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Ji-Ann Lee, Ph.D. [ Edit Your Profile ]

Work Email Address: jianlee@ucla.edu

Work
CTSI Member, CTSI
UCLA Staff Research Associate, Therapeutic Antibody Laboratory

Education:
Degrees:
Ph.D.

About

Dr. Ji-Ann Lee is Staff Research Associate and molecular biologist in the Therapeutic Antibody Laboratory. Dr. Lee obtained his Ph.D. degree in the laboratory of Dr. Douglas Black in the department of Microbiology, Immunology, and Molecular Genetics at UCLA, where he studied the molecular mechanism of alternative splicing and discovered a novel mechanism for the slow modulation of splicing as cells adapt to external signals. He received postdoctoral training in Dr. Kelsey Martin's laboratory, where he investigated the molecular function of genes associated with autism and demonstrated the importance of RNA metabolism in disease.

Publications
Lin Ming-Yu, Wu Yi-Chien, Lee Ji-Ann, Tung Kuan-Wen, Zhou Jessica, Teitell Michael A, Yeh J Andrew, Chiou Pei Yu, Intracellular Delivery by Shape Anisotropic Magnetic Particle-Induced Cell Membrane Cuts. Journal of laboratory automation. 2016; 21(4): 548-56.
Damianov Andrey, Ying Yi, Lin Chia-Ho, Lee Ji-Ann, Tran Diana, Vashisht Ajay A, Bahrami-Samani Emad, Xing Yi, Martin Kelsey C, Wohlschlegel James A, Black Douglas L, Rbfox Proteins Regulate Splicing as Part of a Large Multiprotein Complex LASR. Cell. 2016; 165(3): 606-19.
Lee Ji-Ann, Damianov Andrey, Lin Chia-Ho, Fontes Mariana, Parikshak Neelroop N, Anderson Erik S, Geschwind Daniel H, Black Douglas L, Martin Kelsey C, Cytoplasmic Rbfox1 Regulates the Expression of Synaptic and Autism-Related Genes. Neuron. 2016; 89(1): 113-28.
Huang Kuo-Wei, Wu Yi-Chien, Lee Ji-Ann, Chiou Pei-Yu, Microfluidic integrated optoelectronic tweezers for single-cell preparation and analysis. Lab on a chip. 2013; 13(18): 3721-7.
Ho Victoria M, Lee Ji-Ann, Martin Kelsey C, The cell biology of synaptic plasticity. Science (New York, N.Y.). 2011; 334(6056): 623-8.
Lee Ji-Ann, Tang Zhen-Zhi, Black Douglas L, An inducible change in Fox-1/A2BP1 splicing modulates the alternative splicing of downstream neuronal target exons. Genes & development. 2009; 23(19): 2284-93.
Lee Ji-Ann, Xing Yi, Nguyen David, Xie Jiuyong, Lee Christopher J, Black Douglas L, Depolarization and CaM kinase IV modulate NMDA receptor splicing through two essential RNA elements. PLoS biology. 2007; 5(2): e40.

Cite the Grant Number Trial Innovation Network Smart IRB