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Heather Christofk, Ph.D. [ Edit Your Profile ]

Work Email Address: hchristofk@mednet.ucla.edu

Work Phone Number: 310-794-4248

Mailing Address:
390A BSRB
CA

Office Address:
390A BSRB
615 Charles E. Young Drive South
Los Angeles, CA 90095

Work
UCLA Associate Professor, Molecular & Medical Pharmacology

Research Interests

Pharmacology, Pharmacology - Molecular Pharmacology


Education:
Degrees:
Ph.D., Harvard University, 2002 - 2007
B.S., University of California, Los Angeles, 1998 - 2001
Academic Experience:
2007 University of California, San Francisco

About

Dr. Heather Christofk's research focuses on studying the regulation of metabolic switches in cells, with a specific emphasis on cancer cells. Through collaboration with other CTSI researchers and clinicians, she hopes to translate discoveries in the lab to novel cancer diagnostic and treatment strategies. She will be involved with the CTSI as a new faculty recruit who does translational research in the Pilot and Collaborative Translational and Clinical Studies program.

Publications
Williams Kevin J, Argus Joseph P, Zhu Yue, Wilks Moses Q, Marbois Beth N, York Autumn G, Kidani Yoko, Pourzia Alexandra L, Akhavan David, Lisiero Dominique N, Komisopoulou Evangelia, Henkin Amy H, Soto Horacio, Chamberlain Brian T, Vergnes Laurent, Jung Michael E, Torres Jorge Z, Liau Linda M, Christofk Heather R, Prins Robert M, Mischel Paul S, Reue Karen, Graeber Thomas G, Bensinger Steven J, An Essential Requirement for the SCAP/SREBP Signaling Axis to Protect Cancer Cells from Lipotoxicity. Cancer research. 2013; 73(9): 2850-2862.
Krall Abigail S, Christofk Heather R, Cancer: A metabolic metamorphosis. Nature. 2013; 496(7443): 38-40.
McBrian Matthew A, Behbahan Iman Saramipoor, Ferrari Roberto, Su Trent, Huang Ta-Wei, Li Kunwu, Hong Candice S, Christofk Heather R, Vogelauer Maria, Seligson David B, Kurdistani Siavash K, Histone acetylation regulates intracellular pH. Molecular cell. 2013; 49(2): 310-21.
Smith Kathleen B, Tran Linh M, Tam Brenna M, Shurell Elizabeth M, Li Yunfeng, Braas Daniel, Tap William D, Christofk Heather R, Dry Sarah M, Eilber Fritz C, Wu Hong, Novel dedifferentiated liposarcoma xenograft models reveal PTEN down-regulation as a malignant signature and response to PI3K pathway inhibition. The American journal of pathology. 2013; 182(4): 1400-11.
Nagaraj Raghavendra, Gururaja-Rao Shubha, Jones Kevin T, Slattery Matthew, Negre Nicolas, Braas Daniel, Christofk Heather, White Kevin P, Mann Richard, Banerjee Utpal, Control of mitochondrial structure and function by the Yorkie/YAP oncogenic pathway. Genes & development. 2012; 26(18): 2027-37.
Braas Daniel, Ahler Ethan, Tam Brenna, Nathanson David, Riedinger Mirielle, Benz Matthias R, Smith Kathleen B, Eilber Fritz C, Witte Owen N, Tap William D, Wu Hong, Christofk Heather R, Metabolomics strategy reveals subpopulation of liposarcomas sensitive to gemcitabine treatment. Cancer discovery. 2012; 2(12): 1109-17.
Bensinger Steven J, Christofk Heather R, New aspects of the Warburg effect in cancer cell biology. Seminars in cell & developmental biology. 2012; .
Anastasiou Dimitrios, Yu Yimin, Israelsen William J, Jiang Jian-Kang, Boxer Matthew B, Hong Bum Soo, Tempel Wolfram, Dimov Svetoslav, Shen Min, Jha Abhishek, Yang Hua, Mattaini Katherine R, Metallo Christian M, Fiske Brian P, Courtney Kevin D, Malstrom Scott, Khan Tahsin M, Kung Charles, Skoumbourdis Amanda P, Veith Henrike, Southall Noel, Walsh Martin J, Brimacombe Kyle R, Leister William, Lunt Sophia Y, Johnson Zachary R, Yen Katharine E, Kunii Kaiko, Davidson Shawn M, Christofk Heather R, Austin Christopher P, Inglese James, Harris Marian H, Asara John M, Stephanopoulos Gregory, Salituro Francesco G, Jin Shengfang, Dang Lenny, Auld Douglas S, Park Hee-Won, Cantley Lewis C, Thomas Craig J, Vander Heiden Matthew G, Pyruvate kinase M2 activators promote tetramer formation and suppress tumorigenesis. Nature chemical biology. 2012; 8(10): 839-47.
Vlashi Erina, Lagadec Chann, Vergnes Laurent, Matsutani Tomoo, Masui Kenta, Poulou Maria, Popescu Ruxandra, Della Donna Lorenza, Evers Patrick, Dekmezian Carmen, Reue Karen, Christofk Heather, Mischel Paul S, Pajonk Frank, Metabolic state of glioma stem cells and nontumorigenic cells. Proceedings of the National Academy of Sciences of the United States of America. 2011; 108(38): 16062-7.
Christofk Heather R, Wu Ning, Cantley Lewis C, Asara John M, Proteomic screening method for phosphopeptide motif binding proteins using peptide libraries. Journal of proteome research. 2011; 10(9): 4158-64.
Vander Heiden Matthew G, Locasale Jason W, Swanson Kenneth D, Sharfi Hadar, Heffron Greg J, Amador-Noguez Daniel, Christofk Heather R, Wagner Gerhard, Rabinowitz Joshua D, Asara John M, Cantley Lewis C, Evidence for an alternative glycolytic pathway in rapidly proliferating cells. Science (New York, N.Y.). 2010; 329(5998): 1492-9.
Vander Heiden Matthew G, Christofk Heather R, Schuman Eli, Subtelny Alexander O, Sharfi Hadar, Harlow Edward E, Xian Jun, Cantley Lewis C, Identification of small molecule inhibitors of pyruvate kinase M2. Biochemical pharmacology. 2009; .
Asara John M, Christofk Heather R, Freimark Lisa M, Cantley Lewis C, A label-free quantification method by MS/MS TIC compared to SILAC and spectral counting in a proteomics screen. Proteomics. 2008; 8(5): 994-9.
Christofk Heather R, Vander Heiden Matthew G, Wu Ning, Asara John M, Cantley Lewis C, Pyruvate kinase M2 is a phosphotyrosine-binding protein. Nature. 2008; 452(7184): 181-6.
Christofk Heather R, Vander Heiden Matthew G, Harris Marian H, Ramanathan Arvind, Gerszten Robert E, Wei Ru, Fleming Mark D, Schreiber Stuart L, Cantley Lewis C, The M2 splice isoform of pyruvate kinase is important for cancer metabolism and tumour growth. Nature. 2008; 452(7184): 230-3.
Asara John M, Zhang Xiang, Zheng Bin, Christofk Heather H, Wu Ning, Cantley Lewis C, In-Gel Stable-Isotope Labeling (ISIL): a strategy for mass spectrometry-based relative quantification. Journal of proteome research. 2006; 5(1): 155-63.
Asara John M, Zhang Xiang, Zheng Bin, Maroney Lisa A, Christofk Heather R, Wu Ning, Cantley Lewis C, In-gel stable isotope labeling for relative quantification using mass spectrometry. Nature protocols. 2006; 1(1): 46-51.
Wong Kelly A, Kim Rachel, Christofk Heather, Gao Jing, Lawson Gregory, Wu Hong, Protein inhibitor of activated STAT Y (PIASy) and a splice variant lacking exon 6 enhance sumoylation but are not essential for embryogenesis and adult life. Molecular and cellular biology. 2004; 24(12): 5577-86.
Babic Ivan, Anderson Erik S, Tanaka Kazuhiro, Guo Deliang, Masui Kenta, Li Bing, Zhu Shaojun, Gu Yuchao, Villa Genaro R, Akhavan David, Nathanson David, Gini Beatrice, Mareninov Sergey, Li Rui, Camacho Carolina Espindola, Kurdistani Siavash K, Eskin Ascia, Nelson Stanley F, Yong William H, Cavenee Webster K, Cloughesy Timothy F, Christofk Heather R, Black Douglas L, Mischel Paul S, EGFR mutation-induced alternative splicing of Max contributes to growth of glycolytic tumors in brain cancer. Cell metabolism. 2013; 17(6): 1000-8.
Chin Randall M, Fu Xudong, Pai Melody Y, Vergnes Laurent, Hwang Heejun, Deng Gang, Diep Simon, Lomenick Brett, Meli Vijaykumar S, Monsalve Gabriela C, Hu Eileen, Whelan Stephen A, Wang Jennifer X, Jung Gwanghyun, Solis Gregory M, Fazlollahi Farbod, Kaweeteerawat Chitrada, Quach Austin, Nili Mahta, Krall Abby S, Godwin Hilary A, Chang Helena R, Faull Kym F, Guo Feng, Jiang Meisheng, Trauger Sunia A, Saghatelian Alan, Braas Daniel, Christofk Heather R, Clarke Catherine F, Teitell Michael A, Petrascheck Michael, Reue Karen, Jung Michael E, Frand Alison R, Huang Jing, The metabolite α-ketoglutarate extends lifespan by inhibiting ATP synthase and TOR. Nature. 2014; 510(7505): 397-401.
Ahler Ethan, Sullivan William J, Cass Ashley, Braas Daniel, York Autumn G, Bensinger Steven J, Graeber Thomas G, Christofk Heather R, Doxycycline alters metabolism and proliferation of human cell lines. PloS one. 2013; 8(5): e64561.
Thai Minh, Graham Nicholas A, Braas Daniel, Nehil Michael, Komisopoulou Evangelia, Kurdistani Siavash K, McCormick Frank, Graeber Thomas G, Christofk Heather R, Adenovirus E4ORF1-induced MYC activation promotes host cell anabolic glucose metabolism and virus replication. Cell metabolism. 2014; 19(4): 694-701.
Domigan Courtney K, Warren Carmen M, Antanesian Vaspour, Happel Katharina, Ziyad Safiyyah, Lee Sunyoung, Krall Abigail, Duan Lewei, Torres-Collado Antoni X, Castellani Lawrence W, Elashoff David, Christofk Heather R, van der Bliek Alexander M, Potente Michael, Iruela-Arispe M Luisa, Autocrine VEGF maintains endothelial survival through regulation of metabolism and autophagy. Journal of cell science. 2015; 128(12): 2236-48.
Garon Edward B, Christofk Heather R, Hosmer Wylie, Britten Carolyn D, Bahng Agnes, Crabtree Matthew J, Hong Candice Sun, Kamranpour Naeimeh, Pitts Sharon, Kabbinavar Fairooz, Patel Cecil, von Euw Erika, Black Alexander, Michelakis Evangelos D, Dubinett Steven M, Slamon Dennis J, Dichloroacetate should be considered with platinum-based chemotherapy in hypoxic tumors rather than as a single agent in advanced non-small cell lung cancer. Journal of cancer research and clinical oncology. 2014; 140(3): 443-52.
Drew Brian G, Hamidi Habib, Zhou Zhenqi, Villanueva Claudio J, Krum Susan A, Calkin Anna C, Parks Brian W, Ribas Vicent, Kalajian Nareg Y, Phun Jennifer, Daraei Pedram, Christofk Heather R, Hewitt Sylvia C, Korach Kenneth S, Tontonoz Peter, Lusis Aldons J, Slamon Dennis J, Hurvitz Sara A, Hevener Andrea L, Estrogen receptor (ER)α-regulated lipocalin 2 expression in adipose tissue links obesity with breast cancer progression. The Journal of biological chemistry. 2015; 290(9): 5566-81.
Wang Jun, Hwang Kiwook, Braas Daniel, Dooraghi Alex, Nathanson David, Campbell Dean O, Gu Yuchao, Sandberg Troy, Mischel Paul, Radu Caius, Chatziioannou Arion F, Phelps Michael E, Christofk Heather, Heath James R, Fast metabolic response to drug intervention through analysis on a miniaturized, highly integrated molecular imaging system. Journal of nuclear medicine : official publication, Society of Nuclear Medicine. 2013; 54(10): 1820-4.
Sullivan William J, Christofk Heather R, The metabolic milieu of metastases. Cell. 2015; 160(3): 363-4.
Fu Xudong, Chin Randall M, Vergnes Laurent, Hwang Heejun, Deng Gang, Xing Yanpeng, Pai Melody Y, Li Sichen, Ta Lisa, Fazlollahi Farbod, Chen Chuo, Prins Robert M, Teitell Michael A, Nathanson David A, Lai Albert, Faull Kym F, Jiang Meisheng, Clarke Steven G, Cloughesy Timothy F, Graeber Thomas G, Braas Daniel, Christofk Heather R, Jung Michael E, Reue Karen, Huang Jing, 2-Hydroxyglutarate Inhibits ATP Synthase and mTOR Signaling. Cell metabolism. 2015; 22(3): 508-15.
Krall Abigail S, Xu Shili, Graeber Thomas G, Braas Daniel, Christofk Heather R, Asparagine promotes cancer cell proliferation through use as an amino acid exchange factor. Nature communications. 2016; 7(1): 11457.
Hong Candice Sun, Graham Nicholas A, Gu Wen, Espindola Camacho Carolina, Mah Vei, Maresh Erin L, Alavi Mohammed, Bagryanova Lora, Krotee Pascal A L, Gardner Brian K, Behbahan Iman Saramipoor, Horvath Steve, Chia David, Mellinghoff Ingo K, Hurvitz Sara A, Dubinett Steven M, Critchlow Susan E, Kurdistani Siavash K, Goodglick Lee, Braas Daniel, Graeber Thomas G, Christofk Heather R, MCT1 Modulates Cancer Cell Pyruvate Export and Growth of Tumors that Co-express MCT1 and MCT4. Cell reports. 2016; 14(7): 1590-601.
Momcilovic Milica, Bailey Sean T, Lee Jason T, Fishbein Michael C, Magyar Clara, Braas Daniel, Graeber Thomas, Jackson Nicholas J, Czernin Johannes, Emberley Ethan, Gross Matthew, Janes Julie, Mackinnon Andy, Pan Alison, Rodriguez Mirna, Works Melissa, Zhang Winter, Parlati Francesco, Demo Susan, Garon Edward, Krysan Kostyantyn, Walser Tonya C, Dubinett Steven M, Sadeghi Saman, Christofk Heather R, Shackelford David B, Targeted Inhibition of EGFR and Glutaminase Induces Metabolic Crisis in EGFR Mutant Lung Cancer. Cell reports. 2017; 18(3): 601-610.
Krall Abigail S, Christofk Heather R, Rethinking glutamine addiction. Nature cell biology. 2015; 17(12): 1515-7.
Gu Wen, Gaeta Xavier, Sahakyan Anna, Chan Alanna B, Hong Candice S, Kim Rachel, Braas Daniel, Plath Kathrin, Lowry William E, Christofk Heather R, Glycolytic Metabolism Plays a Functional Role in Regulating Human Pluripotent Stem Cell State. Cell stem cell. 2016; 19(4): 476-490.
Thai Minh, Thaker Shivani K, Feng Jun, Du Yushen, Hu Hailiang, Ting Wu Ting, Graeber Thomas G, Braas Daniel, Christofk Heather R, MYC-induced reprogramming of glutamine catabolism supports optimal virus replication. Nature communications. 2015; 6(12): 8873.
Flores Aimee, Schell John, Krall Abigail S, Jelinek David, Miranda Matilde, Grigorian Melina, Braas Daniel, White Andrew C, Zhou Jessica L, Graham Nicholas A, Graeber Thomas, Seth Pankaj, Evseenko Denis, Coller Hilary A, Rutter Jared, Christofk Heather R, Lowry William E, Lactate dehydrogenase activity drives hair follicle stem cell activation. Nature cell biology. 2017; 19(9): 1017-1026.
Thaker Shivani K, Ch'ng James, Christofk Heather R, Viral hijacking of cellular metabolism. BMC biology. 2019; 17(1): 59.
Thaker Shivani K, Chapa Travis, Garcia Gustavo, Gong Danyang, Schmid Ernst W, Arumugaswami Vaithilingaraja, Sun Ren, Christofk Heather R, Differential Metabolic Reprogramming by Zika Virus Promotes Cell Death in Human versus Mosquito Cells. Cell metabolism. 2019; 29(5): 1206-1216.e4.
Krall Abigail S, Christofk Heather R, Cell cycle: Division enzyme regulates metabolism. Nature. 2017; 546(7658): 357-358.
Sullivan William J, Mullen Peter J, Schmid Ernst W, Flores Aimee, Momcilovic Milica, Sharpley Mark S, Jelinek David, Whiteley Andrew E, Maxwell Matthew B, Wilde Blake R, Banerjee Utpal, Coller Hilary A, Shackelford David B, Braas Daniel, Ayer Donald E, de Aguiar Vallim Thomas Q, Lowry William E, Christofk Heather R, Extracellular Matrix Remodeling Regulates Glucose Metabolism through TXNIP Destabilization. Cell. 2018; 175(1): 117-132.e21.

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