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Gopal Sapparapu, Ph.D., M.B.B.S. [ Edit Your Profile ]

Email Address: GopalSapparapu@ucla.edu

Work
CTSI Member, CTSI
UCLA Platform Technology Manager, Therapeutic Antibody Laboratory

Education:
Degrees:
Ph.D.
M.B.B.S.

About

Dr. Sapparapu joined the Therapeutic Antibody Lab as Platform Technology Manager in July, 2107. In this role, he helps in designing and implementing protocols for high-throughput protein expression and characterization, V domain sequence analysis. kinetics and other relevant areas. His work is focused on developing antibodies for stimulating hematopoiesis and for cancer immunotherapy. Prior to coming to UCLA, he was a Research Assistant Professor at Vanderbilt Vaccine Center at Vanderbilt University. There he helped establish a high-throughput human antibody discovery and characterization platform for identifying lead candidate antibodies against several virus such as Zika, norovirus, chikungunya, dengue and others. He also worked on several antibody engineering projects including designing bispecific antibodies and antibodies for transcytosis and transepithelial migration. His doctoral work involved generation of hybrid proteolytic antibodies against Hepatitis C virus protein E2, HIV gp120, and β amyloid protein.

Publications
Hasan S Saif, Miller Andrew, Sapparapu Gopal, Fernandez Estefania, Klose Thomas, Long Feng, Fokine Andrei, Porta Jason C, Jiang Wen, Diamond Michael S, Crowe James E, Kuhn Richard J, Rossmann Michael G, A human antibody against Zika virus crosslinks the E protein to prevent infection. Nature communications. 2017; 8(7): 14722.
Nivarthi Usha K, Kose Nurgun, Sapparapu Gopal, Widman Douglas, Gallichotte Emily, Pfaff Jennifer M, Doranz Benjamin J, Weiskopf Daniela, Sette Alessandro, Durbin Anna P, Whitehead Steve S, Baric Ralph, Crowe James E, de Silva Aravinda M, Mapping the Human Memory B Cell and Serum Neutralizing Antibody Responses to Dengue Virus Serotype 4 Infection and Vaccination. Journal of virology. 2017; 91(5): 14722.
Sapparapu Gopal, Fernandez Estefania, Kose Nurgun, Bin Cao Nurgun, Fox Julie M, Bombardi Robin G, Zhao Haiyan, Nelson Christopher A, Bryan Aubrey L, Barnes Trevor, Davidson Edgar, Mysorekar Indira U, Fremont Daved H, Doranz Benjamin J, Diamond Michael S, Crowe James E, Neutralizing human antibodies prevent Zika virus replication and fetal disease in mice. Nature. 2016; 540(7633): 443-447.
Gilchuk Iuliia, Gilchuk Pavlo, Sapparapu Gopal, Lampley Rebecca, Singh Vidisha, Kose Nurgun, Blum David L, Hughes Laura J, Satheshkumar Panayampalli S, Townsend Michael B, Kondas Ashley V, Reed Zachary, Weiner Zachary, Olson Victoria A, Hammarlund Erika, Raue Hans-Peter, Slifka Mark K, Slaughter James C, Graham Barney S, Edwards Kathryn M, Eisenberg Roselyn J, Cohen Gary H, Joyce Sebastian, Crowe James E, Cross-Neutralizing and Protective Human Antibody Specificities to Poxvirus Infections. Cell. 2016; 167(3): 684-694.e9.
Shanker Sreejesh, Czakó Rita, Sapparapu Gopal, Alvarado Gabriela, Viskovska Maria, Sankaran Banumathi, Atmar Robert L, Crowe James E, Estes Mary K, Prasad B V Venkataram, Structural basis for norovirus neutralization by an HBGA blocking human IgA antibody. Proceedings of the National Academy of Sciences of the United States of America. 2016; 113(40): E5830-E5837.
Sapparapu Gopal, Czakó Rita, Alvarado Gabriela, Shanker Sreejesh, Prasad B V Venkataram, Atmar Robert L, Estes Mary K, Crowe James E, Frequent Use of the IgA Isotype in Human B Cells Encoding Potent Norovirus-Specific Monoclonal Antibodies That Block HBGA Binding. PLoS pathogens. 2016; 12(6): e1005719.
Flyak Andrew I, Shen Xiaoli, Murin Charles D, Turner Hannah L, David Joshua A, Fusco Marnie L, Lampley Rebecca, Kose Nurgun, Ilinykh Philipp A, Kuzmina Natalia, Branchizio Andre, King Hannah, Brown Leland, Bryan Christopher, Davidson Edgar, Doranz Benjamin J, Slaughter James C, Sapparapu Gopal, Klages Curtis, Ksiazek Thomas G, Saphire Erica Ollmann, Ward Andrew B, Bukreyev Alexander, Crowe James E, Cross-Reactive and Potent Neutralizing Antibody Responses in Human Survivors of Natural Ebolavirus Infection. Cell. 2016; 164(3): 392-405.
Long Feng, Fong Rachel H, Austin Stephen K, Chen Zhenguo, Klose Thomas, Fokine Andrei, Liu Yue, Porta Jason, Sapparapu Gopal, Akahata Wataru, Doranz Benjamin J, Crowe James E, Diamond Michael S, Rossmann Michael G, Cryo-EM structures elucidate neutralizing mechanisms of anti-chikungunya human monoclonal antibodies with therapeutic activity. Proceedings of the National Academy of Sciences of the United States of America. 2015; 112(45): 13898-903.
Smith Scott A, Silva Laurie A, Fox Julie M, Flyak Andrew I, Kose Nurgun, Sapparapu Gopal, Khomandiak Solomiia, Khomadiak Solomiia, Ashbrook Alison W, Kahle Kristen M, Fong Rachel H, Swayne Sherri, Doranz Benjamin J, McGee Charles E, Heise Mark T, Pal Pankaj, Brien James D, Austin S Kyle, Diamond Michael S, Dermody Terence S, Crowe James E, Isolation and Characterization of Broad and Ultrapotent Human Monoclonal Antibodies with Therapeutic Activity against Chikungunya Virus. Cell host & microbe. 2015; 18(1): 86-95.
Flyak Andrew I, Ilinykh Philipp A, Murin Charles D, Garron Tania, Shen Xiaoli, Fusco Marnie L, Hashiguchi Takao, Bornholdt Zachary A, Slaughter James C, Sapparapu Gopal, Klages Curtis, Ksiazek Thomas G, Ward Andrew B, Saphire Erica Ollmann, Bukreyev Alexander, Crowe James E, Mechanism of human antibody-mediated neutralization of Marburg virus. Cell. 2015; 160(5): 893-903.

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