyzing tissue microarray data. Journal of biopharmaceutical statistics. 2004; 14(3): 671-85.
Garraway Isla P, Seligson David, Said Jonathan, Horvath Steve, Reiter Robert E, Trefoil factor 3 is overexpressed in human prostate cancer. The Prostate. 2004; 61(3): 209-14.
Kim Hyung L, Seligson David, Liu Xueli, Janzen Nicolette, Bui Matthew H T, Yu Hong, Shi Tao, Figlin Robert A, Horvath Steve, Belldegrun Arie S, Using protein expressions to predict survival in clear cell renal carcinoma. Clinical cancer research : an official journal of the American Association for Cancer Research. 2004; 10(16): 5464-71.
Kraft Peter, Schadt Eric, Aten Jason, Horvath Steve, A family-based test for correlation between gene expression and trait values. American journal of human genetics. 2003; 72(5): 1323-30.
Espineda Cromwell, Seligson David B, James Ball William, Rao JianYu, Palotie Aarno, Horvath Steve, Huang Yunda, Shi Tao, Rajasekaran Ayyappan K, Analysis of the Na,K-ATPase alpha- and beta-subunit expression profiles of bladder cancer using tissue microarrays. Cancer. 2003; 97(8): 1859-68.
Choe Gheeyoung, Horvath Steve, Cloughesy Timothy F, Crosby Katherine, Seligson David, Palotie Aarno, Inge Landon, Smith Bradley L, Sawyers Charles L, Mischel Paul S, Analysis of the phosphatidylinositol 3'-kinase signaling pathway in glioblastoma patients in vivo. Cancer research. 2003; 63(11): 2742-6.
Bui Matthew H T, Seligson David, Han Ken-ryu, Pantuck Allan J, Dorey Frederick J, Huang Yunda, Horvath Steve, Leibovich Bradley C, Chopra Shefali, Liao Shu-Yuan, Stanbridge Eric, Lerman Michael I, Palotie Aarno, Figlin Robert A, Belldegrun Arie S, Carbonic anhydrase IX is an independent predictor of survival in advanced renal clear cell carcinoma: implications for prognosis and therapy. Clinical cancer research : an official journal of the American Association for Cancer Research. 2003; 9(2): 802-11.
Visapää Harri, Bui Matthew, Huang Yunda, Seligson David, Tsai Henry, Pantuck Allan, Figlin Robert, Rao Jian Y u, Belldegrun Arie, Horvath Steve, Palotie Aarno, Correlation of Ki-67 and gelsolin expression to clinical outcome in renal clear cell carcinoma. Urology. 2003; 61(4): 845-50.
Shai Ruty, Shi Tao, Kremen Thomas J, Horvath Steve, Liau Linda M, Cloughesy Timothy F, Mischel Paul S, Nelson Stanley F, Gene expression profiling identifies molecular subtypes of gliomas. Oncogene. 2003; 22(31): 4918-23.
Allen Elena, Horvath Steve, Tong Frances, Kraft Peter, Spiteri Elizabeth, Riggs Arthur D, Marahrens York, High concentrations of long interspersed nuclear element sequence distinguish monoallelically expressed genes. Proceedings of the National Academy of Sciences of the United States of America. 2003; 100(17): 9940-5.
Mischel Paul S, Shai Ruty, Shi Tao, Horvath Steve, Lu Kan V, Choe Gheeyoung, Seligson David, Kremen Thomas J, Palotie Aarno, Liau Linda M, Cloughesy Timothy F, Nelson Stanley F, Identification of molecular subtypes of glioblastoma by gene expression profiling. Oncogene. 2003; 22(15): 2361-73.
Visapää Harri, Seligson David, Huang Yunda, Rao Jian Yu, Belldegrun Arie, Horvath Steve, Palotie Aarno, Ki67, gelsolin and PTEN expression in sarcomatoid renal tumors. Urological research. 2003; 30(6): 387-9.
Freedland Stephen J, Seligson David B, Liu Alvin Y, Pantuck Allan J, Paik Sun H, Horvath Steve, Wieder Jeffrey A, Zisman Amnon, Nguyen David, Tso Cho-Lea, Palotie Aarno V, Belldegrun Arie S, Loss of CD10 (neutral endopeptidase) is a frequent and early event in human prostate cancer. The Prostate. 2003; 55(1): 71-80.
Kraft Peter, Bauman Lara, Yuan Jin Ying, Horvath Steve, Horvath Steve, Multivariate variance-components analysis of longitudinal blood pressure measurements from the Framingham Heart Study. BMC genetics. 2003; 4 Suppl 1(1): S55.
Haug Karsten, Warnstedt Maike, Alekov Alexi K, Sander Thomas, Ramírez Alfredo, Poser Barbara, Maljevic Snezana, Hebeisen Simon, Kubisch Christian, Rebstock Johannes, Horvath Steve, Hallmann Kerstin, Dullinger Joern S, Rau Birgit, Haverkamp Fritz, Beyenburg Stefan, Schulz Herbert, Janz Dieter, Giese Bernd, Müller-Newen Gerhard, Propping Peter, Elger Christian E, Fahlke Christoph, Lerche Holger, Heils Armin, Mutations in CLCN2 encoding a voltage-gated chloride channel are associated with idiopathic generalized epilepsies. Nature genetics. 2003; 33(4): 527-32.
Tilgen Nikola, Rebstock Johannes, Horvath Steve, Propping Peter, Elger Christian Erich, Heils Armin, Prodynorphin gene promoter polymorphism and temporal lobe epilepsy. Annals of neurology. 2003; 53(2): 280-1; author reply 281-2.
Dewing Phoebe, Shi Tao, Horvath Steve, Vilain Eric, Sexually dimorphic gene expression in mouse brain precedes gonadal differentiation. Brain research. Molecular brain research. 2003; 118(1-2): 82-90.
Kraft Peter, Horvath Steve, The genetics of gene expression and gene mapping. Trends in biotechnology. 2003; 21(9): 377-8.
Tilgen Nikola, Pfeiffer Heike, Cobilanschi Joana, Rau Birgit, Horvath Steve, Elger Christian E, Propping Peter, Heils Armin, Association analysis between the human interleukin 1beta (-511) gene polymorphism and susceptibility to febrile convulsions. Neuroscience letters. 2002; 334(1): 68-70.
Ide Hisamitsu, Seligson David B, Memarzadeh Sanaz, Xin Li, Horvath Steve, Dubey Purnima, Flick Maryann B, Kacinski Barry M, Palotie Aarno, Witte Owen N, Expression of colony-stimulating factor 1 receptor during prostate development and prostate cancer progression. Proceedings of the National Academy of Sciences of the United States of America. 2002; 99(22): 14404-9.
Rao JianYu, Seligson David, Visapaa Harri, Horvath Steve, Eeva Mervi, Michel Kia, Pantuck Allan, Belldegrun Arie, Palotie Aarno, Tissue microarray analysis of cytoskeletal actin-associated biomarkers gelsolin and E-cadherin in urothelial carcinoma. Cancer. 2002; 95(6): 1247-57.
Maresh Erin L, Mah Vei, Alavi Mohammad, Horvath Steve, Bagryanova Lora, Liebeskind Emily S, Knutzen Laura A, Zhou Yong, Chia David, Liu Alvin Y, Goodglick Lee, Differential expression of anterior gradient gene AGR2 in prostate cancer. BMC cancer. 2010; 10(6): 680.
Mah Vei, Marquez Diana, Alavi Mohammad, Maresh Erin L, Zhang Li, Yoon Nam, Horvath Steve, Bagryanova Lora, Fishbein Michael C, Chia David, Pietras Richard, Goodglick Lee, Expression levels of estrogen receptor beta in conjunction with aromatase predict survival in non-small cell lung cancer. Lung cancer (Amsterdam, Netherlands). 2011; 474(7351): .
Park Christopher C, Gale Greg D, de Jong Simone, Ghazalpour Anatole, Bennett Brian J, Farber Charles R, Langfelder Peter, Lin Andy, Khan Arshad H, Eskin Eleazar, Horvath Steve, Lusis Aldons J, Ophoff Roel A, Smith Desmond J, Gene networks associated with conditional fear in mice identified using a systems genetics approach. BMC systems biology. 2011; 5(7351): 43.
Presson Angela P, Yoon Nam K, Bagryanova Lora, Mah Vei, Alavi Mohammad, Maresh Erin L, Rajasekaran Ayyappan K, Goodglick Lee, Chia David, Horvath Steve, Protein expression based multimarker analysis of breast cancer samples. BMC cancer. 2011; 11(9): 230.
Voineagu Irina, Wang Xinchen, Johnston Patrick, Lowe Jennifer K, Tian Yuan, Horvath Steve, Mill Jonathan, Cantor Rita M, Blencowe Benjamin J, Geschwind Daniel H, Transcriptomic analysis of autistic brain reveals convergent molecular pathology. Nature. 2011; 474(7351): 380-4.
Langfelder Peter, Castellani Lawrence W, Zhou Zhiqiang, Paul Eric, Davis Richard, Schadt Eric E, Lusis Aldons J, Horvath Steve, Mehrabian Margarete, A systems genetic analysis of high density lipoprotein metabolism and network preservation across mouse models. Biochimica et biophysica acta. 2011; 76(9): .
Huynh Thu P, Mah Vei, Sampson Valerie B, Chia David, Fishbein Michael C, Horvath Steve, Alavi Mohammad, Wu Debbie C, Harper Jeffrey, Sarafian Ted, Dubinett Steven M, Langhans Sigrid A, Goodglick Lee, Rajasekaran Ayyappan K, Na,K-ATPase is a target of cigarette smoke and reduced expression predicts poor patient outcome of smokers with lung cancer. American journal of physiology. Lung cellular and molecular physiology. 2012; 302(11): L1150-8.
Vivanco Igor, Robins H Ian, Rohle Daniel, Campos Carl, Grommes Christian, Nghiemphu Phioanh Leia, Kubek Sara, Oldrini Barbara, Chheda Milan G, Yannuzzi Nicolas, Tao Hui, Zhu Shaojun, Iwanami Akio, Kuga Daisuke, Dang Julie, Pedraza Alicia, Brennan Cameron W, Heguy Adriana, Liau Linda M, Lieberman Frank, Yung W K Alfred, Gilbert Mark R, Reardon David A, Drappatz Jan, Wen Patrick Y, Lamborn Kathleen R, Chang Susan M, Prados Michael D, Fine Howard A, Horvath Steve, Wu Nian, Lassman Andrew B, DeAngelis Lisa M, Yong William H, Kuhn John G, Mischel Paul S, Mehta Minesh P, Cloughesy Timothy F, Mellinghoff Ingo K, Differential sensitivity of glioma- versus lung cancer-specific EGFR mutations to EGFR kinase inhibitors. Cancer discovery. 2012; 2(5): 458-71.
Ho Melissa E, Quek Sue-Ing, True Lawrence D, Morrissey Colm, Corey Eva, Vessella Robert L, Dumpit Ruth, Nelson Peter S, Maresh Erin L, Mah Vei, Alavi Mohammed, Kim Sara R, Bagryanova Lora, Horvath Steve, Chia David, Goodglick Lee, Liu Alvin Y, Prostate cancer cell phenotypes based on AGR2 and CD10 expression. Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc. 2013; 26(6): 849-59.
Hilliard Austin T, Miller Julie E, Fraley Elizabeth R, Horvath Steve, White Stephanie A, Molecular microcircuitry underlies functional specification in a basal ganglia circuit dedicated to vocal learning. Neuron. 2012; 73(3): 537-52.
Langfelder Peter, Horvath Steve, Fast R Functions for Robust Correlations and Hierarchical Clustering. Journal of statistical software. 2012; 46(11): .
Miller Jeremy A, Woltjer Randall L, Goodenbour Jeff M, Horvath Steve, Geschwind Daniel H, Genes and pathways underlying regional and cell type changes in Alzheimer's disease. Genome medicine. 2013; 5(5): 48.
Langfelder Peter, Mischel Paul S, Horvath Steve, When is hub gene selection better than standard meta-analysis?. PloS one. 2013; 8(4): e61505.
Ranola John Michael, Langfelder Peter, Lange Kenneth, Horvath Steve, Cluster and propensity based approximation of a network. BMC systems biology. 2013; 7(4): 21.
Diekstra Frank P, Saris Christiaan G J, van Rheenen Wouter, Franke Lude, Jansen Ritsert C, van Es Michael A, van Vught Paul W J, Blauw Hylke M, Groen Ewout J N, Horvath Steve, Estrada Karol, Rivadeneira Fernando, Hofman Albert, Uitterlinden Andre G, Robberecht Wim, Andersen Peter M, Melki Judith, Meininger Vincent, Hardiman Orla, Landers John E, Brown Robert H, Shatunov Aleksey, Shaw Christopher E, Leigh P Nigel, Al-Chalabi Ammar, Ophoff Roel A, van den Berg Leonard H, Veldink Jan H, Mapping of gene expression reveals CYP27A1 as a susceptibility gene for sporadic ALS. PloS one. 2012; 7(4): e35333.
Levine Andrew J, Miller Jeremy A, Shapshak Paul, Gelman Benjamin, Singer Elyse J, Hinkin Charles H, Commins Deborah, Morgello Susan, Grant Igor, Horvath Steve, Systems analysis of human brain gene expression: mechanisms for HIV-associated neurocognitive impairment and common pathways with Alzheimer's disease. BMC medical genomics. 2013; 6(4): 4.
Leuchter Andrew F, Cook Ian A, Hunter Aimee M, Cai Chaochao, Horvath Steve, Resting-state quantitative electroencephalography reveals increased neurophysiologic connectivity in depression. PloS one. 2012; 7(2): e32508.
Song Lin, Langfelder Peter, Horvath Steve, Random generalized linear model: a highly accurate and interpretable ensemble predictor. BMC bioinformatics. 2013; 14(4): 5.
Song Lin, Langfelder Peter, Horvath Steve, Comparison of co-expression measures: mutual information, correlation, and model based indices. BMC bioinformatics. 2012; 13(4): 328.
Wang Anyou, Huang Kevin, Shen Yin, Xue Zhigang, Cai Chaochao, Horvath Steve, Fan Guoping, Functional modules distinguish human induced pluripotent stem cells from embryonic stem cells. Stem cells and development. 2011; 20(11): 1937-50.
Haas Blake E, Horvath Steve, Pietiläinen Kirsi H, Cantor Rita M, Nikkola Elina, Weissglas-Volkov Daphna, Rissanen Aila, Civelek Mete, Cruz-Bautista Ivette, Riba Laura, Kuusisto Johanna, Kaprio Jaakko, Tusie-Luna Teresa, Laakso Markku, Aguilar-Salinas Carlos A, Pajukanta Päivi, Adipose co-expression networks across Finns and Mexicans identify novel triglyceride-associated genes. BMC medical genomics. 2012; 5(4): 61.
Miller Jeremy A, Cai Chaochao, Langfelder Peter, Geschwind Daniel H, Kurian Sunil M, Salomon Daniel R, Horvath Steve, Strategies for aggregating gene expression data: the collapseRows R function. BMC bioinformatics. 2011; 12(11): 322.
van Eijk Kristel R, de Jong Simone, Boks Marco P M, Langeveld Terry, Colas Fabrice, Veldink Jan H, de Kovel Carolien G F, Janson Esther, Strengman Eric, Langfelder Peter, Kahn René S, van den Berg Leonard H, Horvath Steve, Ophoff Roel A, Genetic analysis of DNA methylation and gene expression levels in whole blood of healthy human subjects. BMC genomics. 2012; 13(4): 636.
Horvath Steve, Nazmul-Hossain Abu Nm, Pollard Rodney Pe, Kroese Frans Gm, Vissink Arjan, Kallenberg Cees Gm, Spijkervet Fred Kl, Bootsma Hendrika, Michie Sara A, Gorr Sven U, Peck Ammon B, Cai Chaochao, Zhou Hui, Wong David Tw, Systems analysis of primary Sjögren's syndrome pathogenesis in salivary glands identifies shared pathways in human and a mouse model. Arthritis research & therapy. 2012; 14(6): R238.
Marquez-Garban Diana C, Mah Vei, Alavi Mohammad, Maresh Erin L, Chen Hsiao-Wang, Bagryanova Lora, Horvath Steve, Chia David, Garon Edward, Goodglick Lee, Pietras Richard J, Progesterone and estrogen receptor expression and activity in human non-small cell lung cancer. Steroids. 2011; 76(9): 910-20.
Horvath Steve, Zhang Yafeng, Langfelder Peter, Kahn René S, Boks Marco Pm, van Eijk Kristel, van den Berg Leonard H, Ophoff Roel A, Aging effects on DNA methylation modules in human brain and blood tissue. Genome biology. 2012; 13(10): R97.
Dewey Frederick E, Perez Marco V, Wheeler Matthew T, Watt Clifton, Spin Joshua, Langfelder Peter, Horvath Steve, Hannenhalli Sridhar, Cappola Thomas P, Ashley Euan A, Gene coexpression network topology of cardiac development, hypertrophy, and failure. Circulation. Cardiovascular genetics. 2011; 4(1): 26-35.
Huerta-Yepez Sara, Yoon Nam K, Hernandez-Cueto Angeles, Mah Vei, Rivera-Pazos Clara M, Chatterjee Devasis, Vega Mario I, Maresh Erin L, Horvath Steve, Chia David, Bonavida Benjamin, Goodglick Lee, Expression of phosphorylated raf kinase inhibitor protein (pRKIP) is a predictor of lung cancer survival. BMC cancer. 2011; 11(9): 259.
Langfelder Peter, Luo Rui, Oldham Michael C, Horvath Steve, Is my network module preserved and reproducible?. PLoS computational biology. 2011; 7(1): e1001057.
Shirasaki Dyna I, Greiner Erin R, Al-Ramahi Ismael, Gray Michelle, Boontheung Pinmanee, Geschwind Daniel H, Botas Juan, Coppola Giovanni, Horvath Steve, Loo Joseph A, Yang X William, Network organization of the huntingtin proteomic interactome in mammalian brain. Neuron. 2012; 75(1): 41-57.
Gorr Sven-Ulrik, Wennblom Trevor J, Horvath Steve, Wong David T W, Michie Sara A, Text-mining applied to autoimmune disease research: the Sjögren's syndrome knowledge base. BMC musculoskeletal disorders. 2012; 13(1): 119.
Oldham Michael C, Langfelder Peter, Horvath Steve, Network methods for describing sample relationships in genomic datasets: application to Huntington's disease. BMC systems biology. 2012; 6(1): 63.
Hilliard Austin T, Miller Julie E, Horvath Steve, White Stephanie A, Distinct neurogenomic states in basal ganglia subregions relate differently to singing behavior in songbirds. PLoS computational biology. 2012; 8(11): e1002773.
de Jong Simone, Boks Marco P M, Fuller Tova F, Strengman Eric, Janson Esther, de Kovel Carolien G F, Ori Anil P S, Vi Nancy, Mulder Flip, Blom Jan Dirk, Glenthøj Birte, Schubart Chris D, Cahn Wiepke, Kahn René S, Horvath Steve, Ophoff Roel A, A gene co-expression network in whole blood of schizophrenia patients is independent of antipsychotic-use and enriched for brain-expressed genes. PloS one. 2012; 7(6): e39498.
Xue Zhigang, Huang Kevin, Cai Chaochao, Cai Lingbo, Jiang Chun-yan, Feng Yun, Liu Zhenshan, Zeng Qiao, Cheng Liming, Sun Yi E, Liu Jia-yin, Horvath Steve, Fan Guoping, Genetic programs in human and mouse early embryos revealed by single-cell RNA sequencing. Nature. 2013; 500(7464): 593-7.
Luykx Jurjen J, Bakker Steven C, Lentjes Eef, Boks Marco P M, van Geloven Nan, Eijkemans Marinus J C, Janson Esther, Strengman Eric, de Lepper Anne M, Westenberg Herman, Klopper Kai E, Hoorn Hendrik J, Gelissen Harry P M M, Jordan Julian, Tolenaar Noortje M, van Dongen Eric P A, Michel Bregt, Abramovic Lucija, Horvath Steve, Kappen Teus, Bruins Peter, Keijzers Peter, Borgdorff Paul, Ophoff Roel A, Kahn René S, Season of sampling and season of birth influence serotonin metabolite levels in human cerebrospinal fluid. PloS one. 2012; 7(2): e30497.
Hawrylycz Michael J, Lein Ed S, Guillozet-Bongaarts Angela L, Shen Elaine H, Ng Lydia, Miller Jeremy A, van de Lagemaat Louie N, Smith Kimberly A, Ebbert Amanda, Riley Zackery L, Abajian Chris, Beckmann Christian F, Bernard Amy, Bertagnolli Darren, Boe Andrew F, Cartagena Preston M, Chakravarty M Mallar, Chapin Mike, Chong Jimmy, Dalley Rachel A, Daly Barry David, Dang Chinh, Datta Suvro, Dee Nick, Dolbeare Tim A, Faber Vance, Feng David, Fowler David R, Goldy Jeff, Gregor Benjamin W, Haradon Zeb, Haynor David R, Hohmann John G, Horvath Steve, Howard Robert E, Jeromin Andreas, Jochim Jayson M, Kinnunen Marty, Lau Christopher, Lazarz Evan T, Lee Changkyu, Lemon Tracy A, Li Ling, Li Yang, Morris John A, Overly Caroline C, Parker Patrick D, Parry Sheana E, Reding Melissa, Royall Joshua J, Schulkin Jay, Sequeira Pedro Adolfo, Slaughterbeck Clifford R, Smith Simon C, Sodt Andy J, Sunkin Susan M, Swanson Beryl E, Vawter Marquis P, Williams Derric, Wohnoutka Paul, Zielke H Ronald, Geschwind Daniel H, Hof Patrick R, Smith Stephen M, Koch Christof, Grant Seth G N, Jones Allan R, An anatomically comprehensive atlas of the adult human brain transcriptome. Nature. 2012; 489(7416): 391-9.
Bocklandt Sven, Lin Wen, Sehl Mary E, Sánchez Francisco J, Sinsheimer Janet S, Horvath Steve, Vilain Eric, Epigenetic predictor of age. PloS one. 2011; 6(6): e14821.
Weiss James N, Karma Alain, MacLellan W Robb, Deng Mario, Rau Christoph D, Rees Colin M, Wang Jessica, Wisniewski Nicholas, Eskin Eleazar, Horvath Steve, Qu Zhilin, Wang Yibin, Lusis Aldons J, "Good enough solutions" and the genetics of complex diseases. Circulation research. 2012; 111(4): 493-504.
Horvath Steve, Pirazzini Chiara, Bacalini Maria Giulia, Gentilini Davide, Di Blasio Anna Maria, Delledonne Massimo, Mari Daniela, Arosio Beatrice, Monti Daniela, Passarino Giuseppe, De Rango Francesco, D'Aquila Patrizia, Giuliani Cristina, Marasco Elena, Collino Sebastiano, Descombes Patrick, Garagnani Paolo, Franceschi Claudio, Decreased epigenetic age of PBMCs from Italian semi-supercentenarians and their offspring. Aging. 2015; 7(12): 1159-70.
Horvath Steve, Levine Andrew J, HIV-1 Infection Accelerates Age According to the Epigenetic Clock. The Journal of infectious diseases. 2015; 212(10): 1563-73.
Duan Hongmei, Ge Weihong, Zhang Aifeng, Xi Yue, Chen Zhihua, Luo Dandan, Cheng Yin, Fan Kevin S, Horvath Steve, Sofroniew Michael V, Cheng Liming, Yang Zhaoyang, Sun Yi E, Li Xiaoguang, Transcriptome analyses reveal molecular mechanisms underlying functional recovery after spinal cord injury. Proceedings of the National Academy of Sciences of the United States of America. 2015; 112(43): 13360-5.
Alavi Mohammed, Mah Vei, Maresh Erin L, Bagryanova Lora, Horvath Steve, Chia David, Goodglick Lee, Liu Alvin Y, High expression of AGR2 in lung cancer is predictive of poor survival. BMC cancer. 2015; 15(43): 655.
Levine Morgan E, Hosgood H Dean, Chen Brian, Absher Devin, Assimes Themistocles, Horvath Steve, DNA methylation age of blood predicts future onset of lung cancer in the women's health initiative. Aging. 2015; 7(9): 690-700.
van Eijk Kristel R, de Jong Simone, Strengman Eric, Buizer-Voskamp Jacobine E, Kahn René S, Boks Marco P, Horvath Steve, Ophoff Roel A, Identification of schizophrenia-associated loci by combining DNA methylation and gene expression data from whole blood. European journal of human genetics : EJHG. 2015; 23(8): 1106-10.
Marioni Riccardo E, Shah Sonia, McRae Allan F, Ritchie Stuart J, Muniz-Terrera Graciela, Harris Sarah E, Gibson Jude, Redmond Paul, Cox Simon R, Pattie Alison, Corley Janie, Taylor Adele, Murphy Lee, Starr John M, Horvath Steve, Visscher Peter M, Wray Naomi R, Deary Ian J, The epigenetic clock is correlated with physical and cognitive fitness in the Lothian Birth Cohort 1936. International journal of epidemiology. 2015; 44(4): 1388-96.
Horvath Steve, Garagnani Paolo, Bacalini Maria Giulia, Pirazzini Chiara, Salvioli Stefano, Gentilini Davide, Di Blasio Anna Maria, Giuliani Cristina, Tung Spencer, Vinters Harry V, Franceschi Claudio, Accelerated epigenetic aging in Down syndrome. Aging cell. 2015; 14(3): 491-5.
Mah Vei, Alavi Mohammad, Márquez-Garbán Diana C, Maresh Erin L, Kim Sara R, Horvath Steve, Bagryanova Lora, Huerta-Yepez Sara, Chia David, Pietras Richard, Goodglick Lee, Ribonucleotide reductase subunit M2 predicts survival in subgroups of patients with non-small cell lung carcinoma: effects of gender and smoking status. PloS one. 2015; 10(5): e0127600.
Luo Yuping, Coskun Volkan, Liang Aibing, Yu Juehua, Cheng Liming, Ge Weihong, Shi Zhanping, Zhang Kunshan, Li Chun, Cui Yaru, Lin Haijun, Luo Dandan, Wang Junbang, Lin Connie, Dai Zachary, Zhu Hongwen, Zhang Jun, Liu Jie, Liu Hailiang, deVellis Jean, Horvath Steve, Sun Yi Eve, Li Siguang, Single-cell transcriptome analyses reveal signals to activate dormant neural stem cells. Cell. 2015; 161(5): 1175-86.
Horvath Steve, Erratum to: DNA methylation age of human tissues and cell types. Genome biology. 2015; 16(5): 96.
Horvath Steve, Mah Vei, Lu Ake T, Woo Jennifer S, Choi Oi-Wa, Jasinska Anna J, Riancho José A, Tung Spencer, Coles Natalie S, Braun Jonathan, Vinters Harry V, Coles L Stephen, The cerebellum ages slowly according to the epigenetic clock. Aging. 2015; 7(5): 294-306.
Walker Richard F, Liu Jia Sophie, Peters Brock A, Ritz Beate R, Wu Timothy, Ophoff Roel A, Horvath Steve, Epigenetic age analysis of children who seem to evade aging. Aging. 2015; 7(5): 334-9.
Marioni Riccardo E, Shah Sonia, McRae Allan F, Chen Brian H, Colicino Elena, Harris Sarah E, Gibson Jude, Henders Anjali K, Redmond Paul, Cox Simon R, Pattie Alison, Corley Janie, Murphy Lee, Martin Nicholas G, Montgomery Grant W, Feinberg Andrew P, Fallin M Daniele, Multhaup Michael L, Jaffe Andrew E, Joehanes Roby, Schwartz Joel, Just Allan C, Lunetta Kathryn L, Murabito Joanne M, Starr John M, Horvath Steve, Baccarelli Andrea A, Levy Daniel, Visscher Peter M, Wray Naomi R, Deary Ian J, DNA methylation age of blood predicts all-cause mortality in later life. Genome biology. 2015; 16(3): 25.
Rickabaugh Tammy M, Baxter Ruth M, Sehl Mary, Sinsheimer Janet S, Hultin Patricia M, Hultin Lance E, Quach Austin, Martínez-Maza Otoniel, Horvath Steve, Vilain Eric, Jamieson Beth D, Acceleration of age-associated methylation patterns in HIV-1-infected adults. PloS one. 2015; 10(3): e0119201.
Boks Marco P, van Mierlo Hans C, Rutten Bart P F, Radstake Timothy R D J, De Witte Lot, Geuze Elbert, Horvath Steve, Schalkwyk Leonard C, Vinkers Christiaan H, Broen Jasper C A, Vermetten Eric, Longitudinal changes of telomere length and epigenetic age related to traumatic stress and post-traumatic stress disorder. Psychoneuroendocrinology. 2015; 51(3): 506-12.
Horvath Steve, Erhart Wiebke, Brosch Mario, Ammerpohl Ole, von Schönfels Witigo, Ahrens Markus, Heits Nils, Bell Jordana T, Tsai Pei-Chien, Spector Tim D, Deloukas Panos, Siebert Reiner, Sipos Bence, Becker Thomas, Röcken Christoph, Schafmayer Clemens, Hampe Jochen, Obesity accelerates epigenetic aging of human liver. Proceedings of the National Academy of Sciences of the United States of America. 2014; 111(43): 15538-43.
Tian Yuan, Voineagu Irina, Paşca Sergiu P, Won Hyejung, Chandran Vijayendran, Horvath Steve, Dolmetsch Ricardo E, Geschwind Daniel H, Alteration in basal and depolarization induced transcriptional network in iPSC derived neurons from Timothy syndrome. Genome medicine. 2014; 6(10): 75.
Montoya Dennis, Inkeles Megan S, Liu Phillip T, Realegeno Susan, Teles Rosane M B, Vaidya Poorva, Munoz Marcos A, Schenk Mirjam, Swindell William R, Chun Rene, Zavala Kathryn, Hewison Martin, Adams John S, Horvath Steve, Pellegrini Matteo, Bloom Barry R, Modlin Robert L, IL-32 is a molecular marker of a host defense network in human tuberculosis. Science translational medicine. 2014; 6(250): 250ra114.
De Jong Simone, Neeleman Marjolein, Luykx Jurjen J, ten Berg Maarten J, Strengman Eric, Den Breeijen Hanneke H, Stijvers Leon C, Buizer-Voskamp Jacobine E, Bakker Steven C, Kahn René S, Horvath Steve, Van Solinge Wouter W, Ophoff Roel A, Seasonal changes in gene expression represent cell-type composition in whole blood. Human molecular genetics. 2014; 23(10): 2721-8.
Khalid Omar, Kim Jeffrey J, Kim Hyun-Sung, Hoang Michael, Tu Thanh G, Elie Omid, Lee Connie, Vu Catherine, Horvath Steve, Spigelman Igor, Kim Yong, Gene expression signatures affected by alcohol-induced DNA methylomic deregulation in human embryonic stem cells. Stem cell research. 2014; 12(3): 791-806.
Corominas Roser, Yang Xinping, Lin Guan Ning, Kang Shuli, Shen Yun, Ghamsari Lila, Broly Martin, Rodriguez Maria, Tam Stanley, Trigg Shelly A, Fan Changyu, Yi Song, Tasan Murat, Lemmens Irma, Kuang Xingyan, Zhao Nan, Malhotra Dheeraj, Michaelson Jacob J, Vacic Vladimir, Calderwood Michael A, Roth Frederick P, Tavernier Jan, Horvath Steve, Salehi-Ashtiani Kourosh, Korkin Dmitry, Sebat Jonathan, Hill David E, Hao Tong, Vidal Marc, Iakoucheva Lilia M, Protein interaction network of alternatively spliced isoforms from brain links genetic risk factors for autism. Nature communications. 2014; 5(3): 3650.
Levine Andrew J, Panos Stella E, Horvath Steve, Genetic, transcriptomic, and epigenetic studies of HIV-associated neurocognitive disorder. Journal of acquired immune deficiency syndromes (1999). 2014; 65(4): 481-503.
Levine Andrew J, Horvath Steve, Miller Eric N, Singer Elyse J, Shapshak Paul, Baldwin Gayle C, Martínez-Maza Otoniel, Witt Mallory D, Langfelder Peter, Transcriptome analysis of HIV-infected peripheral blood monocytes: gene transcripts and networks associated with neurocognitive functioning. Journal of neuroimmunology. 2013; 265(1-2): 96-105.
Li Yun, Chen Jason A, Sears Renee L, Gao Fuying, Klein Eric D, Karydas Anna, Geschwind Michael D, Rosen Howard J, Boxer Adam L, Guo Weilong, Pellegrini Matteo, Horvath Steve, Miller Bruce L, Geschwind Daniel H, Coppola Giovanni, An epigenetic signature in peripheral blood associated with the haplotype on 17q21.31, a risk factor for neurodegenerative tauopathy. PLoS genetics. 2014; 10(3): e1004211.
Parikshak Neelroop N, Luo Rui, Zhang Alice, Won Hyejung, Lowe Jennifer K, Chandran Vijayendran, Horvath Steve, Geschwind Daniel H, Integrative functional genomic analyses implicate specific molecular pathways and circuits in autism. Cell. 2013; 155(5): 1008-21.
Tong Maomeng, Li Xiaoxiao, Wegener Parfrey Laura, Roth Bennett, Ippoliti Andrew, Wei Bo, Borneman James, McGovern Dermot P B, Frank Daniel N, Li Ellen, Horvath Steve, Knight Rob, Braun Jonathan, A modular organization of the human intestinal mucosal microbiota and its association with inflammatory bowel disease. PloS one. 2013; 8(11): e80702.
McHardy Ian H, Goudarzi Maryam, Tong Maomeng, Ruegger Paul M, Schwager Emma, Weger John R, Graeber Thomas G, Sonnenburg Justin L, Horvath Steve, Huttenhower Curtis, McGovern Dermot Pb, Fornace Albert J, Borneman James, Braun Jonathan, Integrative analysis of the microbiome and metabolome of the human intestinal mucosal surface reveals exquisite inter-relationships. Microbiome. 2013; 1(1): 17.
Horvath Steve, DNA methylation age of human tissues and cell types. Genome biology. 2013; 14(10): R115.
Thompson Michael J, vonHoldt Bridgett, Horvath Steve, Pellegrini Matteo, An epigenetic aging clock for dogs and wolves. Aging. 2017; 9(3): 1055-1068.
Crandall Carolyn J, Manson JoAnn E, Hohensee Chancellor, Horvath Steve, Wactawski-Wende Jean, LeBlanc Erin S, Vitolins Mara Z, Nassir Rami, Sinsheimer Janet S, Association of genetic variation in the tachykinin receptor 3 locus with hot flashes and night sweats in the Women's Health Initiative Study. Menopause (New York, N.Y.). 2017; 24(3): 252-261.
Leung Janice M, Fishbane Nick, Jones Meaghan, Morin Alexander, Xu Stella, Liu Joseph Cy, MacIsaac Julie, Milloy M-J, Hayashi Kanna, Montaner Julio, Horvath Steve, Kobor Michael, Sin Don D, Harrigan P Richard, Man S F Paul, Longitudinal study of surrogate aging measures during human immunodeficiency virus seroconversion. Aging. 2017; 9(3): 687-705.
Quach Austin, Levine Morgan E, Tanaka Toshiko, Lu Ake T, Chen Brian H, Ferrucci Luigi, Ritz Beate, Bandinelli Stefania, Neuhouser Marian L, Beasley Jeannette M, Snetselaar Linda, Wallace Robert B, Tsao Philip S, Absher Devin, Assimes Themistocles L, Stewart James D, Li Yun, Hou Lifang, Baccarelli Andrea A, Whitsel Eric A, Horvath Steve, Epigenetic clock analysis of diet, exercise, education, and lifestyle factors. Aging. 2017; 9(2): 419-446.
Carroll Judith E, Irwin Michael R, Levine Morgan, Seeman Teresa E, Absher Devin, Assimes Themistocles, Horvath Steve, Epigenetic Aging and Immune Senescence in Women With Insomnia Symptoms: Findings From the Women's Health Initiative Study. Biological psychiatry. 2017; 81(2): 136-144.
Parikshak Neelroop N, Swarup Vivek, Belgard T Grant, Irimia Manuel, Ramaswami Gokul, Gandal Michael J, Hartl Christopher, Leppa Virpi, Ubieta Luis de la Torre, Huang Jerry, Lowe Jennifer K, Blencowe Benjamin J, Horvath Steve, Geschwind Daniel H, Genome-wide changes in lncRNA, splicing, and regional gene expression patterns in autism. Nature. 2016; 540(7633): 423-427.
Ligthart Symen, Marzi Carola, Aslibekyan Stella, Mendelson Michael M, Conneely Karen N, Tanaka Toshiko, Colicino Elena, Waite Lindsay L, Joehanes Roby, Guan Weihua, Brody Jennifer A, Elks Cathy, Marioni Riccardo, Jhun Min A, Agha Golareh, Bressler Jan, Ward-Caviness Cavin K, Chen Brian H, Huan Tianxiao, Bakulski Kelly, Salfati Elias L, Salfati Elias L, Fiorito Giovanni, Fiorito Giovanni, Wahl Simone, Schramm Katharina, Sha Jin, Hernandez Dena G, Just Allan C, Smith Jennifer A, Sotoodehnia Nona, Pilling Luke C, Pankow James S, Tsao Phil S, Liu Chunyu, Zhao Wei, Guarrera Simonetta, Michopoulos Vasiliki J, Smith Alicia K, Peters Marjolein J, Melzer David, Vokonas Pantel, Fornage Myriam, Prokisch Holger, Bis Joshua C, Chu Audrey Y, Herder Christian, Grallert Harald, Yao Chen, Shah Sonia, McRae Allan F, Lin Honghuang, Horvath Steve, Fallin Daniele, Hofman Albert, Wareham Nicholas J, Wiggins Kerri L, Feinberg Andrew P, Starr John M, Visscher Peter M, Murabito Joanne M, Kardia Sharon L R, Absher Devin M, Binder Elisabeth B, Singleton Andrew B, Bandinelli Stefania, Peters Annette, Waldenberger Melanie, Matullo Giuseppe, Schwartz Joel D, Demerath Ellen W, Uitterlinden André G, van Meurs Joyce B J, Franco Oscar H, Chen Yii-Der Ida, Levy Daniel, Turner Stephen T, Deary Ian J, Ressler Kerry J, Dupuis Josée, Ferrucci Luigi, Ong Ken K, Assimes Themistocles L, Boerwinkle Eric, Koenig Wolfgang, Arnett Donna K, Baccarelli Andrea A, Benjamin Emelia J, Dehghan Abbas, DNA methylation signatures of chronic low-grade inflammation are associated with complex diseases. Genome biology. 2016; 17(1): 255.
Liu Xian, Grogan Tristan R, Hieronymus Haley, Hashimoto Takao, Mottahedeh Jack, Cheng Donghui, Zhang Lijun, Huang Kevin, Stoyanova Tanya, Park Jung Wook, Shkhyan Ruzanna O, Nowroozizadeh Behdokht, Rettig Matthew B, Sawyers Charles L, Elashoff David, Horvath Steve, Huang Jiaoti, Witte Owen N, Goldstein Andrew S, Low CD38 Identifies Progenitor-like Inflammation-Associated Luminal Cells that Can Initiate Human Prostate Cancer and Predict Poor Outcome. Cell reports. 2016; 17(10): 2596-2606.
Stölzel Friedrich, Brosch Mario, Horvath Steve, Kramer Michael, Thiede Christian, von Bonin Malte, Ammerpohl Ole, Middeke Moritz, Schetelig Johannes, Ehninger Gerhard, Hampe Jochen, Bornhäuser Martin, Dynamics of epigenetic age following hematopoietic stem cell transplantation. Haematologica. 2017; 102(8): e321-e323.
Knight Anna K, Craig Jeffrey M, Theda Christiane, Bækvad-Hansen Marie, Bybjerg-Grauholm Jonas, Hansen Christine S, Hollegaard Mads V, Hougaard David M, Mortensen Preben B, Weinsheimer Shantel M, Werge Thomas M, Brennan Patricia A, Cubells Joseph F, Newport D Jeffrey, Stowe Zachary N, Cheong Jeanie L Y, Dalach Philippa, Doyle Lex W, Loke Yuk J, Baccarelli Andrea A, Just Allan C, Wright Robert O, Téllez-Rojo Mara M, Svensson Katherine, Trevisi Letizia, Kennedy Elizabeth M, Binder Elisabeth B, Iurato Stella, Czamara Darina, Räikkönen Katri, Lahti Jari M T, Pesonen Anu-Katriina, Kajantie Eero, Villa Pia M, Laivuori Hannele, Hämäläinen Esa, Park Hea Jin, Bailey Lynn B, Parets Sasha E, Kilaru Varun, Menon Ramkumar, Horvath Steve, Bush Nicole R, LeWinn Kaja Z, Tylavsky Frances A, Conneely Karen N, Smith Alicia K, An epigenetic clock for gestational age at birth based on blood methylation data. Genome biology. 2016; 17(1): 206.
Sehl Mary E, Henry Jill E, Storniolo Anna Maria, Ganz Patricia A, Horvath Steve, DNA methylation age is elevated in breast tissue of healthy women. Breast cancer research and treatment. 2017; 164(1): 209-219.
Chen Brian H, Marioni Riccardo E, Colicino Elena, Peters Marjolein J, Ward-Caviness Cavin K, Tsai Pei-Chien, Roetker Nicholas S, Just Allan C, Demerath Ellen W, Guan Weihua, Bressler Jan, Fornage Myriam, Studenski Stephanie, Vandiver Amy R, Moore Ann Zenobia, Tanaka Toshiko, Kiel Douglas P, Liang Liming, Vokonas Pantel, Schwartz Joel, Lunetta Kathryn L, Murabito Joanne M, Bandinelli Stefania, Hernandez Dena G, Melzer David, Nalls Michael, Pilling Luke C, Price Timothy R, Singleton Andrew B, Gieger Christian, Holle Rolf, Kretschmer Anja, Kronenberg Florian, Kunze Sonja, Linseisen Jakob, Meisinger Christine, Rathmann Wolfgang, Waldenberger Melanie, Visscher Peter M, Shah Sonia, Wray Naomi R, McRae Allan F, Franco Oscar H, Hofman Albert, Uitterlinden André G, Absher Devin, Assimes Themistocles, Levine Morgan E, Lu Ake T, Tsao Philip S, Hou Lifang, Manson JoAnn E, Carty Cara L, LaCroix Andrea Z, Reiner Alexander P, Spector Tim D, Feinberg Andrew P, Levy Daniel, Baccarelli Andrea, van Meurs Joyce, Bell Jordana T, Peters Annette, Deary Ian J, Pankow James S, Ferrucci Luigi, Horvath Steve, DNA methylation-based measures of biological age: meta-analysis predicting time to death. Aging. 2016; 8(9): 1844-1865.
Vidal-Bralo Laura, Lopez-Golan Yolanda, Mera-Varela Antonio, Rego-Perez Ignacio, Horvath Steve, Zhang Yuhua, Del Real Álvaro, Zhai Guangju, Blanco Francisco J, Riancho Jose A, Gomez-Reino Juan J, Gonzalez Antonio, Specific premature epigenetic aging of cartilage in osteoarthritis. Aging. 2016; 8(9): 2222-2231.
Kozlenkov Alexey, Jaffe Andrew E, Timashpolsky Alisa, Apontes Pasha, Rudchenko Sergei, Barbu Mihaela, Byne William, Hurd Yasmin L, Horvath Steve, Dracheva Stella, DNA Methylation Profiling of Human Prefrontal Cortex Neurons in Heroin Users Shows Significant Difference between Genomic Contexts of Hyper- and Hypomethylation and a Younger Epigenetic Age. Genes. 2017; 8(6): 209-219.
Huh Christine J, Zhang Bo, Victor Matheus B, Dahiya Sonika, Batista Luis Fz, Horvath Steve, Yoo Andrew S, Maintenance of age in human neurons generated by microRNA-based neuronal conversion of fibroblasts. eLife. 2016; 5(9): 2222-2231.
Lu Ake T, Hannon Eilis, Levine Morgan E, Crimmins Eileen M, Lunnon Katie, Mill Jonathan, Geschwind Daniel H, Horvath Steve, Genetic architecture of epigenetic and neuronal ageing rates in human brain regions. Nature communications. 2017; 8(6): 15353.
Li Dongcui, Hsu Raymond, Figura Brian, Jacobs Robert, Li Sinan, Horvath Steve, Clifford Ted, Chari Krishnan, Rheology and structure of surface crosslinked surfactant-activated microgels. Soft matter. 2016; 12(34): 7150-8.
Chuang Yu-Hsuan, Quach Austin, Absher Devin, Assimes Themistocles, Horvath Steve, Ritz Beate, Coffee consumption is associated with DNA methylation levels of human blood. European journal of human genetics : EJHG. 2017; 25(5): 608-616.
Levine Morgan E, Lu Ake T, Chen Brian H, Hernandez Dena G, Singleton Andrew B, Ferrucci Luigi, Bandinelli Stefania, Salfati Elias, Manson JoAnn E, Quach Austin, Kusters Cynthia D J, Kuh Diana, Wong Andrew, Teschendorff Andrew E, Widschwendter Martin, Ritz Beate R, Absher Devin, Assimes Themistocles L, Horvath Steve, Menopause accelerates biological aging. Proceedings of the National Academy of Sciences of the United States of America. 2016; 113(33): 9327-32.
Maierhofer Anna, Flunkert Julia, Oshima Junko, Martin George M, Haaf Thomas, Horvath Steve, Accelerated epigenetic aging in Werner syndrome. Aging. 2017; 9(4): 1143-1152.
Horvath Steve, Gurven Michael, Levine Morgan E, Trumble Benjamin C, Kaplan Hillard, Allayee Hooman, Ritz Beate R, Chen Brian, Lu Ake T, Rickabaugh Tammy M, Jamieson Beth D, Sun Dianjianyi, Li Shengxu, Chen Wei, Quintana-Murci Lluis, Fagny Maud, Kobor Michael S, Tsao Philip S, Reiner Alexander P, Edlefsen Kerstin L, Absher Devin, Assimes Themistocles L, An epigenetic clock analysis of race/ethnicity, sex, and coronary heart disease. Genome biology. 2016; 17(1): 171.
Ambatipudi Srikant, Horvath Steve, Perrier Flavie, Cuenin Cyrille, Hernandez-Vargas Hector, Le Calvez-Kelm Florence, Durand Geoffroy, Byrnes Graham, Ferrari Pietro, Bouaoun Liacine, Sklias Athena, Chajes Véronique, Overvad Kim, Severi Gianluca, Baglietto Laura, Clavel-Chapelon Françoise, Kaaks Rudolf, Barrdahl Myrto, Boeing Heiner, Trichopoulou Antonia, Lagiou Pagona, Naska Androniki, Masala Giovanna, Agnoli Claudia, Polidoro Silvia, Tumino Rosario, Panico Salvatore, Dollé Martijn, Peeters Petra H M, Onland-Moret N Charlotte, Sandanger Torkjel M, Nøst Therese H, Weiderpass Elisabete, Quirós J Ramón, Agudo Antonio, Rodriguez-Barranco Miguel, Huerta Castaño José María, Barricarte Aurelio, Fernández Ander Matheu, Travis Ruth C, Vineis Paolo, Muller David C, Riboli Elio, Gunter Marc, Romieu Isabelle, Herceg Zdenko, DNA methylome analysis identifies accelerated epigenetic ageing associated with postmenopausal breast cancer susceptibility. European journal of cancer (Oxford, England : 1990). 2017; 75(4): 299-307.
Horvath Steve, Langfelder Peter, Kwak Seung, Aaronson Jeff, Rosinski Jim, Vogt Thomas F, Eszes Marika, Faull Richard L M, Curtis Maurice A, Waldvogel Henry J, Choi Oi-Wa, Tung Spencer, Vinters Harry V, Coppola Giovanni, Yang X William, Huntington's disease accelerates epigenetic aging of human brain and disrupts DNA methylation levels. Aging. 2016; 8(7): 1485-512.
Simpkin Andrew J, Howe Laura D, Tilling Kate, Gaunt Tom R, Lyttleton Oliver, McArdle Wendy L, Ring Susan M, Horvath Steve, Smith George Davey, Relton Caroline L, The epigenetic clock and physical development during childhood and adolescence: longitudinal analysis from a UK birth cohort. International journal of epidemiology. 2017; 46(2): 549-558.
Levine Andrew J, Quach Austin, Moore David J, Achim Cristian L, Soontornniyomkij Virawudh, Masliah Eliezer, Singer Elyse J, Gelman Benjamin, Nemanim Natasha, Horvath Steve, Accelerated epigenetic aging in brain is associated with pre-mortem HIV-associated neurocognitive disorders. Journal of neurovirology. 2016; 22(3): 366-75.
Li Xiaoxiao, LeBlanc James, Elashoff David, McHardy Ian, Tong Maomeng, Roth Bennett, Ippoliti Andrew, Barron Gildardo, McGovern Dermot, McDonald Keely, Newberry Rodney, Graeber Thomas, Horvath Steve, Goodglick Lee, Braun Jonathan, Microgeographic Proteomic Networks of the Human Colonic Mucosa and Their Association With Inflammatory Bowel Disease. Cellular and molecular gastroenterology and hepatology. 2016; 2(5): 567-583.
Langfelder Peter, Cantle Jeffrey P, Chatzopoulou Doxa, Wang Nan, Gao Fuying, Al-Ramahi Ismael, Lu Xiao-Hong, Ramos Eliana Marisa, El-Zein Karla, Zhao Yining, Deverasetty Sandeep, Tebbe Andreas, Schaab Christoph, Lavery Daniel J, Howland David, Kwak Seung, Botas Juan, Aaronson Jeffrey S, Rosinski Jim, Coppola Giovanni, Horvath Steve, Yang X William, Integrated genomics and proteomics define huntingtin CAG length-dependent networks in mice. Nature neuroscience. 2016; 19(4): 623-33.
Chandran Vijayendran, Coppola Giovanni, Nawabi Homaira, Omura Takao, Versano Revital, Huebner Eric A, Zhang Alice, Costigan Michael, Yekkirala Ajay, Barrett Lee, Blesch Armin, Michaelevski Izhak, Davis-Turak Jeremy, Gao Fuying, Langfelder Peter, Horvath Steve, He Zhigang, Benowitz Larry, Fainzilber Mike, Tuszynski Mark, Woolf Clifford J, Geschwind Daniel H, A Systems-Level Analysis of the Peripheral Nerve Intrinsic Axonal Growth Program. Neuron. 2016; 89(5): 956-70.
Hong Candice Sun, Graham Nicholas A, Gu Wen, Espindola Camacho Carolina, Mah Vei, Maresh Erin L, Alavi Mohammed, Bagryanova Lora, Krotee Pascal A L, Gardner Brian K, Behbahan Iman Saramipoor, Horvath Steve, Chia David, Mellinghoff Ingo K, Hurvitz Sara A, Dubinett Steven M, Critchlow Susan E, Kurdistani Siavash K, Goodglick Lee, Braas Daniel, Graeber Thomas G, Christofk Heather R, MCT1 Modulates Cancer Cell Pyruvate Export and Growth of Tumors that Co-express MCT1 and MCT4. Cell reports. 2016; 14(7): 1590-601.
Lowe Donna, Horvath Steve, Raj Kenneth, Epigenetic clock analyses of cellular senescence and ageing. Oncotarget. 2016; 7(8): 8524-31.
Lu Ake T, Hannon Eilis, Levine Morgan E, Hao Ke, Crimmins Eileen M, Lunnon Katie, Kozlenkov Alexey, Mill Jonathan, Dracheva Stella, Horvath Steve, Genetic variants near MLST8 and DHX57 affect the epigenetic age of the cerebellum. Nature communications. 2016; 7(8): 10561.
Simpkin Andrew J, Hemani Gibran, Suderman Matthew, Gaunt Tom R, Lyttleton Oliver, Mcardle Wendy L, Ring Susan M, Sharp Gemma C, Tilling Kate, Horvath Steve, Kunze Sonja, Peters Annette, Waldenberger Melanie, Ward-Caviness Cavin, Nohr Ellen A, Sørensen Thorkild I A, Relton Caroline L, Smith George Davey, Prenatal and early life influences on epigenetic age in children: a study of mother-offspring pairs from two cohort studies. Human molecular genetics. 2016; 25(1): 191-201.

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