The proposed project establishes a strong academic-community partnership to broaden and accelerate the translation of bench and clinical science to improve the health of a very diverse population with many disparities in health among different population subgroups. Dr. Johnathan Fielding's background, experience and current senior positions both at UCLA and in the County of Los Angeles, situate him well to provide advice and direction to the bi-directional academic-community partnership. Most of his research, which includes many NIH and foundation grants, has focused on the translation of current best practice as defined by the peer reviewed literature to individual patients and to the population as a whole. His multi-disciplinary background, in pediatrics, public health, preventive medicine, health services research, economic analysis and epidemiology have helped him to establish strong academic-community partnerships, with an emphasis on clinical and community health and related services. He was a founding member of the US Preventive Services Task Force and currently Chair the Community Preventive Services Task Force, an independent expert panel supported by HHS agencies to perform systematic analyses of what population oriented services can be recommended based on explicit criteria for effectiveness (thecommunityguide.org). He also chairs Secretary Sebelius' expert advisory committee on the nation's 2020 Health Objectives. As the appointed Director of Public Health for Los Angeles County (10+million) and County Health Officer, he directs a staff of 4,000 covering a full range of public health services that range from clinical to policy development (see publichealth.lacounty.gov), and cover the full range of ages and health conditions. As a UCLA Professor, he has developed and continues to teach courses in the determinants of health and guest lectures in courses on public health theory and practice. His two major current UCLA based NIH/CDC and foundation funded research projects are improving practical methods to assess the health impact of policy and program decisions and the development of a micro-simulation model to forecast the future health of our population under different set of assumptions that are greatly affected by changes in diagnosis, treatment and prevention. His primary role will be to assure strong bi-directional flow of ideas, information and innovation between the community, including medical practice and public health, and the university, that will receive advice on what research is most likely to make a difference at the community level.