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Peter Bowers, Ph.D. [ Edit Your Profile ]

Work
CTSI Associate Director, Drug Discovery
UCLA Director, Therapeutic Antibody Laboratory

Education:
Degrees:
Ph.D.

About

Dr. Bowers currently oversees biologics discovery as Director of the David Geffen School of Medicine Therapeutic Antibody Laboratory and Associate Director for Drug Discovery in the UCLA CTSI. For the Therapeutic Antibody Platform, he helps guide the process of antibody project selection and therapeutic concept design, and oversees management of all therapeutic project teams. Dr. Bowers also guides all aspects of antibody discovery, engineering and lead candidate selection, including supervision of staff, data management and the screening platform. As part of his entrepreneurial leadership role, Dr. Bowers frequently provides training and education within the CTSI on various topics relating to commercialization of medical technologies.

Prior to this position, he was Senior Director and scientific founder of AnaptysBio, a now publicly traded therapeutic antibody product company [IPO Fall 2015, NASDQ; ANAB] and the leader in the use of somatic hypermutation (SHM) for therapeutic antibody discovery and optimization. There, he oversaw discovery of first-in-class clinical stage antibodies including ANB019, an antibody blocking interleukin-36 receptor for the treatment of the rare inflammatory disease generalized pustular psoriasis (GPP).

Publications
Bowers PM, Boyle WJ, Damoiseaux R, The Use of Somatic Hypermutation for the Affinity Maturation of Therapeutic Antibodies. Antibody Engineering: Methods and Protocols, Third Edition. 2018; .
Robert HorlickDavid KingPeter BowersJennifer DaltonBetty WuTraci RobertsXue ZhangLaurence Altobell, III , (US 9,328,166) Antibodies directed against IL-17 . US9328166B2 - US Grant. 2016; .
David J. KingPeter BowersRobert A. HorlickTamlyn Yee Neben , (US 8,926,978; US 9,951,126) Antibodies directed against nerve growth factor . US8926978B2 - US Grant. 2015; .
Peter M. BowersAndrew B. CubittRobert A. Horlick , (US 9,260,533) Methods of generating libraries and uses thereof . US9260533B2 - US Grant. 2014; .
Audrey MCCONNELLPeter M. BowersDavid J. King , (US 9,133,269) Humanized antibodies directed against complement protein C5 . US9133269B2 - US Grant. 2013; .
McConnell Audrey D, Do Minjee, Neben Tamlyn Y, Spasojevic Vladimir, MacLaren Josh, Chen Andy P, Altobell Laurence, Macomber John L, Berkebile Ashley D, Horlick Robert A, Bowers Peter M, King David J, High affinity humanized antibodies without making hybridomas; immunization paired with mammalian cell display and in vitro somatic hypermutation. PloS one. 2012; 7(11): e49458.
Bowers Peter M, Verdino Petra, Wang Zhengyuan, da Silva Correia Jean, Chhoa Mark, Macondray Griffin, Do Minjee, Neben Tamlyn Y, Horlick Robert A, Stanfield Robyn L, Wilson Ian A, King David J, Nucleotide insertions and deletions complement point mutations to massively expand the diversity created by somatic hypermutation of antibodies. The Journal of biological chemistry. 2014; 289(48): 33557-67.
McConnell Audrey D, Zhang Xue, Macomber John L, Chau Betty, Sheffer Joseph C, Rahmanian Sorena, Hare Eric, Spasojevic Vladimir, Horlick Robert A, King David J, Bowers Peter M, A general approach to antibody thermostabilization. mAbs. 2014; 6(5): 1274-82.
King David J, Bowers Peter M, Kehry Marilyn R, Horlick Robert A, Mammalian cell display and somatic hypermutation in vitro for human antibody discovery. Current drug discovery technologies. 2014; 11(1): 56-64.
Bowers Peter M, Horlick Robert A, Kehry Marilyn R, Neben Tamlyn Y, Tomlinson Geoffery L, Altobell Larry, Zhang Xue, Macomber John L, Krapf Irina P, Wu Betty F, McConnell Audrey D, Chau Betty, Berkebile Ashley D, Hare Eric, Verdino Petra, King David J, Mammalian cell display for the discovery and optimization of antibody therapeutics. Methods (San Diego, Calif.). 2014; 65(1): 44-56.
Horlick Robert A, Macomber John L, Bowers Peter M, Neben Tamlyn Y, Tomlinson Geoffery L, Krapf Irina P, Dalton Jennifer L, Verdino Petra, King David J, Simultaneous surface display and secretion of proteins from mammalian cells facilitate efficient in vitro selection and maturation of antibodies. The Journal of biological chemistry. 2013; 288(27): 19861-9.
Bowers Peter M, Neben Tamlyn Y, Tomlinson Geoffery L, Dalton Jennifer L, Altobell Larry, Zhang Xue, Macomber John L, Wu Betty F, Toobian Rachelle M, McConnell Audrey D, Verdino Petra, Chau Betty, Horlick Robert A, King David J, Humanization of antibodies using heavy chain complementarity-determining region 3 grafting coupled with in vitro somatic hypermutation. The Journal of biological chemistry. 2013; 288(11): 7688-96.
McConnell Audrey D, Spasojevich Vladimir, Macomber John L, Krapf Irina P, Chen Andy, Sheffer Joseph C, Berkebile Ashley, Horlick Robert A, Neben Steven, King David J, Bowers Peter M, An integrated approach to extreme thermostabilization and affinity maturation of an antibody. Protein engineering, design & selection : PEDS. 2013; 26(2): 151-64.
Bowers Peter M, Horlick Robert A, Neben Tamlyn Y, Toobian Rachelle M, Tomlinson Geoffrey L, Dalton Jennifer L, Jones Heather A, Chen Andy, Altobell Laurence, Zhang Xue, Macomber John L, Krapf Irina P, Wu Betty F, McConnell Audrey, Chau Betty, Holland Trevin, Berkebile Ashley D, Neben Steven S, Boyle William J, King David J, Coupling mammalian cell surface display with somatic hypermutation for the discovery and maturation of human antibodies. Proceedings of the National Academy of Sciences of the United States of America. 2011; 108(51): 20455-60.

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